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Medicinal composition for use in treating diabetes, and preparation method

A composition and diabetes technology, applied in the treatment of type II diabetes, the composition of sulfonylurea compounds and traditional Chinese medicine and its preparation, can solve the problems of no research reports on compound preparations

Inactive Publication Date: 2006-12-06
北京国丹药物技术开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are research reports on the use of traditional Chinese medicine monomers combined with chemical drugs (report of 50 cases of type 2 diabetes treated with mepidar tablets and berberine, "Journal of Jiangxi Medical College" Sheng Kai et al., Vol.42, No.4, 2002), It has been confirmed that such combination therapy has a positive effect, but there is no research report on such a compound preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of Example 1 Compound Glipizide and Berberine Tablets

[0046] Glipizide 2.5g

[0047] Berberine (Berberine) 300g

[0048] Starch 200g

[0049] Hydroxypropylmethylcellulose (HMPC) 1.5% appropriate amount

[0050] Magnesium Stearate 5.0g

[0051] Glipizide, berberine, starch, and 1.5% HMPC are added in an appropriate amount to make a soft material, granulated with a 16-mesh sieve, ventilated and dried at 60°C, granulated with a 16-mesh sieve, mixed with magnesium stearate, and pressed into tablets. Coated, that is. Each tablet contains 2.5mg of glipizide and 300mg of berberine.

Embodiment 2

[0052] Preparation of Example 2 Compound Glipizide Coptidis Coptidis Tablets

[0053] Glipizide 2.5g

[0054] Coptis 1800.0g

[0055] Starch 200.0g

[0056] Hydroxypropylmethylcellulose (HMPC) 1.5% appropriate amount

[0057] Magnesium Stearate 3.5g

[0058] Take the Chinese medicine Coptidis Rhizome, grind it into powder, heat it in an ethanol hot water bath to reflux for 0.5h, let it dissolve for 1h, and filter it with suction. Ethanol (recovered) until brown-red syrupy. Then add 1% acetic acid and heat to dissolve, filter with suction to remove insoluble matter, then add concentrated hydrochloric acid dropwise to the solution until the solution is cloudy, let it cool down, and the berberine hydrochloride with yellow needles will precipitate, filter with suction, and use for crystallization Wash twice with ice water and once with acetone, then heat the crude product until just dissolved and boil, adjust the pH to 8.5-9.8 with milk of lime. Cool, filter out impurities, ...

Embodiment 3

[0059] The preparation of embodiment 3 compound recipe glipizide berberine capsules

[0060] Glipizide 2.5g

[0061] Berberine (Berberine) 100g

[0062] Starch 200g

[0063] Hydroxypropylmethylcellulose (HMPC) 1.5% appropriate amount

[0064] Magnesium Stearate 3.5g

[0065] Add glipizide, berberine, starch, and 1.5% HMPC in an appropriate amount to make a soft material, granulate with a 16-mesh sieve, ventilate and dry at 60°C, granulate with a 16-mesh sieve, add magnesium stearate, mix well, and divide into capsules. Pack it up and get it. Each capsule contains 2.5mg of glipizide and 100mg of berberine.

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Abstract

A composite medicine for treating diabetes and preventing and treating its complications is proportionally prepared from glipizide and Chinese-medicinal material(s) chosen from balsam pear, coptis root and gynostemma pentaphyllum. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes and a preparation method thereof, in particular to a composition of a sulfonylurea compound and traditional Chinese medicine for treating diabetes and a preparation method thereof. The composition can be used for the treatment of diabetes, especially for the treatment of type II diabetes. Background technique [0002] Diabetes mellitus (DM) is one of the world's public health problems and is a metabolic disease with multiple etiologies. According to the report of WHO in 1997, there are currently 113.5 billion diagnosed DM patients in the world, which is expected to increase to 219.9 billion in 2025. According to the sample survey results of 11 provinces and cities in my country in 1996, the number of patients was 30 million, and the adult prevalence rate reached 3.21%. The prevalence of DM varies greatly among countries. It is estimated that by 2025, the countries with the la...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/424A61K31/4704A61K31/4375A61K9/14A61K9/20A61K9/48A61P3/10A61K31/17A61K31/40
Inventor 王振国贾志丹韩春磊王淑娟
Owner 北京国丹药物技术开发有限公司
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