Bicyclic [3.1.0.] heteroaryl amides as type 1 glycine transport inhibitors

a heteroaryl amide and bicyclic technology, applied in the field of bicyclic3 . 1 . 0heteroaryl amides, can solve the problems of ignoring the negative and cognitive aspects of cns, one of the most costly of all diseases, and the cost of cns diseas
US20060229455A1Inactive Publication Date: 2006-10-12PFIZER INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
PFIZER INC
Publication Date
2006-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
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Description

CROSS REFERENCE TO RELATED APPLICATION

[0001] The present application claims benefit of U.S. Ser. No. 60 / 669,472 filed on Apr. 8, 2005 which is incorporated by reference herein in its entirety.BACKGROUND

[0002] The present invention relates to bicyclic[3.1.0]heteroaryl amides and to pharmaceutical compositions containing them and to their use in the treatment of central nervous system disorders, cognitive disorders, schizophrenia, dementia and other disorders in mammals, including humans. These compounds exhibit activity as inhibitors of the glycine type-1 transporter.

[0003] Schizophrenia, a progressive neurological disease, is manifested in its early stages as thought disorders such as hallucinations, paranoid delusions, and bizarre thought patterns, collectively known as positive symptoms. These easily recognizable symptoms gave the disease the historical name “madness”. As the disease progresses, negative symptoms, such as social withdrawal and anhedonia, and cognitive symptoms ...

Claims

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