Electronic time-temperature indicator and logger

A technology of temperature indicators and time, applied to record carriers used in machines, thermometers, parts of thermometers, etc., can solve problems such as waste, inappropriate warnings, etc.

Inactive Publication Date: 2006-07-26
斯蒂芬·埃利奥特·兹维格
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0035] The second type is a non-indicating electronic time-temperature monitor and electronic data logger
The second type also monitors time and temperature chemically or electronically, but does not output the data in a manner that is easily accessible to less skilled users without additional equipment
As a result, they have a tendency to trigger either too early or too late, which leads to either waste or inappropriate warnings

Method used

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  • Electronic time-temperature indicator and logger
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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0132] Example 1: Insulin time-temperature monitor:

[0133] In order to properly configure the device, the stability of the material of interest should first be characterized. To this end, a quantitative "maximum acceptable degradation" criterion should be established and used to determine the stability lifetime of the material when it is stored at various temperatures. Then, determine the stability life at various test temperature levels, and use this stability life as input to the stability programming calculations.

[0134] The experimental data are then used to generate a curve or equation that is fitted to the observed data. Use this curve to calculate the stability life at intermediate temperatures.

[0135] As an example, consider a generic injectable drug, insulin. Insulin is often carried by diabetics when traveling, but its performance decreases if exposed to high levels of temperature for too long. The book "The Galenic Medicine of Insulin" by Brange et al. [No...

example 2

[0190] Example 2: Other drug monitoring applications:

[0191] There are a number of medically important antibiotics, such as beta-lactam antibiotics (among them Ceftazidime, Cefepime, Imipenern, Meropenem, Cefpirome antibiotics, or others) which, if ingested by continuous infusion into an ambulatory patient, are is the most effective. Such a continuous infusion of antibiotics is very useful in the treatment of cystic fibrosis, immunocompromised chemotherapy patients who are at risk of sepsis, and many other conditions.

[0192] Current continuous perfusion pump (either mechanical or elastomeric) technology is unsatisfactory due to the poor thermal stability of β-lactam antibiotics. In liquid form, many β-lactam antibiotic drugs deteriorate after only a few hours of exposure to temperatures in excess of 25°C. Since the human body temperature is 37°C, conventional ambulatory perfusion pumps, which are usually worn under clothing, typically expose the drug to unacceptable leve...

example 3

[0199] Example 3: Blood Bank Application: A good example of the relatively complex time-temperature stability curves that can be obtained in the case of blood storage in a blood bank. Currently, storage conditions for whole blood are:

[0200] Table 4: Blood Bank Storage Conditions for Whole Blood

[0201] temperature

time

＜0℃

due soon

1-6℃

up to 42 days

10℃

up to 24 hours

11℃

up to 5 hours

20℃

due soon

[0202] Although the curve through all the data points in Table 4 may not fit the Arrhenius equation, this curve can be approximated by a mixture of different Arrhenius curves plus a mixture of other functions, where each Each curve operates in a different part of the temperature zone.

[0203] Here, as in Example 1, the Arrhenius exponential equation can be used to calculate the values ​​between the experimental data points as described above, also together with an equation similar to Exa...

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Abstract

The invention relates to an improved electronic time-temperature indicator(10) with visual output(4), and a device and a method to monitor the thermal history(2) of the complex material which is in nonconformity with the simple degradation equation based on Arrhenius law and to quickly estimate the goodness of fit of the tracked complex material in after use. In particular, the invention discloses an electronic time-temperature indicating device(1) which is capable of programming repeatedly with high speed based on electronic data transmission technique. The electronic time-temperature indicator is easy to set the thermal time-temperature stability distribution of any material. The electronic time-temperature indicator can be used to produce separate, low-cost universal time-temperature indicators in a large scale, and then programs to simulate the stability characteristic of any material if interested.

Description

technical field [0001] The present invention relates to an improved electronic time-temperature indicator with a visual output, an improved thermal modeling algorithm for monitoring the thermal history of a material and the subsequent suitability for use of the tracked material can be quickly determined by visual or other means other devices and methods. The present invention is also well suited for monitoring the thermal stability of complex materials not well characterized by standard Arrhenius exponential regression curves. [0002] This application is an International Patent Application of US Patent Application 10 / 824709, filed April 14, 2004, entitled "Electronic Time-Temperature Indicator and Recorder", said US Patent Application being filed August 5, 2003 Continuation-in-Part of US Patent Application 10 / 634297. This application claims the benefit of priority to US Provisional Patent Application 60 / 465434, filed April 25, 2003, and US Provisional Patent Application 60 / ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G08B17/00G01K1/00G01K3/04
CPCG01K3/04G06K19/0717
Inventor 斯蒂芬·埃利奥特·兹维格
Owner 斯蒂芬·埃利奥特·兹维格
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