44 results about "Liver resections" patented technology

Aspects of the present disclosure include a surgical device comprising electrodes on the sides of an end of an effector to aide in sealing during various surgical procedures, such as a liver resection. During a sealing procedure, the surgeon may wipe the surgical site with the end effector, causing the electrodes to touch the fractured area. Electrosurgical energy may be applied to the electrodes during the wiping, causing coagulation of smaller vessels, such as tiny blood vessels and bile ducts in the parenchyma of the liver. In some cases, due to the nature of some smaller vessels, electrosurgical energy should be delicately applied to cause sealing but to avoid overly damaging the remaining tissue. In some embodiments, the thin design of the electrodes allows for an appropriate amount of electrosurgical energy to be applied to the fractured area.

The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A2A adenosine receptors (ARs).

Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.

The invention discloses a method for separating primary adult hepatocytes. The method comprises the following steps: (1) carrying out multi-point puncture on surface of isolated adult hepatic tissue through a needle syringe, and injecting a preperfusate, wherein connective tissues are removed from the isolated adult hepatic tissue; (2) carrying out the multi-point puncture on the surface of the isolated adult hepatic tissue through the needle syringe again, and injecting a IV collagenase solution; (3) separating the isolated adult hepatic tissue, followed by adding the IV collagenase solution and carrying out digesting through vibration at a temperature of 37 DEG C to obtain digest; (4) carrying out filtering for the digest, followed by centrifuging and collecting cell aggregate in the underlayer, then resuspending the adult hepatocyte aggregate through a hepatocyte wash buffer, followed by filtering and centrifuging, then abandoning supernatant and collecting the adult hepatocyte aggregate in the underlayer; (5) washing the adult hepatocyte aggregate in the underlayer from the step (4) through a serum-free DMEM medium to obtain the primary adult hepatocytes. The invention further discloses a disposable special sterile apparatus box for separating the primary adult hepatocytes. With the present invention, the disposable special sterile apparatus box is adopted, the primary adult hepatocytes are separated through the multi-point puncture on the surface of the tissue and the injection, such that operation is simplified, cost is reduced, and the method and the apparatus box are applicable for extracting the hepatocytes from small pieces of the irregular isolated adult hepatic tissues of recovery of liver resection.

Herein disclosed are dual-mode electrosurgical devices designed to function in a first mode in which high-density RF energy is used to cut or vaporize tissue, and then a second mode in which lower-density RF energy desiccates tissue to produce hemostasis, as well as methods of performing electrosurgery using same. Devices formed in accordance with the principles of this invention may be used for any surgical procedure in which highly vascular tissue is cut electrosurgically in a dry or semi-dry field, examples of which include tonsillectomy, liver resection, and cosmetic procedures such as breast augmentation, breast reduction, breast mastopexy, and abdominoplasty.

The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A2A adenosine receptors (ARs).

A laparoscopic liver resection device is described. The device combines the Radiofrequency Ablation (RFA) technology with a cutting mechanism, a blood- flow sensor and a flexible actuation mechanism to simultaneously coagulate and cut the liver tissue and detect the presence of blood flow to confirm avascularity. The present invention eliminates the risk of excess bleeding due to cutting too deep and reduces recovery time and the time spent on re-coagulation of coagulated areas, thereby shortening duration of surgery. Also embodiments prevent excess ablation by stopping ablation activity on the target tissue as soon as insufficient or no blood flow in the target tissue is detected. Thus a closed loop control for a bloodless tissue / organ division method is provided.

