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Methods of modulating cytokine activity, related reagents

A technology for regulating immunity and drug delivery, which is applied in the field of mammalian cytokines and can solve problems such as stimulation

Inactive Publication Date: 2007-02-28
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to Trinchieri et al., supra, IL-27 alone does not appear to have a major role in the initial TH1-type response, but, instead, it stimulates early IFNγ production without seriously affecting T cell differentiation to TH1-type

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

Example I. General method

[0097]Standard methods in biochemistry and molecular biology have been published (see, e.g., Maniatis et al. (1982) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY; Sambrook and Russell (2001) Molecular Cloning, 3rd. , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY; Wu (1993) RecombinantDNA, Vol. 217, Academic Press, San Diego, CA). Standard methods are also described in Ausbel et al. (2001) Current Protocols in Molecular Biology, Vols. 1-4, John Wiley and Sons, Inc. New York, NY, which describes cloning in bacterial cells and DNA mutagenesis (Vol. 1) , Cloning in Mammalian Cells and Yeast (Vol.2), Glycosides and Protein Expression (Vol.3), and Bioinformatics (Vol.4).

[0098] A method for protein purification involving immunoprecipitation, chromatography, electrophoresis, centrifugation and crystallization has been published (Coligan et al. (2000) Current Protocols in Protein Science,...

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Abstract

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders. Also provided are methods of administering agonists or antagonists of IL-27 and IL-27 receptor.

Description

[0001] This application claims the benefit of U.S. Provisional Patent Application no. 60 / 545,762, filed February 17, 2004, which is hereby incorporated by reference in its entirety. field of invention [0001] The present invention generally relates to the use of mammalian cytokines. More specifically, the present invention discloses receptor subunits of the IL-27 receptor. Background of the invention [0002] The immune system protects individuals against infectious agents such as bacteria, multicellular organisms, and cancer. This system includes several types of lymphoid and myeloid cells, such as monocytes, macrophages, dendritic cells (DCs), eosinophils, T cells, B cells, and neutrophils. These lymphoid and myeloid cells often produce signaling proteins called cytokines. The immune response includes inflammation, the accumulation of immune cells throughout the body or especially locally. In response to infectious or foreign substances, immune cells secrete cytokines,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/20A61K38/17A61K39/395A61P9/10A61P11/06A61P17/06A61P19/02A61P37/02A61P37/08A61K48/00C07K16/24C07K16/28
CPCA61K39/395C07K16/2866A61K38/20C07K16/244G01N33/00A61K38/1793C07K2317/73C12N15/00A61P1/04A61P11/00A61P11/06A61P11/08A61P17/02A61P17/06A61P19/02A61P29/00A61P35/00A61P35/04A61P37/00A61P37/02A61P37/08A61P43/00A61P9/10
Inventor R·A·凯斯特林T·K·麦克拉那汉S·普夫兰茨
Owner SCHERING AG
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