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Method for improving growth rate of liver tissue induced by ALPPS

A growth rate and liver tissue technology, applied in the field of medical research, can solve the problems of difficult adjustment of the operation time of the second operation, the inability of patients to receive timely treatment, and the delay of the second operation time, so as to achieve short data collection cycle and short operation time. Short, easy-to-use effects

Inactive Publication Date: 2019-05-14
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the influence of the patient's own postoperative physical condition, it is difficult to adjust the operation time of the second operation, and the liver itself will not be able to quickly regenerate to the ideal state in a short period of time, resulting in a delay in the second operation time, which in turn makes the patient unable to receive timely treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] S1. Select several healthy SPF grade male adult rats and SPF grade male aged rats.

[0025] In this embodiment, the body weight of the selected healthy rats is between 190g-195g. Preferably, there are 80 healthy adult rats and 40 aged rats.

[0026] S2. Divide 80 male adult rats in S1 into four groups, which are traditional group 1, traditional group 2, improved group 1 and improved 2 groups, and 40 male aged rats are divided into traditional group A and group A. Improved Group B.

[0027] S3. After the male rats in S1 were separated into groups in S2, they were uniformly placed in an animal room with constant temperature and humidity, provided with standard feed and clean water and fed freely for 12 hours, and the rats were deprived of water for 12 hours before the operation.

[0028] S4. Rapidly induce anesthesia on all rats before the operation and continue until the end of the operation.

[0029] In this embodiment, the classical method was used for liver resecti...

Embodiment 2

[0040] S1. Select several healthy SPF grade male adult rats and SPF grade male aged rats.

[0041] In this embodiment, the body weight of the selected healthy rats is between 195g-200g. Preferably, 100 healthy adult rats and 60 aged rats.

[0042] S2. Divide 80 male adult rats in S1 into four groups, which are respectively traditional group 1, traditional group 2, improved group 1 and improved 2 groups. At the same time, 60 male aged rats are divided into traditional group A and group A Improved Group B.

[0043] S3. After the male rats in S1 were separated into groups in S2, they were uniformly placed in an animal room with constant temperature and humidity, provided with standard feed and clean water and fed freely for 12 hours, and the rats were deprived of water for 12 hours before the operation.

[0044] S4. Rapidly induce anesthesia on all rats before the operation and continue until the end of the operation.

[0045] In this embodiment, the classical method was used ...

Embodiment 3

[0056] S1. Select several healthy SPF grade male adult rats and SPF grade male aged rats.

[0057] In this embodiment, the body weight of the selected healthy rats is between 190g-195g. Preferably, there are 60 healthy adult rats and 30 aged rats.

[0058] S2. Divide 80 male adult rats in S1 into four groups, which are respectively traditional group 1, traditional group 2, improved group 1 and improved 2 groups. At the same time, 30 male aged rats are divided into traditional group A and group A Improved Group B.

[0059] S3. After the male rats in S1 were separated into groups in S2, they were uniformly placed in an animal room with constant temperature and humidity, provided with standard feed and clean water and fed freely for 12 hours, and the rats were deprived of water for 12 hours before the operation.

[0060] S4. Rapidly induce anesthesia on all rats before the operation and continue until the end of the operation.

[0061] In this embodiment, the classical method ...

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Abstract

The invention provides a method for improving the growth rate of a liver tissue induced by ALPPS, and relates to the technical field of medical researches. The method for improving the growth rate ofthe liver tissue induced by the ALPPS simultaneously performs liver resection on male rats by different surgical methods, then treats the rats in a traditional group, a modified group and a modified group B, continues to follow up after an operation and carry outs the injection of relevant impact factors. The method for improving the growth rate of the liver tissue induced by the ALPPS injects a related protein which promotes liver regeneration in the rats in the traditional group and the modified group within a certain period of time after the operation, conducts lethal treatment on the ratsat a plurality of time points, conducts assessment on the liver regeneration situation, allows an observer to clearly and visually obtain changes in the growth rate of the liver tissue, thereby further assisting the observer to perform more detailed numerical control to obtain complete data, and has the advantages of simple operation, short operation time, short data collection cycle and the like.

Description

technical field [0001] The invention relates to the technical field of medical research, in particular to a method for increasing the growth rate of liver tissue induced by ALPPS. Background technique [0002] The liver has a strong metabolic function and regenerative ability, but under normal physiological conditions, most of the liver cells are in a resting state, and after liver damage such as infection, poisoning, or major liver resection and other stimuli, the liver cells will quickly start to regenerate. It shows amazing regenerative ability and functional compensatory ability, which makes it possible to restore the structure and function of the liver to normal levels after living donor liver transplantation. [0003] Among them, for patients with liver cancer, complete resection of liver cancer is the most important way for patients to obtain radical treatment, and sufficient residual liver volume after resection is a necessary condition to avoid liver failure. In ord...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/071
Inventor 于剑田虎付真张玲玲
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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