The present invention discloses a completely laparoscopic staged hepatectomy using round-the-liver ligation, which is carried out as follows: (1) a complete laparoscopic operation is performed with general anesthesia using round-the-liver ligation, the branches of the portal vein of the hemiliver to be removed are ligated, meanwhile a tourniquet is used to tighten the connecting part between the right and the left hemilivers to block the communicating blood flow between the hemiliver to be removed and the hemiliver to be reserved, a drainage tube is put into the peritoneal cavity at the hepatic hilus, then close the peritoneal cavity, and the operation is completed; (2) the patient gradually resumes eating after the first operation, and recuperate for 6-15 days to make the volume of the hemiliver to be reserved increase to the expected volume of the future liver remnant, in which the expected volume of the future liver remnant should be at least 30-40% of the standard liver volume; (3) after the volume of the hemiliver to be reserved has increased to the expected volume of the future liver remnant, a complete laparoscopic liver resection is carried out with general anesthesia to remove the diseased hemiliver, and then the patient is nursed to be completely recovered.

The invention discloses a novel suction device of a forceps clip for liver resection. The novel suction device comprises a No. 2 forceps clip arm and a suction machine, wherein a No. 2 toothed forcepsclip pad is fixedly mounted on the outer surface of one side, close to the upper end, of the No. 2 forceps clip arm; a No. 1 forceps clip ring is fixedly mounted on the outer surface of the lower endof the No. 2 forceps clip arm; a No. 1 forceps clip arm is arranged at one side of the No. 2 forceps clip arm; a No. 1 toothed forceps clip pad is fixedly mounted on the outer surface of one side, close to the upper end, the No. 1 forceps clip arm; a No. 2 forceps clip ring is fixedly mounted on the outer surface of the lower end of the No. 1 forceps clip arm; a movable pin is arranged at a position between the No. 1 forceps clip arm and the No. 2 forceps clip arm. According to the novel suction device of the forceps clip for the liver resection, disclosed by the invention, the suction machine, a universal suction tube and a tube reeling wheel are arranged and tissues under the forceps clip can be sucked out while a liver is clipped by the forceps clip; the suction tube can be put into anappointed position and the length of the suction tube can be adjusted according to utilization requirements; a better application prospect is brought.

The invention relates to an indocyanine green fluorescence combined multimodal image-guided liver portal vein watershed developing method, and belongs to the technical field of medical images. According to the method, artificial intelligence technologies such as virtual reality, augmented reality and the like are integrated with traditional intraoperative ultrasound and indocyanine green fluorescent staining technologies, so that a surgeon can visualize three-dimensionally complex liver anatomical structures, accurately locate tumors in an operation, plan an operation scheme, accurately achieve developing of a target portal vein watershed, monitor and correct a liver parenchyma disconnection plane in real time, and perform accurate anatomical liver resection. In a liver operation, the method can display a portal vein branch blood flow supply area for supplying tumors in real time, accurately guide a liver resection range, can not only remove micrometastatic tumors that may exist in theportal vein, but also can ensure blood supply of the remaining liver, improve accuracy and safety of the operation, reduce operative complications, and improve efficacy of tumor operation.

Herein disclosed are dual-mode electrosurgical devices designed to function in a first mode in which high-density RF energy is used to cut or vaporize tissue, and then a second mode in which lower-density RF energy desiccates tissue to produce hemostasis, as well as methods of performing electrosurgery using same. Devices formed in accordance with the principles of this invention may be used for any surgical procedure in which highly vascular tissue is cut electrosurgically in a dry or semi-dry field, examples of which include tonsillectomy, liver resection, and cosmetic procedures such as breast augmentation, breast reduction, breast mastopexy, and abdominoplasty.

The invention provides a method for establishing a tumor excision margin distance field model, and aims to solve the problems of high surgical risk and long surgical time in a liver tumor excision process in the prior art. The invention provides a method for defining a tumor incisal margin distance field, which comprises the following steps of: S1, acquiring imaging data of a patient, and establishing a model of a relative position relationship between a tumor and each tissue; s2, calling relative position information between the tumor and each tissue to judge the resection property of the tumor, if so, entering step S3, and if not, ending; s3, establishing an envelope surface according to the outer contour information of the tumor surface; and S4, determining a cutting edge surface and an edge distance field according to the envelope surface. The model is established to simulate the relative position relation of the tumor in the human body, and meanwhile, the risk in the operation is reduced, and the operation duration is shortened. The invention further discloses application of the defining method of the tumor excision margin distance field to positioning of the distance between a scalpel and a tumor in the liver resection operation process. The invention further discloses a system for establishing the tumor incisional margin distance field.

