6 results about "Hepatectomy" patented technology

The invention relates to a construction method of a model for preoperative evaluation of postoperative complications of hepatic resection. Performing high-order interactive modeling on the plurality of preoperative characteristic variables, and identifying the potential influence of the multi-factor joint effect on the postoperative complications; comprising the interaction between hepatic insufficiency and diabetes and the relationship between preoperative anemia and malnutrition; using a decision tree model to screen out features matched with the complication risk by calculating each variable and interaction item; for the modeling of the nonlinear relationship between the variables, capturing the nonlinear relationship between the variables by adopting a support vector machine (SVM) method; the prediction of the increase of the preoperative liver hardness is in a non-linear relationship with the risk of postoperative complications; constructing a multi-level regression model including hierarchical Bayesian regression, performing risk assessment on different levels including an individual level and a group level, and integrating individual differences and group features of patients; and each layer of model independently evaluates different risk factors, and integrates data of different layers for prediction.

Methods and uses of increasing or accelerating liver regeneration in a subject in need thereof are provided. In some aspects, such methods and uses comprise administering an effective amount of an androgen receptor inhibitor to a subject in need thereof, including, but not limited to, a subject suffering from one or more risk factors of post-hepatectomy liver failure. Any androgen receptor is contemplated for use in the methods described herein including, but not limited to, enzalutamide, apalutamide, bicalutamide, darolutamide, flutamide, nilutamide, or proxalutamide.

The utility model discloses a hepatic parenchyma blood flow blocking and lifting device used in hepatic resection, which comprises a soft ring, one side of the soft ring is fixedly connected with an air bag, the outer side of the air bag is fixedly connected with an outer fixing soft ring, one side of the outer part of the air bag is fixedly connected with a first mounting seat, and the first mounting seat is fixedly connected with a second mounting seat. One side of the first mounting seat is fixedly connected with a second mounting seat, one end of the second mounting seat is fixedly connected with a third mounting seat, and one side of the third mounting seat is fixedly connected with a gas injection lifting belt. The air injection lifting belt comprises a focus, the tightness of the soft ring is adjusted by injecting air into the air bag through a medical injector, partial hepatic blood flow blocking is achieved, a surgical assistant can clamp the traction base of the air injection lifting belt through a common surgical operation instrument, multi-directional lifting traction is conducted on the liver, and the focus can be conveniently exposed.

The application discloses a kind of microfiber scaffolds, organoid tissue patches and preparation method and application thereof.The microfiber scaffold is prepared using melt electrospinning process, by introducing stepwise translation deposition path in the same deposition plane, so that the continuous deposition of multiple microfibers forms stable convergence node structure at predetermined position, thereby constructing microfiber network with regular pore and continuous support topology.The stepwise translation deposition includes at least one repeated deposition with preset in-plane offset after the completion of the first pass fiber deposition, to reduce the electrostatic interference between fibers and promote node formation.The scaffold structure is stable, open and thin, suitable as a tissue engineering support structure.The application also provides an organoid tissue patch composed of the scaffold loaded organoids and a construction method thereof, which can be used to cover tissue injury interface, such as post-hepatectomy section repair.

This invention discloses the application of PIEZO1 inhibitors in the preparation of drugs to inhibit liver regeneration. Specifically, this invention relates to the application of the PIEZO1-specific inhibitor Dooku1 in the preparation of drugs to inhibit liver regeneration after hepatectomy. This invention also provides the application of Dooku1 in the preparation of reagents for constructing animal models of liver aplastic disorder. Experiments of this invention show that administration of Dooku1 significantly reduces the liver weight / body weight ratio, inhibits hepatocyte proliferation (significantly decreasing Ki67 positivity rate), and is accompanied by an increase in serum ALT and AST levels, successfully constructing a target-specific and reproducible animal model of liver aplastic disorder. This invention is the first to apply PIEZO1 inhibitors to inhibit liver regeneration, filling the technological gap in negatively regulating liver regeneration through inhibition of the PIEZO1 pathway, and providing potential candidate drugs and intervention strategies for pathological conditions requiring inhibition of abnormal liver hyperplasia after liver transplantation and hepatectomy.

The application discloses a biomarker of liver ischemia-reperfusion injury based on proteomics, and the biomarker is neutrophil granule protein (NGP), which can be used for early diagnosis and prevention of post-hepatectomy complications, prognosis monitoring and judgment, etc.