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Material for artificial liver and preparation method thereof

A liver and artificial technology, applied in the field of artificial liver materials and its preparation, can solve problems such as easy to fall off, compatibility needs to be improved, and poor stability of adsorbents

Pending Publication Date: 2020-10-30
陈艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compatibility between the coating and the scaffold material needs to be improved, and the adsorbent introduced by soaking is not stable and easy to fall off

Method used

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  • Material for artificial liver and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] A material for an artificial liver, characterized in that it comprises the following components in parts by weight: 15 parts of L-vinylglycine modified epoxy terminal hyperbranched poly(amine-ester), methacryloxypropylene 1 part of azasilazine tricyclic, 10 parts of vinyl β-cyclodextrin quaternary ammonium salt, 1 part of bis(vinylsulfone)propanol, 0.2 part of azobisisobutyronitrile, and 0.5 part of heparin.

[0034]The preparation method of described L-vinylglycine modified epoxy terminal hyperbranched poly(amine-ester) comprises the steps of: adding L-vinylglycine and epoxy terminal hyperbranched poly(amine-ester) to Add 1,4-naphthoquinone to dichloromethane, stir and react at 70°C for 6 hours, remove the solvent by rotary evaporation, wash the product with ether for 3 times, and remove ether by rotary evaporation to obtain L-vinylglycine Modified epoxy end group hyperbranched poly(amine-ester); the mass ratio of the L-vinylglycine, epoxy end group hyperbranched poly(...

Embodiment 2

[0040] A material for an artificial liver, characterized in that it comprises the following components in parts by weight: 16 parts of L-vinylglycine modified epoxy terminal hyperbranched poly(amine-ester), methacryloxypropylene 1.5 parts of azasilatricycle, 12 parts of vinyl β-cyclodextrin quaternary ammonium salt, 1.5 parts of bis(vinylsulfone)propanol, 0.3 parts of azobisisoheptanonitrile, and 0.7 parts of citric acid.

[0041] The preparation method of described L-vinylglycine modified epoxy terminal hyperbranched poly(amine-ester) comprises the steps of: adding L-vinylglycine and epoxy terminal hyperbranched poly(amine-ester) to Chlorobenzoquinone was added into chloroform, stirred and reacted at 73°C for 6.5 hours, then the solvent was removed by rotary evaporation, and the product was washed 4 times with ether, and the ether was removed by rotary evaporation to obtain L-vinylglycine modified epoxy Terminal hyperbranched poly(amine-ester); the mass ratio of L-vinylglycin...

Embodiment 3

[0047] A material for an artificial liver, characterized in that it comprises the following components in parts by weight: 18 parts of L-vinylglycine modified epoxy terminal hyperbranched poly(amine-ester), methacryloxypropylene 2 parts of azosilyl tricyclic, 15 parts of vinyl β-cyclodextrin quaternary ammonium salt, 2 parts of bis(vinylsulfonyl)propanol, 0.35 parts of azobisisobutyronitrile, and 1 part of glycyrrhizic acid.

[0048] The preparation method of described L-vinylglycine modified epoxy terminal hyperbranched poly(amine-ester) comprises the steps of: adding L-vinylglycine and epoxy terminal hyperbranched poly(amine-ester) to Acetone, and 1,4-naphthoquinone was added thereto, stirred and reacted at 75°C for 7 hours, then the solvent was removed by rotary evaporation, and the product was washed with ether for 5 times, and the ether was removed by rotary evaporation to obtain L-vinylglycine modified Epoxy end group hyperbranched poly(amine-ester); the mass ratio of th...

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Abstract

The invention discloses a material for an artificial liver. The material is characterized by being prepared from the following components in parts by weight: 15 to 20 parts of L-vinylglycine modifiedepoxy-terminated hyperbranched poly (amine-ester), 1 to 3 parts of methacryloxypropylsilatrane, 10 to 20 parts of vinyl beta-cyclodextrin quaternary ammonium salt, 1 to 3 parts of bis (vinyl sulfuryl)propanol, 0.2 to 0.5 part of an initiator and 0.5 to 1.5 parts of an anticoagulant. The invention further discloses a preparation method of the material for the artificial liver and the artificial liver prepared from the material for the artificial liver. The material for the artificial liver has good biocompatibility and excellent biodegradability and performance stability, can effectively remove toxins in blood, is safe to use and has high clinical practicability.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a material for an artificial liver and a preparation method thereof. Background technique [0002] In recent years, with the acceleration of the pace of life, the increase of pressure from life and work, and the spread of modern people's social methods with the theme of toasting, the number of patients with liver failure has increased year by year, and it is showing a younger trend. As one of the most important organs of the human body, the liver undertakes multiple complex functions such as synthesis, secretion, metabolism, and detoxification. Once liver failure occurs, it will lead to metabolic dysfunction of the human body, and more serious diseases may occur, bringing patients It caused great pain, seriously affected their health and reduced their quality of life. [0003] Liver transplantation is currently the only effective treatment for liver failure, but the sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/54A61L33/10A61L33/08A61L33/12A61L33/04C08F290/06C08F290/10C08F230/08
CPCA61L27/20A61L27/54A61L33/0011A61L33/0076A61L33/04A61L33/08A61L33/128A61L2300/21A61L2300/232A61L2300/252A61L2300/42A61L2430/28C08F290/061C08F290/10C08F230/08C08L51/08C08L51/02
Inventor 陈艳冀丽娟王立新
Owner 陈艳