A kind of production method of high-tower organic-inorganic compound fertilizer, comprising slurry mixing, granulation, drying, cooling, screening, active humic acid is added in urine, after fully mixing, the obtained mixed slurry is sent into high Tower granulator granulation. The present invention uses active humic acid as the filling material produced by high-tower compound fertilizer, which can not only solve the problem of low nitrogen utilization rate, but also improve the solubility of the product, and combine the synergistic function of humic acid with fertilizer production, It is possible to develop a multifunctional, synergistic and value-added fertilizer. Using the two-stage mixing granulation technology, the problem of the imbalance of the solid-liquid ratio caused by the large solid ratio in the production of organic and inorganic fertilizer products in the high-tower production line is solved; during the production process, urine and humic acid are mixed in the first-stage mixing tank to cause chelation Combination reaction, change their internal valence bond structure, form a large number of stable complex substances, and also help to improve the sustained release of urea.