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Oil-in-water type nanometer peonol emulsion oral liquid and its prepn process

An oral emulsion, oil-in-water technology, applied in the field of medicine, can solve the problems of slow disintegration of paeonol sugar-coated tablets, low dissolution rate and dissolution rate, and influence on the curative effect of paeonol, and improve the sensory quality. , Improve storage stability, good solubilization effect

Inactive Publication Date: 2007-03-21
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral disintegration of paeonol sugar-coated tablets is slow, the dissolution rate and dissolution rate are low, and the bioavailability is low. Children, the elderly, bedridden patients or patients with dysphagia are inconvenient to take and poor compliance, which affects the curative effect of paeonol play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The oil, surfactant, and co-surfactant selected by calculating the HLB value are used to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the best ratio. Accurately weigh 3.0g of Tween-80, Span-801.0g, and 1.0g of liquid paraffin, put them into a beaker, and manually stir them at a room temperature of 20℃ to mix them evenly. Add 0.5g of paeonol directly and stir. Until all is dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. The viscosity of the system is small at the beginning. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal state or water-in-oil type. The nanoemulsion was continuously added dropwise and continuously stirred. When the system suddenly became thinner, the stable yellow transparent oil-in-water paeonol nanoemulsion oral liquid was produced at this time, and its weight was weighed as 10.0g.

Embodiment 2

[0053] The oil, surfactant, and co-surfactant selected by calculating the HLB value are used to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the best ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil and 0.4g of wheat germ oil, put them into a beaker, stir them by hand at room temperature of 24℃ to mix them evenly, add 0.5g of paeonol directly, and stir until all is dissolved , And then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal state or water-in-oil nanoemulsion. Continue to drip and stir constantly. When the system suddenly becomes thinner, the stable colorless and transparent oil-in-water paeonol nanoemulsion oral liquid is produced at this time, and its total weight is 10.1g.

Embodiment 3

[0055] The oil, surfactant, and co-surfactant selected by calculating the HLB value are used to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the best ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil and 0.4g of olive oil, put them into a beaker, and manually stir them at a room temperature of 24°C to mix them evenly. Add 0.1g of paeonol directly and stir until all is dissolved. Then slowly add distilled water to it and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue Add dropwise and keep stirring. When the system suddenly becomes thinner, the stable colorless transparent oil-in-water paeonol nanoemulsion oral liquid is produced at this time, and its total weight is weighed as 10.0g.

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Abstract

The oil-in-water type nanometer emulsion oral liquid of peonol consists of surfactant, oil, peonol and distilled water. Its preparation process includes the following steps:weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly to dissolve peonol in the surfactant; adding distilled water slowly at 20-25 deg.c to form clear and flowing O / W type stable nanometer emulsion oral liquid. The nanometer emulsion oral liquid has high dissolubility of peonol, raised bioavailability of peonol, delayed the time for the medicine to be metabolized in the body, reduced supplementary material amount, low production cost and wide medicine market foreground.

Description

Technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of paeonol medicine, in particular to a transparent and stable oil-in-water paeonol nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Paeonol (2-hydroxy-4-methoxy-acetophenone) is one of the main active ingredients of Cortex Moutan and Radix Cynanhi Paniculati. It has a wide range of pharmacological activities, including analgesia, Antipyretic, expelling wind, antibacterial and anti-inflammatory, anti-atherosclerosis, inhibiting platelet aggregation, lowering blood pressure, enhancing cellular immune function and anti-oxidation. In recent years, the anti-tumor effects of paeonol in vivo and in vitro have gradually attracted widespread attention. Paeonol is a fat-soluble drug with a peculiar smell, slightly spicy, soluble in ethanol and methanol, insoluble in cold water, slightly soluble in hot water, unstable and easy to sublimate. Only oi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/12A61K47/44A61P29/00A61P31/04A61P9/10A61P7/02
Inventor 欧阳五庆吴旭锦
Owner NORTHWEST A & F UNIV
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