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Immediate release pharmaceutical tablets with height greater than width

A tablet and immediate-release technology, applied in the field of immediate-release heterogeneous compressed pharmaceutical tablets, can solve the problems of insufficient supply, negative impact on compliance, and increased complexity of dosing regimens, etc.

Inactive Publication Date: 2007-05-16
ACCU BREAK TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sica, D., Drugs, 2002;62(3): "Rationale for Fixed-Dose Combinations in the Treatment of Hypertension" claims: "Combination therapy has a fairly long tradition dating back to the 1950s" later in the same article , the authors clearly point out the disadvantage of using a fixed-dose approach, which is greatly corrected by the embodiments of the present invention: "The disadvantage of using a fixed-dose combination is the lack of dosing flexibility for each component, although physicians seldom make the most of the Dosing flexibility inherent in free combination use
This adds complexity to the dosing regimen and may have a negative impact on compliance
In addition, fixed-dose combination therapy does not provide sufficient drug volumes to treat conditions such as sore throat or congestive heart failure that often coexist with high blood pressure

Method used

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  • Immediate release pharmaceutical tablets with height greater than width
  • Immediate release pharmaceutical tablets with height greater than width
  • Immediate release pharmaceutical tablets with height greater than width

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0091] Description of preferred manufacturing scheme

[0092] "Taller than wide" tablets are manufactured containing three segments, each having an active top or upper segment and an active lower or bottom segment separated by a substantially inactive middle segment. A Stokes 27-station three-layer rotary tablet press was used. All formulations are directly compressible powder blends. Blending of the amlodipine formulation and the benazepril formulation was performed in a Patterson-Kelly "V" blender. The middle segment contained 194 mg of Nu-Tab(R) and did not require mixing. Tablets were compressed to a hardness of 35 kgf using a 0.131 inch by 0.3222 inch oval concave tablet punch. The bottom segment is loaded into the die first. The tablet weighs 310 mg. The tablets so produced were 8 mm high; the inactive middle segment was 5-6 mm high and 4 mm wide.

[0093] The weight (mg) of particulate matter constituting each fragment is as follows:

[0094] ...

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PUM

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Abstract

An immediate release compressed pharmaceutical tablet that has two or more segments and a top and a bottom and has a height that exceeds the width of the tablet. The height is measured vertically from the top to the bottom of the tablet while it is in the tablet die in which it is fully compressed, after compression has been completed. The width is measured as the greatest horizontal dimension of the tablet at a location halfway between the top and the bottom of the tablet, except that when the horizontal cross-section of the tablet is substantially rectangular, the width is defined by locating the two shorter sides of the perimeter of the horizontal cross-section, and measuring the length of a line that is at right angle to the shorter sides.

Description

technical field [0001] The present invention provides an immediate release heterogeneously compressed pharmaceutical tablet that is taller than wide, said novel shape of the immediate release tablet yields advantages undisclosed in the prior art in terms of precise break of the tablet, whereby the break of the tablet is more easily produced Predictable amounts of active ingredients. Background technique [0002] Tablets in divisible form containing indentations called scores have long been known and widely used. The problems with dividing scored tablets are well known. These problems include loss of active drug and imprecise splitting of the tablet, so that a tablet intended to be divided into two halves often falls short of this ideal. [0003] Many drugs require dosage adjustments, such as warfarin, whose scored tablets are often divided. These dose adjustments by the patient through tablet splitting have been found to be imprecise. As described below, for many years e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/44A61P3/10A61P5/14A61P7/02A61P9/00A61P25/00A61P29/00
Inventor L·所罗门A·S·卡普兰
Owner ACCU BREAK TECH