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Traditional Chinese medicine composition for protecting chemical liver injury and promoting liver regeneration as well as preparation method and application thereof

A technology of chemical liver injury and protective effect, applied in the field of traditional Chinese medicine composition for liver regeneration, can solve the problems of high cost, limited application of liver protection products, unstable supply of raw materials, etc., to achieve improved quality, significant liver protection, shorten The effect of sobriety time

Active Publication Date: 2021-11-26
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the products with hepatoprotective effect on the market use Cordyceps, pine pollen, Ganoderma lucidum, etc. as medicines, which have the problems of high cost and unstable supply of raw materials, which limits the application of related hepatoprotective products

Method used

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  • Traditional Chinese medicine composition for protecting chemical liver injury and promoting liver regeneration as well as preparation method and application thereof
  • Traditional Chinese medicine composition for protecting chemical liver injury and promoting liver regeneration as well as preparation method and application thereof
  • Traditional Chinese medicine composition for protecting chemical liver injury and promoting liver regeneration as well as preparation method and application thereof

Examples

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Effect test

preparation example Construction

[0049] Preparation of Refined Flammulina velutipes polysaccharide

[0050] In this example, the polysaccharides of Flammulina velutipes were extracted by microwave extraction, and purified and separated by D101 macroporous resin and DEAE-52 cellulose to obtain refined Flammulina velutipes polysaccharides with high purity and uniform molecular weight, as follows:

[0051] ①Microwave extraction of crude polysaccharides from Flammulina velutipes: After drying Flammulina velutipes, crush them to 100 meshes, use 15 times the amount of medicinal materials (w / w) as a solvent for extraction, and place them in a microwave extractor with a microwave power of 500W and an extraction temperature of 70°C. The extraction time is 40 minutes; collect the ultrasonic and microwave extract, filter, concentrate under reduced pressure to one tenth of the original volume, add 95% ethanol to the concentrated solution to make the final concentration of ethanol 80%, let it stand overnight, and collect t...

Embodiment 1

[0061] The traditional Chinese medicine composition with liver protection and regeneration effect is prepared, which is a mixture of traditional Chinese medicine extract and ultrafine powder. The preparation steps are as follows: ① Pueraria root, astragalus root, schisandra chinensis, and Hovenia dulcis fruit are respectively crushed into coarse powders, and 10 times the amount of medicinal materials ( w / w) concentration of 70% ethanol aqueous solution, extracted twice at 90°C for 2 hours each time, combined extracts, filtered, concentrated under reduced pressure, dried to make Chinese medicine extract powder, and extracted from kudzu root according to the prescription 5 parts of astragalus extract, 2 parts of astragalus extract, 2 parts of schisandra extract, and 4 parts of Hovenia dulcis fruit extract; ② take 1 part of the refined Flammulina velutipes polysaccharide with high purity and uniform molecular weight prepared above; ③ 1 part of Poria cocos, 1 part of amomum 1 part,...

Embodiment 2

[0063] The traditional Chinese medicine composition with liver protection and regeneration effect is prepared, which is a mixture of traditional Chinese medicine extract and ultrafine powder. The preparation steps are as follows: ① Pueraria root, astragalus, schisandra, and Hovenia dulcis are respectively crushed into coarse powder, and each uses 8 times the amount of medicinal materials ( w / w) concentration of 80% ethanol aqueous solution, extracted twice at 90°C for 2 hours each time, combined extracts, filtered, concentrated under reduced pressure, dried to make Chinese medicine extract powder, and extracted from kudzu root according to the prescription 8 parts of astragalus extract, 3 parts of astragalus extract, 3 parts of schisandra extract, and 3 parts of Hovenia dulcis fruit extract; ②Take 2 parts of the above-mentioned high-purity, uniform molecular weight refined enoki mushroom polysaccharide; ③1 part of licorice is crushed into a coarse powder , mix the coarse powder...

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Abstract

The invention discloses a traditional Chinese medicine composition for protecting chemical liver injury and promoting liver regeneration as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 5 to 20 parts of radix puerariae extract, 2 to 10 parts of radix astragali seu hedysari extract, 2 to 8 parts of fructus schizandrae extract, 1.5 to 20 parts of semen hoveniae extract and 0.5 to 2 parts of refined flammulina velutipes polysaccharide, and is supplemented with radix salviae miltiorrhizae, ampelopsis grossedentata, poria cocos, fructus amomi, moringa seed and liquorice root. Animal experiment research proves that the composition has a protective effect on acute liver injury caused by alcohol and carbon tetrachloride and can relieve liver injury. The composition can also induce liver cell proliferation and promote liver regeneration after liver resection injury.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine composition capable of protecting the chemical liver injury and regenerating the liver, a preparation method and an application thereof. Background technique [0002] The liver is the largest digestive gland with the most functions in the human body. It participates in the processes of digestion, metabolism, excretion, detoxification and immunity in the body, among which the metabolic function is the most important. It also participates in the hematopoietic process, stores and releases hematopoietic factors, and synthesizes various Enzymes, to ensure the normal metabolism of the human body. The liver has a powerful detoxification function for foreign substances and harmful substances produced by metabolism. However, many harmful factors can enter the liver through the portal vein or systemic circulation of the gastroin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/72A61K36/79A61K36/9064A61P1/16C08B37/00A61K31/715
CPCA61K36/488A61K36/481A61K36/79A61K36/57A61K36/72A61K31/715A61K36/537A61K36/87A61K36/076A61K36/9064A61K36/185A61K36/484A61P1/16C08B37/0003A61K2236/333A61K2236/51A61K2236/15A61K2236/39A61K2300/00
Inventor 徐希明孙从永余江南
Owner JIANGSU UNIV
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