Nanometer berberine hydrochloride emulsion and its prepn process

A technology of berberine hydrochloride and milk preparations, applied in the field of medicine, can solve the problems of frequent medication times, low bioavailability, and poor tolerance for patients, and achieve simple and feasible formulas and methods, good biocompatibility, and increased dispersibility Effect

Inactive Publication Date: 2007-01-03
NORTHWEST A & F UNIV
View PDF0 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These traditional preparations have low oral bioavailability (generally about 10%) due to the first-pass effect of the liver on the drug and low solubility in water.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nanometer berberine hydrochloride emulsion and its prepn process
  • Nanometer berberine hydrochloride emulsion and its prepn process
  • Nanometer berberine hydrochloride emulsion and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1: Oral soft capsule preparation of berberine hydrochloride nanoemulsion

[0090] 1) Weigh 0.1g of berberine hydrochloride, 5g of n-butanol, 20g of Tween-80, 10g of Span-80, 24g of medicinal IPM, 2g of mannitol, and 38.9g of distilled water.

[0091] 2) Mix the Tween-80 and berberine hydrochloride of the weight, and stir with a constant temperature magnetic stirrer at 200rpm, and let the berberine hydrochloride be partially dissolved at 80°C;

[0092] 3) add the RH-40 and n-butanol of described weight again and let berberine hydrochloride dissolve completely, obtain the solution of orange;

[0093] 4) adding the weight of medicinal IPM, in a constant temperature water bath at 80°C, adding half of the weight in distilled water to dissolve the clear solution;

[0094] 5) add the sweetener of described weight and add the distilled water of half of described weight at last, mix, obtain the berberine hydrochloride nanoemulsion medicine of the present invention; ...

Embodiment 2

[0096] Embodiment 2: berberine hydrochloride nanoemulsion oral liquid preparation

[0097] 1) Weigh 0.2g of berberine hydrochloride, 5g of glycerin, 16g of Tween-80, 8g of Span-80, 6g of medicinal liquid paraffin, 2g of sucrose, and 62.8g of distilled water, and set aside; steps 2), 3), 4), 5) same as embodiment 1;

[0098] 6) Directly put the oral liquid into glass or plastic tubes (prepared by existing methods for preparing glass or plastic tubes).

Embodiment 3

[0099] Embodiment 3 berberine hydrochloride nanoemulsion oral liquid preparation

[0100] 1) Weigh 0.2g of berberine hydrochloride, 5g of absolute ethanol, 16g of Tween-60, 8g of Span-80, 6g of salad oil, 5g of mannitol, and 59.8g of distilled water, and set aside; steps 2), 3), and 4) , 5) and 6) are the same

[0101] Example 2 is the same.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to view more

Abstract

The present invention discloses one kind of nanometer berberine hydrochloride emulsion. The nanometer berberine hydrochloride emulsion consists of berberine hydrochloride 0.1-2 wt%, surfactant 20-40 wt%, co-surfactant 10-20 wt%, solvent 1-10 wt%, oil phase 5-30 wt%, sweetener 1-5 wt% and distilled water 27.5-70 wt%. The nanometer berberine hydrochloride emulsion has raised berberine hydrochloride dissolubility, raised bioavailability, lowered toxic side effect, simple preparation process and low production cost.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of berberine hydrochloride, which is a drug for treating digestive system, cardiovascular system and various tumor diseases, in particular to a berberine hydrochloride nanoemulsion drug and a preparation method thereof. Background technique [0002] Berberine (commonly known as berberine) is a quaternary ammonium isoquinoline alkaloid extracted from the rhizomes of Coptis chinensis and other plants. It has been used as a digestive system disease in my country for more than 3,000 years, and it mainly treats intestinal inflammation. Modern studies have confirmed that berberine can be widely used in various cardiovascular systems, and it also has excellent curative effects on various tumors. Because berberine is insoluble in water, the main preparations in the domestic and foreign markets are various tablets and capsules of berberine. These traditional preparations have low...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/4375A61K47/34A61P1/00A61K47/26A61K47/44
Inventor 欧阳五庆孙红武
Owner NORTHWEST A & F UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap