Recombinant IL-9 antibodies and uses thereof

An IL-9, antibody technology, applied in the field of IL-9 expression-related conditions, treatment, prevention, control and/or improvement of symptoms related to inflammatory conditions or respiratory infections, can solve problems such as insecurity, allergies, etc.

Inactive Publication Date: 2006-07-26
IMMUNOMEDICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0019] 2.2.2 Allergies
Id. Renal and hematopoietic function must be evaluated before and during treatment in all patients receiving amphotericin B, regardless of whether they are receiving flucytosine

Method used

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  • Recombinant IL-9 antibodies and uses thereof
  • Recombinant IL-9 antibodies and uses thereof
  • Recombinant IL-9 antibodies and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0603] 6.1 Example 1: Preparation of anti-IL-9 antibody 7F3COM-2H2

[0604] The anti-IL-9 humanized monoclonal antibody 7F3com-2H2 was prepared using pMI347 vector. The pMI347 vector encoding expression of 7F3com-2H2 consists of the following four separate genetic elements: a glutamine synthetase selectable marker expression cassette, a 2H2κ light chain cDNA expression cassette, a 2H2γ1 heavy chain minigene expression cassette, and a bacterial origin of replication and antibiotics resistance gene.

[0605] The first element, the glutamine synthetase selectable marker expression cassette, consists of the Simian virus 40 (SV40) early enhancer and promoter and SV40 early splicing and polyadenylation for efficient mRNA cleavage and addition of a polyA tail Hamster glutamine synthetase (GS) cDNA composition under domain control. This element is required for the integration, amplification and stable maintenance of the plasmid in the host cell genome.

[0606] Both the 2H2 heavy a...

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PUM

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Abstract

The present invention provides novel antibodies immunospecifically binding to IL-9 polypeptides and compositions comprising the antibodies. The present invention also provides a method for preventing, treating, controlling and/or improving diseases and disorders related to abnormal expression and/or activity of IL-9 or IL-9 receptor or its subunits, autoimmune diseases, inflammatory diseases, A method for proliferative diseases and infections comprising administering one or more antibodies that immunospecifically bind to IL-9 polypeptide. The present invention also includes methods and compositions for diagnosing, monitoring and prognosing said disorders. The invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to IL-9 polypeptides.

Description

[0001] This application claims priority to US Provisional Application No. 60 / 477,797, filed June 10, 2003, and US Provisional Application No. 60 / 462,259, filed April 11, 2003, both of which are hereby incorporated by reference in their entirety. 1. Field of invention [0002] The present invention provides antibodies that immunospecifically bind to IL-9 polypeptides and compositions comprising the same. The present invention also provides preventive and therapeutic regimens for preventing, treating, controlling and / or improving various diseases or one or more symptoms thereof, said regimen comprising administering alone an antibody that immunospecifically binds to an IL-9 polypeptide or Combined with other therapies. Specifically, the present invention provides methods for preventing, treating, controlling and / or improving symptoms associated with inflammatory disorders (such as asthma) or respiratory tract infections, the method comprising administering to a human subject an ...

Claims

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Application Information

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IPC IPC(8): A61K39/395C07K14/52G01N33/53
Inventor J·L·里德J·达维斯J·D·沃特金斯H·吴Y·唐
Owner IMMUNOMEDICS INC
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