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Liver function modifier

A technology of liver function, improver, applied in digestive system, organic chemistry, organic active ingredients, etc.

Inactive Publication Date: 2010-12-22
TMS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the role of orniplabin other than plasminogen activation is currently unknown

Method used

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Embodiment Construction

[0020] The present invention will be specifically described below using examples, but the present invention is not limited by the following examples.

[0021] Improvement effect of liver function in chronic hepatitis model mice

[0022] (1) Production of chronic hepatitis model mice

[0023] Mice with chronic hepatitis were produced by a method modified from the method of Vogten et al. (J. Mathys Vogten et al, Int J Colorectal Dis (2004) 19: 387-394).

[0024] About 30 g of ICR mice (6-week-old, male, Sankyo Labo Service) were allowed to freely ingest solid feed (Labo MR stock) and distilled water, and were pre-fed for 5 days before being used for the experiment. Animals were reared in an animal breeding room with conditions of 22°C±2°C, humidity 60±5%, and photoperiod cycle of 12 hours.

[0025] After the pre-feeding, carbon tetrachloride (10% corn oil solution (vol / vol)) was intraperitoneally administered 3 times a week. The dosage was 330 μl / kg for the first time, 400 μg...

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Abstract

The invention provides a liver function modifier containing orniplabin as effective ingredient.

Description

technical field [0001] The present invention relates to a liver function improving agent containing orniplabin as an active ingredient. Background technique [0002] It is known that orniplabin, which is a triprenylphenol compound derived from the fungus Stachybotrys microspora, has a plasminogen activation-stimulating action (JP-A-2004-224737). More specifically, orniplabin binds to plasminogen as a fibrinolytic factor, changes its conformation, and promotes conversion of plasminogen to plasmin by promoting plasminogen activator . In addition, orniplabin also promotes the binding of plasminogen to fibrin. Orniplabin promotes the lysis of pulmonary embolism thrombus in rat model of pulmonary embolism in vivo. [0003] However, effects of orniplabin other than plasminogen activation are currently unknown. Contents of the invention [0004] The object of the present invention is to provide a novel agent for improving liver function. [0005] The inventors of the present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/407A61P1/16
CPCA61K31/407A61P1/16A61P43/00C07D491/052
Inventor 莲见惠司前田文彦三森国敏
Owner TMS CO LTD