Lacidipine pharmaceutical formulation preparing method

Abstract

The invention relates to a process for preparing pharmaceutical preparation of Lacidipine, wherein the preparation prepared through the method has good dissolving property.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical preparation of lacidipine and a preparation method thereof. The chemical name of lacidipine is 5-[2-[3-(1,1-dimethylethoxy)-3-oxopropenyl]phenyl]-1,4-dihydrodimethyl, 5- Diethyl dipicolinate (E). Background technique [0002] Invention patent CN1242987A discloses a pharmaceutical preparation of ziprasidone, wherein the particle size of ziprasidone free base crystal particles or ziprasidone hydrochloride crystal particles is equal to or less than 85 μm, and the pharmaceutical preparation has better dissolution performance. [0003] Similar to the above-mentioned pharmaceutical preparations of ziprasidone, in order to improve the dissolution rate of lacidipine, the method of ultrafine pulverization is generally adopted, that is, grinding lacidipine (or lacidipine together with a pharmaceutically acceptable carrier), In order to increase its specific surfa...

AI Technical Summary

Problems solved by technology

[0004] However, ultrafine pulverization will increase the specific surface area of ​​the drug, accompanied by a large amount of energy consumption. At the same time, due to the increase in the specific surface area of ​​the drug, the hygroscopicity of the dru