Metabolic uncoupling therapy

a technology of high-energy electrons and uncoupling therapy, applied in the field of high-energy electron-based metabolism, can solve the problems of affecting the effect of metabolizing, affecting the effect of metabolism, so as to maximize the synergy of the agent, minimize undesired side effects, and maximize the desired beneficial effects

Inactive Publication Date: 2007-07-12
MCCLEARY EDWARD LARRY
View PDF6 Cites 27 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018] Further, a method preferably includes selection of MUT agents based on their interactions with each other to maximize synergy of the agents. In another aspect, a method includes combining specific amounts and ratios of a plurality of agents in a MUT formulation for administration in a prescribed manner for a prescribed period of time. Embodiments in accordance with the invention comprise compositions of chemical compounds, MUT age

Problems solved by technology

There is currently an epidemic of lifestyle related health disorders.
Our “stone age” genes are a poor match for the demands placed upon them by our current lifestyles.
A perturbation in a metabolic pathway that produces changes exceeding the normal ranges developed through evolution forces may ultimately derail the delicate chemical balance that forms the basis for c

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0064] An exemplary embodiment in accordance with the invention suitable for metabolic uncoupling therapy of hepatic steatosis / steatohepatitis was formulated. Daily administration of a composition containing the following ingredients is recommended for a period of time necessary to achieve a desired result, typically for a time period in a range of from two months to twelve months, or until resolution of the hepatic fat accumulation and / or inflammation. Two doses to three doses per day are used. One composite daily dose contains:

Coenzyme Q10100mgR alpha lipoic acid300mgEicosapentanoic acid (EPA)1gTrimethylglycine500mgPhosphatidyl choline3gS-adenosyl methionine (SAMe)200mgCarnitine500mgAspartic acid2gVitamin B125mgVitamin B225mgVitamin B325mgVitamin B525mgVitamin B625mgFolic acid800mcg

[0065] A dose may also include:

Biotin1 mgHydroxycitric acid500 mg Vitamin B121 mg

[0066] The clinical condition hepatic steatosis / steatohepatitis, as well as the primary and secondary chemical action...

example 2

[0069] Another exemplary embodiment in accordance with the invention suitable for metabolic uncoupling therapy of hepatic steatosis / steatohepatitis was formulated. Daily administration of a composition containing the following ingredients is recommended for a period of time necessary to achieve a desired result, typically for two months to twelve months, or until resolution of hepatic fat accumulation and / or inflammation. Two doses to three doses per day are used. As discussed above, certain MUT agents provide synergistic secondary benefits when chosen and combined in specific amounts and ratios designed for indicated uses. Pyruvate and EPA have secondary actions as outlined above. Green tea leaf extract lowers the respiratory quotient (RQ) by beneficially modulating the amount of fat the body burns. It increases fat burning and decreases the content of intracellular fat. It also has anti-inflammatory activity. Pyruvate, in addition to oxidizing NADH to decrease the NADH / NAD+ ratio,...

example 3

[0071] An exemplary embodiment in accordance with the invention was formulated for achieving weight loss using metabolic uncoupling therapy (MUT). Two doses to three doses per day are recommended. Additional beneficial attributes are included in this formulation. Fat burning is augmented by utilizing properties in addition to the MUT properties of the agents chosen for this formulation. These include the fact that aspartate increases hepatic fat oxidation utilizing mechanisms described above. Carnitine increases carnitine palmitoyl transferase (CPT) activity. Choline acts to increase carnitine levels. This acts synergistically to increase fat burning. Each dose contains:

Aspartic acid2gBiotin600mgHCA500mgChromium400mcgCarnitine25mgCholine500mgTMG200mgSAMe200mgALA200mgB125mgB225mgFolate1mgNiacinamide275mgCreatine1g

[0072] Each dose may include medium chain triglycerides (MCT).

MCT10 g

[0073] These augment the activation of futile, thermogenic carbohydrate cycles, further adding to th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Massaaaaaaaaaa
Massaaaaaaaaaa
Massaaaaaaaaaa
Login to view more

Abstract

A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

Description

CROSS-REFERENCE TO RELATED APPLICAIONS [0001] This Application is a divisional of U.S. patent application Ser. No. 10 / 462,958 filed on Jun. 17, 2003, which is a continuation-in-part under 37 CFR 1.53(b) of U.S. patent application Ser. No. 09 / 749,584 filed on Dec. 28, 2000, now U.S. Pat. No. 6,579,866, which issued Jun. 17, 2003.FIELD OF THE INVENTION [0002] This invention relates in general to novel concepts involving the metabolism of high-energy electrons in animals, and more particularly to their physiological effects in mammals. BACKGROUND OF THE INVENTION [0003] There is currently an epidemic of lifestyle related health disorders. These include, but are not limited to, high blood pressure, diabetes, dyslipidemia, hyperlipidemia, hypercholesterolemia, insulin resistance, inflammation, vascular disease, heart disease, stroke, overweight, obesity, neuronal and / or cognitive dysfunction, dementia, attention and attention / hyperactivity disorders, mood disorders, muscular damage, musc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K38/43A61K38/38A61K31/714A61K31/7076A61K31/4188A61K31/455A61K31/4415A61K31/122A61K31/191A61K31/201A61K31/202A61K31/205A61K31/385A61K33/06A61K33/24A61K36/328A61K36/82A61K45/06
CPCA61K31/122A61K31/191A61K45/06A61K38/38A61K36/82A61K31/201A61K31/202A61K31/205A61K31/385A61K31/4188A61K31/4415A61K31/455A61K31/7076A61K31/714A61K33/06A61K33/24A61K36/328A61K2300/00A61P17/00
Inventor MCCLEARY, EDWARD LARRY
Owner MCCLEARY EDWARD LARRY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap