A kind of lacidipine silica gel adsorption solid dispersion and its preparation

A technology of solid dispersion and lacidipine, which is applied in the field of medicine, can solve the problems of complicated operation and the use of a large amount of organic solvents, and achieves the effects of good economy, simple and easy operation and good stability in the preparation process.
CN103784963BInactive Publication Date: 2016-08-31SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2016-08-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a lacidipine silica gel adsorption solid dispersion and a preparation method thereof. The method uses hydrophilic gas phase silica as a carrier and adopts supercritical fluid (SFC) technology to prepare the lacidipine silica gel adsorption solid dispersion. The method effectively increases the water dissolubility of lacidipine and improves the oral bioavailability of lacidipine. The preparation method does not use any organic solvent, overcomes the drug safety problem caused from organic solvent residues, is simple and easy to operate, and has low cost and good economical efficiency.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a lacidipine silica gel adsorption solid dispersion and a preparation method thereof. Background technique

[0002] Lacidipine is a new type of long-acting dihydropyridine calcium channel blocker, its chemical name is (E)-4-[2-[3-(carboxy tert-butyl)-3-oxo-1- Propyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridine-diethyl carboxylate, the structural formula is as follows. Lacidipine is highly selective, acting on smooth muscle calcium channels, mainly expanding peripheral arteries, reducing peripheral resistance, and has a strong and lasting antihypertensive effect. It has no significant effect on the cardiac conduction system and myocardial systolic function. And can improve the diastolic function of the damaged hypertrophic left ventricle, and anti-atherosclerosis. It is relatively safe for elderly patients with coronary heart disease, heart failure, renal insuffic...

Claims

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