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N-amber diacyl chitosan self-assembling nano particles and process for preparing same

A technology of succinic diacyl chitosan and nanoparticles, which is applied in the field of N-succinic diacyl chitosan self-assembled nanoparticles and its preparation, which can solve the problems affecting the release of macromolecular substances and harsh preparation conditions

Inactive Publication Date: 2006-09-27
YANGZHOU UNIV
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Problems solved by technology

The covalent cross-linking method often affects the release of macromolecular substances; the precipitation method is a heterogeneous reaction, and the preparation conditions are harsh

Method used

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  • N-amber diacyl chitosan self-assembling nano particles and process for preparing same
  • N-amber diacyl chitosan self-assembling nano particles and process for preparing same
  • N-amber diacyl chitosan self-assembling nano particles and process for preparing same

Examples

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Embodiment Construction

[0023] Preparation of N-succinoyl chitosan

[0024] Take 1g of chitosan, place it in a three-necked flask, add 200ml, 1% acetic acid aqueous solution, stir to make it dissolve completely, and form a chitosan acetic acid aqueous solution with a concentration of 0.5%; Water acetone to form an acetone solution of succinic anhydride; slowly stir at room temperature, add the acetone solution of succinic anhydride to the above-mentioned chitosan acetic acid aqueous solution dropwise for 1 hour, then raise the temperature to 40°C and control it at 40°C , reacted for 4h under rapid stirring; after the reaction was completed, the product was cooled to room temperature, poured into anhydrous acetone for precipitation, suction filtered, and the product was collected, and the product was washed with 70% acetone, 80% acetone, and anhydrous acetone successively, and then washed at 40 °C and vacuum drying for 24 hours to obtain 1.1 g of N-succinic diacyl chitosan as a white solid.

[0025] ...

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Abstract

The invention discloses a self-assembling nanometer particle and preparing method of N-amber diacylchitosan, which comprises the following steps: putting succinic anhydride acetone solution in the chitosan acetate aqueous solution; heating; stirring; cooling until atmosphere temperature; sedimenting in the anhydride acetone; sucking; washing; drying at 40 deg.c in the vacuum to produce white solid of N-amber diacylchitosan; dispersing in the distiller; stirring at 30 deg.c through magnetic force to produce the self-assembling nanometer particle. The invention solves the problem of large molecule releasing or non-even phase reaction, which overcomes the defect of ill preparing condition.

Description

technical field [0001] The invention relates to N-succinyl chitosan, in particular to N-succinyl chitosan self-assembled nanoparticles and a preparation method. Background technique [0002] Chitosan is a deacetylated derivative of chitin, which can be directly derived from natural polysaccharides in nature, and is the only alkaline polysaccharide. Due to its good biocompatibility and biodegradability, the application of chitosan and its derivatives in the biological and medical fields has attracted much attention. [0003] In the fields of biology and medicine, the preparation methods of chitosan derivative nanoparticles that can be used as bioactive macromolecules and drug carriers mainly include: covalent cross-linking method, precipitation method, self-assembly method, etc. The covalent cross-linking method often affects the release of macromolecular substances; the precipitation method is a heterogeneous reaction, and the preparation conditions are harsh. Contents of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L5/08
Inventor 陈天朱爱萍袁兰花吴昊鲁萍
Owner YANGZHOU UNIV
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