The invention discloses a method for representing a residual liver proportion in a liver resection operation. The method comprises the following steps of Step 1, performing multi-layer scanning on a human liver part through X-ray medical auxiliary equipment to obtain multi-layer CT data of the liver; Step 2, importing the CT data into a software, and converting the CT data into three-dimensional parameters of the liver stereoscopic model by the software; Step 3, fitting the converted three-dimensional parameters of the liver three-dimensional model to generate a liver three-dimensional model, and meanwhile, performing multi-section partitioning on the liver three-dimensional model by means of a partitioning function and completing partitioning calibration; and Step 4, determining a liver resection plan scheme according to the lesion position, completing simulated resection in the liver three-dimensional model by means of a software, then completing calculation of the residual liver proportion through a region calculation function, and evaluating the feasibility of the resection scheme through calculation. Reconstruction of a liver model and characterization of the residual liver proportion are realized by combining a region calculation function and a liver eight-section partition recognition function and embedding a Mimics software.

Herein disclosed are dual-mode electrosurgical devices designed to function in a first mode in which high-density RF energy is used to cut or vaporize tissue, and then a second mode in which lower-density RF energy desiccates tissue to produce hemostasis, as well as methods of performing electrosurgery using same. Devices formed in accordance with the principles of this invention may be used for any surgical procedure in which highly vascular tissue is cut electrosurgically in a dry or semi-dry field, examples of which include tonsillectomy, liver resection, and cosmetic procedures such as breast augmentation, breast reduction, breast mastopexy, and abdominoplasty.

The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A2A adenosine receptors (ARs).

The invention provides a method for improving the growth rate of a liver tissue induced by ALPPS, and relates to the technical field of medical researches. The method for improving the growth rate ofthe liver tissue induced by the ALPPS simultaneously performs liver resection on male rats by different surgical methods, then treats the rats in a traditional group, a modified group and a modified group B, continues to follow up after an operation and carry outs the injection of relevant impact factors. The method for improving the growth rate of the liver tissue induced by the ALPPS injects a related protein which promotes liver regeneration in the rats in the traditional group and the modified group within a certain period of time after the operation, conducts lethal treatment on the ratsat a plurality of time points, conducts assessment on the liver regeneration situation, allows an observer to clearly and visually obtain changes in the growth rate of the liver tissue, thereby further assisting the observer to perform more detailed numerical control to obtain complete data, and has the advantages of simple operation, short operation time, short data collection cycle and the like.

The invention relates to the technical field of medical biological detection, in particular to an application of serum HBV pgRNA in preparation of a kit for predicting postoperative recurrence and postoperative survival of hepatitis B related liver cancer. The invention also provides a kit for predicting postoperative recurrence and postoperative survival of liver cancer by utilizing quantitative PCR detection of HBV pgRNA in preoperative serum of hepatitis B related liver cancer patients. The marker is high in clinical reference value and credibility, not only can predict liver cancer recurrence and postoperative survival conditions of hepatitis B related liver cancer patients after liver resection, but also can early recognize postoperative patients prone to recurrence, and intervention treatment can be carried out in advance. The kit and the detection method disclosed by the invention are simple, convenient, reliable, short in period, high in specificity and easy to clinically popularize.

