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Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof

Inactive Publication Date: 2007-02-22
GLOBALFOUNDRIES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008] In a first aspect of the invention, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from a plurality of the non-coding sequences. The at least one conserved region is linked with one or more of the gene coding sequences of the genome. The at least one conserved region is associated with one or more biological processes of the organism.
[0009] In a second aspect of the invention, a method of designing one or more sequences of small interfering RNAs that can interact with one or more sites in a given transcript of a given sequence in a given organism and result in the down-regulation of the expression of the protein product encoded by the given transcript comprises the following steps. One or regions of interest are identified in the sequence of a given transcript. One or

Problems solved by technology

Even though recent work suggested participation of the intergenic and intronic regions in a regulatory role, for the most part, their true function re

Method used

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  • Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof
  • Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof
  • Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof

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Embodiment Construction

[0035]FIG. 1 is a diagram illustrating exemplary methodology 100 for determining associations between non-coding and gene coding sequences in a genome of an organism. In step 102, non-coding sequences from the genome of an organism are obtained. Preferably, the non-coding sequences comprise intergenic and / or intronic sequences. As used herein, the term “intergenic” refers generally to any portion of a deoxyribonucleic acid (DNA) strand that is between gene sequences. Further, as used herein, the term “intronic” refers to any portion of a DNA strand that is encompassed by an intron.

[0036] According to one exemplary embodiment, the genome comprises the human genome. Further, as will be described below, the starting point of the present techniques may be the genome of a single organism, e.g., the human genome.

[0037] In step 104, conserved regions in the intergenic / intronic sequences are identified. As will be described in detail below, these conserved regions may be identified by use...

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Abstract

Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] The present application claims priority to U.S. provisional applications identified as: Ser. No. 60 / 658,251 (attorney docket no. YOR920050130US1), filed Mar. 3, 2005, and entitled “Overrepresentation of Nucleotides in Human Chromosomes and in the 3′ Untranslated Regions of Human Genes;” and Ser. No. 60 / 696,213 (attorney docket no. YOR920050350US1), filed Jul. 1, 2005, and entitled “Techniques For Linking Non-Coding And Gene-Coding Deoxyribonucleic Acid Sequences,” the disclosures of which are incorporated by reference herein.FIELD OF THE INVENTION [0002] The present invention relates to genes and, more particularly, to techniques for linking regions of a genome. BACKGROUND OF THE INVENTION [0003] It is known that the intergenic and intronic regions comprise most of the genomic sequence of higher organisms. The intergenic and intronic regions are collectively referred to as the “non-coding region” of an organism's genome, as opposed to t...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G06F19/00G16B20/30G16B20/20G16B30/00
CPCG16B30/00G16B20/00G16B20/30G16B20/20
Inventor RIGOUTSOS, ISIDOREHUYNH, TIENTSIRIGOS, ARISTOTELISMCHARDY, ALICE CAROLYNMIRANDA, KEVIN CHARLES
Owner GLOBALFOUNDRIES INC