The invention belongs to the technical field of the metal plate forming and relates to an integral panel creep aging forming tool based on an autoclave. The tool comprises a support structure, a reference platform, a clamping plate, a limiting base, an internal side wall, an external side wall, a base plate and a sealing structure, wherein the support structure is of a frame structure, the reference platform is fixed on a plane of the support structure, the reference platform is provided with the limiting base, and the internal side wall and the external side wall are arranged around the reference platform. The integral panel creep aging forming tool adopts a detachable clamping mode to bring convenience to target profile adjustment and greatly save time and economic cost. The integral tool is large in size and high in precision, and an integral wall which is 5.5 meter long can be formed. The support structure of the tool adopts a mode of a frame so that not only the integral rigidity requirements can be met, but also the uniformity of a temperature field can be ensured. The side walls around the tool can be disassembled, so that the clamping plate can be conveniently replaced, and the deformation and heat processing problems caused by welding can be reduced. With the adoption of a unique sealing structure of the tool, a sealing bag cannot be damaged under the pressure of 1.5MPa of the autoclave so as to ensure the sealing effect.