The invention discloses a cannula puncture needle for laparoscopic liver resection. The cannula puncture needle comprises a main body, a handle, a sleeve cylinder, a gas valve, a sleeve pipe, a thread, an outlet, a puncture needle, a supporting mechanism and a connecting mechanism. The thread is formed at the rear end of the outer diameter surface of the sleeve pipe, and the supporting mechanism is mounted on the outer diameter of the thread. After the puncture needle is inserted into the body of a patient, a knob is rotated and thus a ball bearing inside a through hole moves on the thread, then the supporting mechanism can move downward, the skin of the patient is pressed down by a fixing cylinder at the lower end of a connecting rod, a silicone layer is arranged at the bottom of the fixing cylinder, provides stable support after being contacted and is not easy to slip, a ventilation effect is achieved through a gas port and a venting hole, the fixing effect is good, the connecting mechanism is arranged at a position where the lower end of the handle and the puncture needle are connected, an insertion rod in the middle of a rod body is pushed out, and insertion blocks in two setsof fixing rods can be separated from insertion slots, and thus a convenient and quick effect is achieved; during installation, the two sets of fixing rods are connected and the insertion rod is inserted directly simply to facilitate the reuse of the handle.

The invention relates to a method for promoting the growth of mice liver implanted tumor after partial hepatectomy. The method comprises the following steps: culturing a mice liver cancer cell line, establishing a nude mice scapular region implanted tumor, establishing a mice different-ratio liver resection model, and establishing a mice liver implanted tumor model; and inoculating a tumor tissueblock after the parital hepatectomy, and injecting an Hh signal inhibitor every day after the inoculation. The scheme of the invention proves that the liver regeneration Hh signal channel after the hepatectomy can also promote the growth of the liver implanted tumor, prompts that the Hh signal channel can become a novel target point of the reoccurrence and transfer of the liver cancer, and can beused for further researching the effect of the Hh signal channel for preventing the reoccurrence of the liver cancer. The result of the invention has important significance for researching the reoccurrence prevention after the hepatectomy.

The invention discloses application of resina draconis to preparation of a medicine for treating acute liver injury caused by hepatectomy. According to the application, resina draconis is extracted and purified with 85% ethanol twice and reduced-pressure recovery is performed to obtain fluid extract, the concentrate is spray-dried and screened by a 120-mesh screen to obtain resina draconis extract powder, the resina draconis extract powder is suspended in CMC-Na or dissolved with 1%-50% glycerol, filtering is performed by a 0.2mu m filter membrane to obtain a medicine preparation, the medicine preparation is orally administered or injected at a dosage of 0.1-5mg / kg weight, liver function index detection is performed to observe the liver tissue repairing condition, and the results show that the liver function is restored to be normal, so that the resina draconis has the effect of promoting the repairing of liver injury caused by hepatectomy.

The invention provides a construction method of a hepatocellular carcinoma patient postoperative recurrence prediction model. The invention systematically studies the expression and distribution of eight NKG2D ligands (MICA, MICB and ULBP1-6) in HCC, and finds that MICA, MICB and ULBP4 are highly expressed in HCC tissues, and ULBP3 possibly plays an important role in HCC progress. The result shows that the NKG2D-CAR-NK cell with high affinity can be constructed in the HCC by targeting the MICB. The RFS prediction model based on MICA, ULBP3 and ULBP5 can predict recurrence of liver cancer patients after liver resection, and possibly has potential clinical value.

The invention discloses a cannula puncture needle for laparoscopic liver resection. The cannula puncture needle comprises a main body, a handle, a sleeve cylinder, a gas valve, a sleeve pipe, a thread, an outlet, a puncture needle, a supporting mechanism and a connecting mechanism. The thread is formed at the rear end of the outer diameter surface of the sleeve pipe, and the supporting mechanism is mounted on the outer diameter of the thread. After the puncture needle is inserted into the body of a patient, a knob is rotated and thus a ball bearing inside a through hole moves on the thread, then the supporting mechanism can move downward, the skin of the patient is pressed down by a fixing cylinder at the lower end of a connecting rod, a silicone layer is arranged at the bottom of the fixing cylinder, provides stable support after being contacted and is not easy to slip, a ventilation effect is achieved through a gas port and a venting hole, the fixing effect is good, the connecting mechanism is arranged at a position where the lower end of the handle and the puncture needle are connected, an insertion rod in the middle of a rod body is pushed out, and insertion blocks in two setsof fixing rods can be separated from insertion slots, and thus a convenient and quick effect is achieved; during installation, the two sets of fixing rods are connected and the insertion rod is inserted directly simply to facilitate the reuse of the handle.

