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Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection

a technology of adenosine receptor and liver, which is applied in the direction of drug composition, biocide, heterocyclic compound active ingredients, etc., can solve the problems of unknown mechanisms underlying the accelerated outgrowth of inflammation-associated late-stage metastatic tumors

Inactive Publication Date: 2008-10-23
ADENOSINE THERAPEUTICS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005]The present invention provides a novel method for treating recurrent tumor metastases following liver resection comprising administering to

Problems solved by technology

Unfortunately, the mechanisms underlying the accelerated outgrowth of inflammation-associated late-stage metastatic tumors are unknown.

Method used

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  • Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection
  • Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection
  • Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection

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examples

[0282]A mouse model has been enabled in which selective temporary occlusion of blood flow into the left liver lobe results in a profound acceleration of tumor growth in the clamped liver lobes, but not in the unclamped liver lobes. An A2A receptor agonist was then studied to determine its effect on the accelerated tumor growth.

[0283]Detailed Protocol

1. Before the Experiment: Animals

[0284]Male Balb / C mice (10-12 weeks) are housed under standard laboratory conditions with free access to water and chow and a 12-hour dark-light cycle.

2. Before the Experiment: Cell Culture

[0285]The murine colon carcinoma cell line C26 is cultured in Dulbecco's modified Eagle's medium supplemented with 5% heat-inactivated fetal calf serum, penicillin (100 units / ml) and streptomycin (100 μg / ml) in a 5% carbon dioxide environment.

3. Day 0: Induction of Liver Metastases

[0286]Confluent cultures of the C26 cell line are harvested by brief trypsinization (0.05 trypsin in 0.02% EDTA).[0287]After centrifugation, ...

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Abstract

The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A2A adenosine receptors (ARs).

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the priority benefits of U.S. Provisional Application No. 60 / 925,736, filed Apr. 23, 2007, which is expressly incorporated fully herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A2A adenosine receptors (ARs).BACKGROUND OF THE INVENTION[0003]In the United States, approximately 150,000 patients are diagnosed with colorectal cancer each year. About 20% of these patients have metastatic deposits of colorectal cancer in the liver only at the time of diagnosis or develop such metastases during the course of their illness. In the absence of treatment, the prognosis for patients with hepatic colorectal metastases is dismal, with 5-year survival rates of 3% or less. There is now evidence that resection of such metastases can improve the prognos...

Claims

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Application Information

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IPC IPC(8): A61K31/52A61P35/04
CPCC07H19/16A61K31/52A61P35/00A61P35/04
Inventor KRANENBURG, ONNOVAN DER BILT, JARMILABOREL RINKES, INNERIEGER, JAYSON M.
Owner ADENOSINE THERAPEUTICS
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