Methods of modulating cytokine activity, related reagents

A technology for regulating immunity and drug delivery, which is applied in the field of mammalian cytokines and can solve problems such as stimulation
CN1921886AInactive Publication Date: 2007-02-28SCHERING AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SCHERING AG
Publication Date
2007-02-28
Estimated Expiration
Not applicable · inactive patent
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Abstract

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders. Also provided are methods of administering agonists or antagonists of IL-27 and IL-27 receptor.
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Description

[0001] This application claims the benefit of U.S. Provisional Patent Application no. 60 / 545,762, filed February 17, 2004, which is hereby incorporated by reference in its entirety. field of invention

[0001] The present invention generally relates to the use of mammalian cytokines. More specifically, the present invention discloses receptor subunits of the IL-27 receptor. Background of the invention

[0002] The immune system protects individuals against infectious agents such as bacteria, multicellular organisms, and cancer. This system includes several types of lymphoid and myeloid cells, such as monocytes, macrophages, dendritic cells (DCs), eosinophils, T cells, B cells, and neutrophils. These lymphoid and myeloid cells often produce signaling proteins called cytokines. The immune response includes inflammation, the accumulation of immune cells throughout the body or especially locally. In response to infectious or foreign substances, immune cells secrete cytokines,...

Claims

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