The invention relates to an in vitro method of determining a subjects risk of liver dysfunction, specifically after partial liver resection, said method comprising the steps of providing a sample from said subject, determining in said sample the expression level of at least one miRNA, selected from the group consisting of miR-151a, miR-192 and miR-122, and comparing these expression level(s) with at least one reference expression level, or identifying the ratios of the expression levels of miR-15 la to miR-192 and / or of miR-122 to miR-151a and comparing said expression level ratios with reference expression level ratios, and classifying the sample from the outcome of the comparison into one of at least two classes, wherein each class is one of the at least two categories “high-risk” and “low-risk”.

A laparoscopic liver resection device is described. The device combines the Radiofrequency Ablation (RFA) technology with a cutting mechanism, a blood-flow sensor and a flexible actuation mechanism to simultaneously coagulate and cut the liver tissue and detect the presence of blood flow to confirm avascularity. The present invention eliminates the risk of excess bleeding due to cutting too deep and reduces recovery time and the time spent on re-coagulation of coagulated areas, thereby shortening duration of surgery. Also embodiments prevent excess ablation by stopping ablation activity on the target tissue as soon as insufficient or no blood flow in the target tissue is detected. Thus a closed loop control for a bloodless tissue / organ division method is provided.

The invention relates to the technical field of microorganisms, and discloses an application of lactobacillus plantarum AR113 in promoting liver regeneration. The invention provides a new application of lactobacillus plantarum AR113 in promoting liver regeneration and liver function recovery after liver partial resection, which comprises the following steps: evaluating the liver regeneration capacity after resection, observing and comparing pathological sections, detecting a liver cell regeneration marker ki67, detecting important regulatory factors of liver regeneration and the like, and verifying that compared with a control group, the lactobacillus has obvious activity of promoting liver regeneration; meanwhile, the evaluation on the liver function verifies that the lactobacillus plantarum can also promote the liver function recovery of the injured liver, and the experimental conclusion shows that the lactobacillus plantarum AR113 can provide appropriate probiotics for the liver resection patient to adopt special nutrition support in the perioperative period and promote the liver regeneration capacity and the liver function recovery.

A laparoscopic staged hepatectomy using round-the-liver ligation is carried out includes: (1) a laparoscopic operation is performed with general anesthesia using round-the-liver ligation, the branches of the portal vein of the hemiliver are ligated, a tourniquet is used to tighten the connecting part between the right and left hemilivers to block the communicating blood flow between the hemiliver to be removed and the hemiliver to be reserved, a drainage tube is put into the peritoneal cavity, then close the peritoneal cavity; (2) the patient gradually resumes eating after the first operation, and recuperate to make the volume of the hemiliver increase to an expected volume; (3) after the hemiliver increases to the expected volume, a laparoscopic liver resection is carried out with general anesthesia to remove the diseased hemiliver, and then the patient is nursed to be completely recovered. An instrument for implementing the laparoscopic staged hepatectomy is also disclosed.

The invention relates to a clinical prognosis prediction model before surgical operation of initial non-resectable hepatocellular carcinoma, and belongs to the technical field of biological medicine. The prediction model is a Nomogram model constructed based on Cox regression analysis of pre-surgical data; the model comprises five key influence factors including SLR prealpha fetoprotein, the number of cancerous lesions, portal vein cancerous embolus, the maximum diameter of a main tumor and tumor load change after TACE treatment. Through the SLR pre-operation selection of the prognosis prediction model for initial non-resection HCC in TACE + SLR treatment, people which can better survive and benefit from SLR can be screened out, and clinical guidance is provided for selection of patients suitable for remedy liver resection after TACE treatment; and accurate and individualized long-term survival prediction can be carried out on HCC patients who are ready to receive remedial liver resection treatment before surgical operation, so that more accurate individualized treatment of liver cancer is facilitated.