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Liver function modifier

A technology of improving liver function and agents, applied in the direction of digestive system, organic chemistry, organic active ingredients, etc.

Inactive Publication Date: 2007-06-06
TMS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the role of orniplabin other than plasminogen activation is currently unknown

Method used

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Embodiment Construction

[0020] The present invention will be specifically described below with reference to examples, but the present invention is not limited by the following examples.

[0021] Improvement effect of liver function in chronic hepatitis model mice

[0022] (1) Preparation of chronic hepatitis model mice

[0023] Mice with chronic hepatitis were prepared by a method modified from the method of Vogten et al. (J. Mathys Vogten et al, Int J Colorectal Dis (2004) 19: 387-394).

[0024] About 30 g of ICR mice (6-week-old, male, Sankyo Labo Service) were given free access to solid chow (Labo MR stock) and distilled water, and were pre-bred for 5 days before being used for the experiment. Animals were reared in an animal rearing room with conditions of 22°C±2°C, humidity of 60±5%, and a photoperiod of 12 hours.

[0025] After pre-feeding, carbon tetrachloride (10% corn oil solution (vol / vol)) was administered intraperitoneally three times a week. The dose was 330 μl / kg for the first time, ...

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Abstract

The invention provides a liver function modifier containing orniplabin as effective ingredient.

Description

technical field [0001] The present invention relates to a liver function improving agent containing orniplabin as an active ingredient. Background technique [0002] Orniplabin, which is a triprenylphenol compound derived from the fungus Stachybotrys microspora, is known to have a plasminogen activation-promoting action (Japanese Patent Laid-Open No. 2004-224737). More specifically, orniplabin binds to plasminogen, which is a fibrinolytic factor, changes its conformation, and promotes the conversion of plasminogen to plasmin by plasminogen activator. . In addition, orniplabin also promotes the binding of plasminogen to fibrin. Orniplabin promotes the dissolution of pulmonary embolism in pulmonary embolism model rats in vivo. [0003] However, the role of orniplabin other than plasminogen activation is currently unknown. SUMMARY OF THE INVENTION [0004] An object of the present invention is to provide a novel liver function improving agent. [0005] The inventors of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61P1/16
CPCA61K31/407A61P1/16A61P43/00C07D491/052
Inventor 莲见惠司前田文彦三森国敏
Owner TMS CO LTD