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Method for extraction and separation of red rooted salvia

A technology of salvia miltiorrhiza and medicinal materials, applied in the field of medicine, can solve problems such as different extraction methods and unsuitable traditional Chinese medicinal materials

Inactive Publication Date: 2007-01-31
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction method of traditional Chinese medicine is the focus of research in the field of traditional Chinese medicine. Researchers have always focused their research on which method can be used to obtain more active ingredients from Chinese medicinal materials. Therefore, the current situation of extraction of Chinese medicinal materials is: for different The extraction methods of the effective components of Chinese herbal medicines are also different, and different extraction methods for different Chinese herbal medicines require a large number of different extraction equipment to support the extraction of Chinese herbal medicines, which is not suitable for the standardization of Chinese herbal medicine extraction

Method used

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  • Method for extraction and separation of red rooted salvia
  • Method for extraction and separation of red rooted salvia
  • Method for extraction and separation of red rooted salvia

Examples

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Embodiment 1

[0098] (1) Extraction process: Weigh 250g of Salvia miltiorrhiza medicinal materials, crush it and sieving, then add ethyl acetate and ethanol, and heat to extract the extract fr.1. Add ethanol to the dregs and heat to extract the extract fr.2. Finally, water is added to the dregs and heated to extract the extract fr.3.

[0099] (2) Separation process: Concentrate the extract fr.1 to obtain 16.8g extract, mix the sample with silica gel, and separate it with a normal phase silica gel column. First, use petroleum ether and ethyl acetate as the mobile phase to obtain the eluent fr.4, then change chloroform and methanol as mobile phases to obtain eluent fr.5, concentrate to obtain 2.3g sample, and finally use methanol as mobile phase to obtain eluent fr.6. Concentrate the extract fr.2 to obtain 133.6g extract, take 20g extract and dissolve the sample with methanol, and separate it with ODS-C18 column. First, use low-concentration methanol as the mobile phase to obtain eluent fr.7 , An...

Embodiment 2

[0120] (1) Extraction process: Weigh 500g of Salvia miltiorrhiza medicinal materials, crush them and sieving, then add 5-12 times the volume of ethyl acetate and ethanol with a volume ratio of 1:1, heat and reflux for 0.5-3 hours, and extract 1-3 Second, the filtrates were combined to obtain the extract fr.1. Add 5 to 12 times the amount of 70% ethanol to the medicine residue, heat to reflux for 0.5 to 3 hours, extract 1 to 3 times, and combine the filtrate to obtain the extract fr.2. Finally, water is added to the dregs, heated to reflux for 0.5 to 3 hours, and extracted 1 to 3 times, and the filtrate is combined to obtain the extract fr.3.

[0121] (2) Separation process: Concentrate the extract fr.1 to obtain 33.6g extract, mix the sample with silica gel, and separate it with a normal phase silica gel column. First, use petroleum ether and ethyl acetate with a volume ratio of 50:1 as As the mobile phase, obtain eluent fr.4, then change the volume ratio of chloroform and methano...

Embodiment 3

[0142] 1. Extraction and separation of Danshen

[0143] (1) Extraction process: Weigh 250g of Salvia miltiorrhiza medicinal materials, crush it and sieving, then add 8 times the volume of ethyl acetate and ethanol with a volume ratio of 1:1, heat and reflux for 1 hour, extract twice, combine the filtrate to obtain extraction Liquid fr.1. Add 8 times the amount of 70% ethanol to the medicine residue, heat to reflux for 1 hour, extract twice, and combine the filtrate to obtain the extract fr.2. Finally, water was added to the dregs, heated to reflux for 1 hour, and extracted twice, and the filtrate was combined to obtain the extract fr.3.

[0144] (2) Separation process: Concentrate the extract fr.1 to obtain 17.2g extract, mix the sample with silica gel, and separate it with a normal phase silica gel column. First, use petroleum ether and ethyl acetate with a volume ratio of 50:1 as Use the mobile phase to obtain eluent fr.4, then change the volume ratio of...

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Abstract

A standardized extracting and separating method for extracting the chemical components from a Chinese-medicinal material to maximal extent and further separating them to obtain the chemical components with different polarities is disclosed. To be specific, the red sage root is divided into several chemical components according to their polarities. Each component contains only several main compounds. Said components can constitute a component library used for medicine screening to find out novel medicines.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to the standardization of extraction and separation of Salvia miltiorrhiza. Background technique [0002] At present, on a global scale, Chinese herbal medicine has a certain market. As people’s awareness of health requirements increases, as well as the aging and sub-healthy state of the population, people are more eager to return to nature and use highly natural medical treatments. Prevent problems that cannot be solved by some chemically synthesized drugs, so the application of natural botanicals goes beyond the background of its original national traditional culture. Seeking natural medicines with low side effects and high quality and low price has become the goal pursued by pharmaceutical companies all over the world. The European Community has made uniform legislation on herbal medicines, and the status of herbal medicines in countries such as Canada...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P1/16A61P25/20A61P15/00A61K125/00
Inventor 程翼宇贺庆王毅王学伟李云飞胡兴江葛志伟
Owner TIANJIN TASLY PHARMA CO LTD