Helicobacter pylori proteins useful for vaccines and diagnostics

a technology of helicobacter pylori and proteins, applied in the field of helicobacter pylori proteins, can solve the problems of unfavorable commercial vaccines for i>h. pylori/i>infection or treatment, the correlation with disease state is not yet well established, etc., and achieves no toxicity, no functional contribution, and reduced toxicity

Inactive Publication Date: 2007-10-18
COVACCI ANTONELLO +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Given the heterogeneity found in such assays, correlation with disease state is not yet well established.
At present, there is no commercial vaccine for H. pylori infection or treatment.

Method used

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  • Helicobacter pylori proteins useful for vaccines and diagnostics
  • Helicobacter pylori proteins useful for vaccines and diagnostics
  • Helicobacter pylori proteins useful for vaccines and diagnostics

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Embodiment Construction

A. General Methodology

[0016] The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, recombinant DNA, and immunology, which are within the skill of the art. Such techniques are explained fully in the literature. See e.g., Sambrook, et al., MOLECULAR CLONING; A LABORATORY MANUAL, SECOND EDITION (1989); DNA CLONING, VOLUMES I AND II (D. N Glover ed. 1985); OLIGONUCLEOTIDE SYNTHESIS (M. J. Gait ed, 1984); NUCLEIC ACID HYBRIDIZATION (B. D. Hames & S. J. Higgins eds. 1984); TRANSCRIPTION AND TRANSLATION (B. D. Hames & S. J. Higgins eds. 1984); ANIMAL CELL CULTURE (R. I. Freshney ed. 1986); IMMOBILIZED CELLS AND ENZYMES (IRL Press, 1986); B. Perbal, A PRACTICAL GUIDE TO MOLECULAR CLONING (1984); the series, METHODS IN ENZYMOLOGY (Academic Press, Inc.); GENE TRANSFER VECTORS FOR MAMMALIAN CELLS (J. H. Miller and M. P. Calos eds. 1987, Cold Spring Harbor Laboratory), Methods in Enzymology Vol. 154 and Vol. 15...

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Abstract

This invention provides polypeptides of Helicobacter Pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for preparation. The invention also provides methods of treatment of Helicobacter pylori infection using these vaccines.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 09 / 360,685, filed Jul. 26, 1999 which is a divisional of U.S. application Ser. No. 08 / 471,491, filed Jun. 6, 1995, now U.S. Pat. No. 6,090,611, which is a divisional of U.S. application Ser. No. 08 / 256,848, filed Oct. 21, 1994, now abandoned, which is a U.S. national phase application of PCT / EP93 / 00472, filed Mar. 2, 1993 and PCT / EP93 / 00158, filed Jan. 25, 1993, which two PCT applications claimed priority benefit of Italian application Serial No. FI 92 A 000052, filed Mar. 2, 1992, the entire contents of each application is incorporated by reference herein.BACKGROUND OF THE INVENTION 1. Field of the Disclosure [0002] The present invention relates generally to certain Helicobacter pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. [0003]Helicobacter pylori is a curved, microaerophilic, gram ne...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/02C07H21/00C07K1/00G01N33/53A61K39/00C07H21/04C07K14/195C12N15/74
CPCA61K39/00A61K39/105Y10S530/825C07K14/205C07K14/195
Inventor COVACCI, ANTONELLOBUGNOLI, MASSIMOTELFORD, JOHNRAPPUOLI, RINOMACCHIA, GIOVANNI
Owner COVACCI ANTONELLO
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