Oil-in-water type nanometer peonol emulsion oral liquid and its prepn process

Abstract

The oil-in-water type nanometer emulsion oral liquid of peonol consists of surfactant, oil, peonol and distilled water. Its preparation process includes the following steps:weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly to dissolve peonol in the surfactant; adding distilled water slowly at 20-25 deg.c to form clear and flowing O / W type stable nanometer emulsion oral liquid. The nanometer emulsion oral liquid has high dissolubility of peonol, raised bioavailability of peonol, delayed the time for the medicine to be metabolized in the body, reduced supplementary material amount, low production cost and wide medicine market foreground.

Description

Technical field

[0001] The invention belongs to the field of medicine, and relates to a new dosage form of paeonol medicine, in particular to a transparent and stable oil-in-water paeonol nanoemulsion oral liquid and a preparation method thereof. Background technique

[0002] Paeonol (2-hydroxy-4-methoxy-acetophenone) is one of the main active ingredients of Cortex Moutan and Radix Cynanhi Paniculati. It has a wide range of pharmacological activities, including analgesia, Antipyretic, expelling wind, antibacterial and anti-inflammatory, anti-atherosclerosis, inhibiting platelet aggregation, lowering blood pressure, enhancing cellular immune function and anti-oxidation. In recent years, the anti-tumor effects of paeonol in vivo and in vitro have gradually attracted widespread attention. Paeonol is a fat-soluble drug with a peculiar smell, slightly spicy, soluble in ethanol and methanol, insoluble in cold water, slightly soluble in hot water, unstable and easy to sublimate. Only oi...