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Application of biphenyl cyclo-octadiene lignans for reducing toxic and side effect of antitumor agent

A technology of biphenyl cyclooctadiene lignan and biphenyl cyclooctadiene is applied in the application field of biphenyl cyclooctadiene lignan in reducing the toxic and side effects of antineoplastic drugs, and can solve the problem of unseen antineoplastic drugs. To achieve good effects, improve heart function, and reduce toxic and side effects

Active Publication Date: 2007-02-28
梦阳药业上海有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Biphenyl cyclooctadiene lignans (biphenyl cyclooctane lignans) are Schisandra chinensis: the dry ripening of Magnoliaceae Schisandra chinensis (Turcz.) Baill. or Magnoliaceae Schisandra sphenanthera Rehd.et Wils. The main ingredient in the fruit, Schisandra chinensis is listed as the top grade in "Shen Nong's Materia Medica". There are no reports of preventing and reducing the side effects of antineoplastic drugs

Method used

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  • Application of biphenyl cyclo-octadiene lignans for reducing toxic and side effect of antitumor agent
  • Application of biphenyl cyclo-octadiene lignans for reducing toxic and side effect of antitumor agent
  • Application of biphenyl cyclo-octadiene lignans for reducing toxic and side effect of antitumor agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Study on the Prevention of Cardiotoxicity Caused by Adriamycin with Schizandrin B (SchB)

[0048] 1 Materials and methods

[0049] 1.1 Experimental materials: doxorubicin hydrochloride for injection, Italian pharmacia company, batch number: 5E2002-D, SchB, China Institute for the Control of Pharmaceutical and Biological Products, batch number: 110765-200407, dissolved in 0.5% poloxamer. CK, CK-MB, LDH, and GOT were detected by a fully automatic biochemical analyzer. Tissue protein extract, Pierce Company, USA. ICR male mice, weighing 25-30 g, were provided by Shanghai Experimental Animal Center.

[0050] 1.2 Test grouping and administration

[0051] The 162 animals were divided into 6 groups by random grouping method:

[0052] 24 rats in the blank control group were given normal saline 20ml / kg / time by intragastric administration on the 1st to 3rd day of the experiment, once a day, and intraperitoneally injected once within 2 hours after the intragastric a...

Embodiment 2

[0072] Example 2: The preventive effect of five biphenyl cyclooctadiene lignans on other toxic and side effects of doxorubicin

[0073] 1 Materials and methods

[0074] 1.1 Experimental materials: doxorubicin hydrochloride for injection, Italian pharmacia company. Five kinds of biphenyl cyclooctadiene lignans, China Institute for the Control of Pharmaceutical and Biological Products, batch number: 110765-200407. Dissolved in 0.5% poloxamer. ICR female mice, weighing 20-25 g, provided by Shanghai Experimental Animal Center, were randomly divided into groups as follows, with 10 mice in each group.

[0075] 1.2 Animal grouping and drug administration methods and routes

[0076] 10 rats in the control group were injected with normal saline intraperitoneally, once every other day, for 7 consecutive times;

[0077] Adriamycin group (Dox group) 10 rats, Adriamycin 2mg / kg, intraperitoneal injection, once every other day, 7 times in a row;

[0078] Doxorubicin + Schizandrin B 1 gro...

Embodiment 3

[0092] Embodiment 3: 6 kinds of biphenyl cyclooctane lignans reduce the cardiotoxicity caused by daunorubicin

[0093]Experimental method: ICR mice were purchased from Shanghai Experimental Animal Center. Schizandrin A, Schizandrin B, Schizandrin C, Schisandrin ester A, Schisandrol A, Schisandrin B were prepared with 0.5% poloxamer to prepare 1 g / ml mother liquor. The animals were divided into 7 groups, 15 in each group, each mouse in group 1 was given 100 μl solvent (0.5% poloxamer), each mouse in group 2 was given 100 μl schisandrin A, each mouse in group 3 was given 100 μl schisandrin B in stomach, 100 μl schisandrin C in each mouse in group 4, 100 μl schisandrin A in group 5, 100 μl schisandrin A in group 6, each mouse in group 7 Rats were gavaged with 100 μl Schisandra Alcohol B; 3 hours later, the mice were injected with daunorubicin (4 mg / kg) into the tail vein; the drug was given once every 7 days, for a total of 10 times. One week after the last dose, the mice were ...

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Abstract

The invention discloses a preparing method of biphenyl cyclo-octadiene lignans and application in the tumour prevention drug, which is characterized by the following: reducing cardiovascular toxicant or liver toxicant or kidney toxicant or marrow inhibition or immune inhibition or alopecia, adopting schizandrin to lessen side-effect of tumour prevention drug effectively.

Description

(1) Technical field [0001] The invention relates to the application of biphenyl cyclooctadiene lignan in the preparation of medicines for preventing and reducing the toxic and side effects of antitumor drugs. (2) Background technology [0002] Tumor is one of the main causes of human death, and tumor chemotherapy is a major means of treating tumors. However, antineoplastic drugs can cause many toxic and side effects. These side effects include cardiovascular toxicity, liver toxicity, nephrotoxicity, myelosuppression, immunosuppression, hair loss and so on. [0003] Biphenyl cyclooctadiene lignans (biphenyl cyclooctane lignans) are Schisandra chinensis: the dry ripening of Magnoliaceae Schisandra chinensis (Turcz.) Baill. or Magnoliaceae Schisandra sphenanthera Rehd.et Wils. The main ingredient in the fruit, Schisandra chinensis is listed as the top grade in "Shen Nong's Materia Medica". There is no report on preventing and reducing the side effects of antineoplastic drugs...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K31/045A61K31/09A61K31/216A61P35/00A61P43/00
Inventor 胡汛
Owner 梦阳药业上海有限公司
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