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System and method for transdermal delivery

A technology of transdermal delivery and electrodes, applied in the field of transdermal and intracellular delivery systems, can solve problems such as the inability to increase the symmetry and uniformity of the electric field, and the inability to guide the delivery of substances into cells.

Inactive Publication Date: 2007-01-31
ALZA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

These prior art systems are used to move substances across the patient's skin but do not provide directed delivery of substances into cells nor provide a means of increasing symmetry and uniformity to the electric fields used

Method used

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  • System and method for transdermal delivery
  • System and method for transdermal delivery
  • System and method for transdermal delivery

Examples

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Embodiment 1

[0152] Use shown in Figure 5-7 The electroporation effect of the system of the present invention can be observed with the type of microprojection array elements. The microprojection element comprises an electroporation pulse delivery electrode with a concentric ring of additional microprojection array electrodes surrounding a core microprojection array. Separating the two arrays by a non-conductive ring creates two electroporation electrodes, each providing a number of microprojections at the sites where intracellular uptake is desired. In this example, intracellular DNA uptake increased after microprojection DNA delivery into HGP was accomplished by applying electroporation pulses through the microprojection array electrodes. DNA uptake was monitored by detecting gene expression at the mRNA level, and the performance of the system was compared to conventional, state-of-the-art large needle array electrodes. This example included seven treatment groups, including microproje...

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Abstract

A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.

Description

[0001] Cross References to Related Applications [0002] [001] This application claims priority to US Provisional Application No. 60 / 520,043, filed November 13, 2003. field of invention [0003] [002] The present invention generally relates to transdermal delivery systems and methods. More specifically, the present invention relates to transdermal and intracellular delivery systems that use electrical potentials to facilitate the movement of substances. Background of the invention [0004] [003] The most traditional methods of administration of active agents (or drugs) are oral or injection. Unfortunately, when administered orally, many active agents are either not absorbed or have adverse effects before entering the bloodstream, making them completely ineffective or substantially less effective and thus do not possess the desired activity. On the other hand, injecting the agent directly into the bloodstream while ensuring that the agent is not modified during administrati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30A61MA61M37/00A61N1/32
CPCA61N1/306A61M37/0015A61M2037/0023A61N1/303A61N1/0476A61N1/044A61N1/327A61N1/0424A61M37/00
Inventor S·亚纳哈南G·维德马J·B·菲普斯
Owner ALZA CORP
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