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Application of resina draconis to preparation of medicine for treating acute liver injury caused by hepatectomy

A technology for acute liver injury and dragon's blood, which is applied in the fields of pharmacology and natural medicinal chemistry, can solve the problems such as no dragon's blood, and achieve the effect of regeneration and repair of liver function and repair of liver function

Inactive Publication Date: 2016-09-21
胡炜彦 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the role of dragon's blood in the repair of liver injury after 2 / 3 hepatectomy

Method used

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  • Application of resina draconis to preparation of medicine for treating acute liver injury caused by hepatectomy
  • Application of resina draconis to preparation of medicine for treating acute liver injury caused by hepatectomy
  • Application of resina draconis to preparation of medicine for treating acute liver injury caused by hepatectomy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 5 kg of dragon's blood was extracted with 75-100% ethanol, and recovered under reduced pressure to obtain 4.375 kg of liquid extract. The liquid extract was spray-dried, and 4.174kg of the extract powder of the stink pill was obtained by sieving through a 120-mesh sieve. Take 0.5kg of dragon's blood extract powder, suspend it with 1% CMC-Na, and make it 200mg / mL. On the day before the hepatectomy and on the 1st, 2nd, 3rd, 4th, 5th, 6th, 7th, 8th, 9th, and 10th day after the operation, the model mice (0.2mL / 20g) were administered orally. On the day of the operation and on the 2nd, 4th, 6th, 8th, and 10th day after the operation, weigh the mice, take the blood of the mice, and test the liver function indicators. At the same time, kill the mice, take out the mouse livers, weigh them, and measure the liver weight of the mice. / weight ratio. The results of mouse body weight changes see figure 1 ; mouse liver weight / body weight ratio see figure 2 ; mouse plasma total pro...

Embodiment 2

[0044] 4.6 kg of dragon's blood was extracted with 75-100% ethanol, and recovered under reduced pressure to obtain 4.126 kg of liquid extract. The liquid extract was spray-dried, and sieved through a 120-mesh sieve to obtain 4.012 kg of the extract powder. Take 0.5kg of dragon's blood extract powder, dissolve the dragon's blood extract powder in 10% glycerin, make it 200mg / mL, filter it with a 0.2μm filter membrane, and put it on the day before the operation and on the 1st, 2nd, and 3rd day after the operation. , 4, 5, 6, 7, 8, 9, 10 days, orally administered to model mice (0.1mL / 20g). On the day of the operation and on the 2nd, 4th, 6th, 8th, and 10th day after the operation, weigh the mice, take the blood of the mice, and test the liver function indicators. At the same time, kill the mice, take out the mouse livers, weigh them, and measure the liver weight of the mice. / weight ratio. The results of mouse body weight changes see Figure 8 ; mouse liver weight / body weight r...

Embodiment 3

[0048] Tablet: extract 5 kg of dragon's blood through 75-100% ethanol, recover under reduced pressure, and obtain 4.375 kg of liquid extract. Spray-dry the liquid extract, pass through a 120-mesh sieve to obtain 4.174kg of dragon's blood extract powder, take 10mg of dragon's blood extract powder, 180mg of lactose, 55mg of starch, 5mg of magnesium stearate, lactose and starch, mix, and evenly moisten with water 1. The wetted mixture is sieved and dried, and then sieved, magnesium stearate is added, and the mixture is compressed into tablets, each tablet weighs 250 mg, and the compound content is 10 mg.

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Abstract

The invention discloses application of resina draconis to preparation of a medicine for treating acute liver injury caused by hepatectomy. According to the application, resina draconis is extracted and purified with 85% ethanol twice and reduced-pressure recovery is performed to obtain fluid extract, the concentrate is spray-dried and screened by a 120-mesh screen to obtain resina draconis extract powder, the resina draconis extract powder is suspended in CMC-Na or dissolved with 1%-50% glycerol, filtering is performed by a 0.2mu m filter membrane to obtain a medicine preparation, the medicine preparation is orally administered or injected at a dosage of 0.1-5mg / kg weight, liver function index detection is performed to observe the liver tissue repairing condition, and the results show that the liver function is restored to be normal, so that the resina draconis has the effect of promoting the repairing of liver injury caused by hepatectomy.

Description

technical field [0001] The invention belongs to the fields of natural medicinal chemistry and pharmacology, and in particular relates to the application of dragon's blood in the preparation of a medicine for treating acute liver injury after hepatectomy Background technique [0002] According to the statistics of the World Health Organization: 350 million people in the world suffer from liver disease, and liver disease causes more than 1 million deaths every year. In my country, there are about 30 million liver disease patients, and about 2 million new liver disease patients are added every year. In recent years, the incidence of liver cirrhosis and liver cancer caused by chemical factors and biological factors (such as hepatitis virus) has been increasing year by year. Regional resection of the diseased liver is an important means of treatment for such diseases. After partial liver resection or extensive liver resection, how to effectively repair liver damage is the key to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P1/16
CPCA61K36/896A61K2236/333A61K2236/51A61K2236/53
Inventor 胡炜彦张荣平赵荣华贺智勇于浩飞李菊张兰春
Owner 胡炜彦
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