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Method for extracting simultaneously general alkaloid and starch from fritillary

A technology of total alkaloids and simultaneous separation, applied in the direction of alkaloids, alkaloids, chemical instruments and methods, etc., to achieve the effect of simple process

Inactive Publication Date: 2006-05-03
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many reports on the separation and extraction of total alkaloids in Fritillaria, there is no technical report on the simultaneous separation and extraction of total alkaloids and starch in Fritillaria

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0007] Weigh 100 g of coarsely powdered Fritillaria (Zhejiang) medicinal material powder, add 8 times the volume of 70% ethanol, and extract by heating and reflux at 85°C for 3 times, each time for 2 hours. The obtained 70% ethanol extract is evaporated and concentrated under reduced pressure (5KPa), and the ethanol is reclaimed to obtain the extract, the extract is dissolved with 2% hydrochloric acid, the sand core funnel is suction filtered, and the acid aqueous solution is successively washed with petroleum ether and ethyl acetate (petroleum ether and The volume ratio of ethyl acetate to the aqueous acid solution is 2:1) and extracted three times respectively, then alkalized with ammonia water to a pH above 9, extracted three times with chloroform of an equal volume of alkalized solution, and recovered chloroform to obtain 0.22 g of total alkaloids. After the 70% ethanol reflux extraction, the remaining residue is further crushed, passed through a 160-mesh sieve, and then th...

example 2

[0009] Weigh 100 g of coarsely powdered Fritillaria sichuanensis (Sichuan) medicinal material, add 10 times the volume of 85% ethanol, and extract by cold soaking at 20° C. for 3 times, each time for 24 hours. The obtained 85% ethanol extract was evaporated and concentrated under reduced pressure (5KPa), the ethanol was reclaimed to obtain the extract, the extract was dissolved with 2% hydrochloric acid, the sand core funnel was suction filtered, the acid aqueous solution was extracted 5 times with petroleum ether and ethyl acetate successively, Then use ammonia water to alkalinize to a pH above 9, extract 6 times with chloroform of an equal volume of alkalization solution, and recover chloroform to obtain 0.12 g of total alkaloids. The remaining residue after 85% ethanol reflux extraction is further crushed, passed through a 160M sieve, and then the obtained fine powder is suspended in 2% NaHSO 3 In the aqueous solution, the suspension was allowed to stand for 48 hours, the u...

example 3

[0011] Weigh 100 g of coarsely powdered Fritillaria (Jilin) ​​medicinal material, add 12 times the volume of 95% ethanol, and use ultrasonic extraction for 3 times for 0.5 h each time. The 95% ethanol extract that obtains is concentrated under reduced pressure (5KPa), reclaims ethanol and obtains medicinal extract, and medicinal extract is dissolved with 2% hydrochloric acid, sand core funnel suction filtration, acid aqueous solution is extracted 6 times with sherwood oil and ethyl acetate successively, then Alkalinize with ammonia water to a pH above 9, extract 6 times with chloroform of an equal volume of alkalization solution, and recover chloroform to obtain 0.09 g of total alkaloids. The remaining residue after 95% ethanol reflux extraction is further pulverized, passed through a 160M sieve, and then the obtained fine powder is suspended in 2% NaHSO 3 In the aqueous solution, the suspension was allowed to stand for 48 hours, the upper layer liquid was poured off, and then...

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Abstract

The invnetion discloses a method to separate and extract synchronously total alkaloid and starch from caladium, which comprises: adding the caladium powder into alcohol, heating to reflux extract, hypersonic extract or quench extract, condensing the obtained material; recycling alcohol to obtain and dissolve the extract in chlorhydric acid; filtering, extracting the acid liquid with petroleum ether and ethyl acetate, alkalizing with ammonia to make the pH value larger than 9; extracting with chloroform till supernatant has no color, recycling chloroform and obtaining total alkaloid; drying and breaking the residual. floating on NaOH or NaHSO3 solution of the fine powder; abandoning the supernatant; using distilled water repeatedly to suspense the deposition; abandoning the supernatant, centrifugalizing the liquid, abandoning supernatant and impurity in bottom of liquid, and obtaining pure product. This invention is simple with high yield.

Description

Technical field: [0001] The invention discloses a method for simultaneously separating and extracting total alkaloids and starch from Fritillaria japonicus, belonging to the technical field of separating and extracting chemical components of traditional Chinese medicine. Background technique: [0002] Fritillaria is the dried bulb of Fritillaria, a medicinal plant of the genus Fritillaria, containing alkaloids, saponins, terpenes, steroids, fatty acids, purines, pyrimidines and other compounds. The content in dried bulbs can reach 8%. These substances have multiple effects such as clearing away heat and moistening the lungs, relieving cough and eliminating phlegm. It is a commonly used traditional Chinese medicine for relieving cough and reducing phlegm. In addition, the dried bulbs of Fritillaria also contain more starch, and the total biomass of the dried Fritillaria bulbs is 40-60%. For traditional Chinese medicine chemists and plant chemists, they are concerned with t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07G5/00C08B30/00
Inventor 高文远王书军陈海霞于璟琳
Owner TIANJIN UNIV
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