Method of treating scarring

a scarring and scarring technology, applied in the field of scarring treatment, can solve the problems of many undesirable changes in the cosmetic appearance of the skin, and achieve the effect of improving the skin quality

Inactive Publication Date: 2005-07-28
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0004] It has been found that certain immune response modifier (IRM) compounds can be used to improve skin quality.
[0005] In some aspects, the present invention provides methods of improving skin quality by topically applying to the skin an IRM compound in an amount effective to improve the quality of the skin.
[0009] In still other aspects, the present invention includes methods for reducing the appearance of skin changes associated with aging by topically applying to an area of skin exhibiting skin changes associated with aging an IRM compound in an amount and for a period of time sufficient to reduce the appearance of skin changes associated with aging.

Problems solved by technology

During aging, the collagen structure can change, thus causing changes in the cosmetic appearance of the skin that many find undesirable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Treatment of Rough, Dry, or Scaly Skin

[0057] Volunteer subjects with superficial basal cell carcinoma (BCC) were randomized to either the 5% imiquimod cream formulation (ALDARA, 3M Pharmaceuticals, St. Paul, Minn.) or a placebo cream (Vehicle) in one of two treatment regimens: (1) once daily for seven days per week (7× / week), and (2) once daily for five consecutive days per week and no treatment for the remaining two days (5× / week). Subjects in each group received treatment for six weeks.

[0058] Subjects were instructed to administer a single application of cream (Vehicle or 5% imiquimod, as assigned) to a target tumor just prior to normal sleeping hours according to the dosing regimen to which they were assigned. The subjects were instructed to wash the tumor lesion prior to applying the cream, and then rub the cream into the tumor and into extramarginal skin about 1 cm around the tumor. The subjects were instructed to leave the cream in place for at least eight hours without occl...

example 2

[0065] Subjects having cutaneous leishmaniasis received standard care for leishmaniasis: meglumine antimonate (GLUCANTIME, Aventis Pharma, 20 mg / Kg) for 20 consecutive days. Subjects were randomized to received, in addition to the meglumine antimonate, either 5% imiquimod cream (ALDARA, 3M Pharmaceuticals, St. Paul, Minn.) or a placebo cream. A thin layer of cream was applied to each lesion every other day for 20 days (i.e., ten total applications). Doses of cream were applied by study personnel blinded to group assignments. Cream was applied with a gentle rubbing action over areas of involved but intact skin—i.e., the whole area of nodular lesions and including the periphery of ulcerative lesions (up to 0.5 cm beyond the edge of each lesion).

[0066] Treatment efficacy was evaluated at follow-up visits one, two, three, six, and twelve months after the completion of treatment. Scar quality was not an original outcome of the study and thus, no well-standardized scale for the assessmen...

example 3

Treatment of Wrinkles

[0067] Wrinkles of skin may be due to natural aging and / or sun damage. Most fine wrinkles on the face are due to natural or innate aging, while coarse wrinkles on the face are the consequence of actinic or sun damage. Although the real mechanism of wrinkles formation in the skin is still unknown, it has been shown that visible fine wrinkles are due to diminution in the number and diameter of elastic fibers in the papillary dermis, and also due to atrophy of dermis as well as reduction in subcutaneous adipose tissue. Histopathology and electron microscopy studies indicate that coarse wrinkles are due to excessive deposition of abnormal elastic materials in the upper dermis and thickening of the skin.

[0068] A 5% cream of imiquimod, the imidazoquinoline amine 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, marketed as ALDARA (3M Pharmaceuticals, St. Paul, Minn.), is provided to a randomized segment of volunteer subjects having facial wrinkles lateral and in...

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Abstract

Methods of treating scarring are disclosed. Generally, the methods include topically administering an IRM compound to the site of a surgical wound for a period of time and in an amount effective for preventing, reversing, or reducing the formation of a scar. Suitable IRM compound compounds include agonists of one or more TLRs.

Description

CROSS-REFERENCE TO RELATED APPLICATION [0001] This application is a continuation of U.S. patent application Ser. No. 10 / 799,999, filed Mar. 12, 2004, which claims priority to U.S. Provisional Patent Application No. 60 / 454,245, filed Mar. 13, 2003.BACKGROUND OF THE INVENTION [0002] Skin condition is continuously affected by various factors including, for example, humidity, UV-light, cosmetics, aging, diseases, stress, cigarette smoking, and eating habits, each of which can result in various skin changes. Additionally, certain changes appear on the skin that are characteristic of aging, many of which are reflected, in particular, by a change in the skin's structure. The main clinical signs of aging of the skin are, in particular, the appearance of fine lines and deep wrinkles, each of which can increase with age. Wrinkles can be caused by both the chronological aging of the skin and photoaging of skin due to exposure of the skin to sunlight, UV-radiation and other forms of actinic rad...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/397A61K31/4745
CPCA61K8/4946A61K31/397A61K31/4745Y10S514/878A61Q19/08Y10S514/844A61K2800/70A61P17/00A61P17/02A61P17/12A61P17/16A61P35/00A61P37/02A61P43/00A61K8/49A61Q19/00
Inventor MILLER, RICHARD L.LEE, JAMES H.OWENS, MARY L.
Owner 3M INNOVATIVE PROPERTIES CO
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