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Antibacterial medicinal composition of cefsulodine sodium for injection

A technology for cefsulodin sodium and injection, which is applied in the directions of antibacterial drugs, active ingredients of heterocyclic compounds, etc., can solve the problems of decreased clinical effect and weak bacteriostatic effect of single-variety drug treatment, and achieves the solution of drug resistance, inhibition of Activity, enhanced antibacterial activity and antibacterial broad-spectrum effect

Inactive Publication Date: 2006-02-15
张舰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cefsulodin is a cephalosporin antibiotic, suitable for the treatment of sepsis, pneumonia, bronchitis, bronchiectasis infection, kidney nephritis, cystitis, prostatitis, peritonitis, trauma and burns caused by Pseudomonas aeruginosa which is sensitive to this product. Secondary infection, and acid-resistant, stable chemical properties, less side effects, with the widespread use of antibiotics, clinical drug-resistant strains are increasing, causing bacteria to become more and more resistant to antibiotics, the clinical treatment of a single variety of drugs Decreased effect
[0003] Sulbactam sodium is an inverse inhibitor of β-lactamase. It has inhibitory effect on β-lactamase, but its antibacterial effect is weak, so it cannot be used alone as an antibacterial drug. It is mainly used in combination with β-lactam antibiotics. All kinds of serious infections and infections with drug-resistant strains

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment one, under the condition of aseptic cleaning, cefsulodin sodium (calculated as cefsulodin sodium) 500g and sulbactam sodium (calculated as sulbactam sodium) 500g are combined, operate by powder injection preparation process, 1000 sticks of cefsulodin sodium antibacterial combination medicine were prepared.

Embodiment 2

[0012] Embodiment two, under aseptic and clean conditions, cefsulodin sodium (calculated as cefsulodin sodium) 1000g and sulbactam sodium (calculated as sulbactam sodium) 500g are mixed, operate by powder injection preparation process, prepare 1,000 sticks of cefsulodin sodium antibacterial combination medicine were obtained.

Embodiment 3

[0013] Embodiment three, under sterile and clean conditions, 3000g of cefsulodin sodium (calculated as cefsulodin sodium) and 500g of sulbactam sodium (calculated as sulbactam sodium) are mixed, and the powder injection preparation process is carried out to prepare 3,000 sticks of cefsulodin sodium antibacterial combination drugs were obtained.

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PUM

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Abstract

Disclosed is an antibacterial medicinal composition of cefsulodine sodium for injection, which comprises cefsulodine sodium and amoxicillin sodium by the weight ratio of 1-32 : 1. The composition can be used for treating various infection caused by sensitive bacteria.

Description

technical field [0001] The invention relates to an antibacterial combination medicine of cefsulodin sodium for injection. Background technique [0002] Cefsulodin is a cephalosporin antibiotic, suitable for the treatment of sepsis, pneumonia, bronchitis, bronchiectasis infection, kidney nephritis, cystitis, prostatitis, peritonitis, trauma and burns caused by Pseudomonas aeruginosa which is sensitive to this product. Secondary infection, and acid-resistant, stable chemical properties, less side effects, with the widespread use of antibiotics, clinical drug-resistant strains are increasing, causing bacteria to become more and more resistant to antibiotics, the clinical treatment of a single variety of drugs The effect drops. [0003] Sulbactam sodium is an inverse inhibitor of β-lactamase. It has inhibitory effect on β-lactamase, but its antibacterial effect is weak, so it cannot be used alone as an antibacterial drug. It is mainly used in combination ...

Claims

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Application Information

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IPC IPC(8): A61K31/545A61P31/04A61K31/43
Inventor 张舰李少华
Owner 张舰
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