Construction method for dental implant biological activity surface

Abstract

The present invention relates to a dental implant surface biological activity constructing method which is characterized in that a layer of three-dimensional hole layer consisting of a titanium oxidebracket and phosphorite is constructed at a pure titanium surface by sand blasting technology and microarc oxidation-electrophoresis technology firstly; then nutrilit fibronectin (Fn) and bone morphogenic protein (BMP) which are related to the growth and development and regeneration of the bone are selected; according to the concept of tissue engineering biological bracket, the biological active molecules which has the chemiadsorption with the surface of the titanium oxide layer are deposited and solidified inside the microenvironment of the three-dimensional hole layer, so as to ensure that the surface of the implant can be induced and regulated into bone and be participated in the bone matrix substance exchange, which has the capability of rebuilding and self restoration required for being assorted and coexisted with organism for a long time, the physical-chemical-biological synostosis is formed, and the dental implant and bone tissue participate in the synostosis . The method greatly shortens the time for the synostosis of the dental implant and improves the capability and the success ratio that the dental implant is assorted and coexisted inside the body for a long time, whichhas the vital signs of artificial organ to a certain extent.

Description

technical field [0001] The invention belongs to the technical field of dental artificial implants. The invention relates to a treatment method for surface modification of dental implants, in particular to a treatment method for surface modification of dental implants which can greatly shorten the osseointegration time of dental implants and improve long-term coordination and coexistence ability and success rate. Background technique [0002] In recent years, artificial tooth implant technology has been widely used in economically developed countries in Europe and America, and has become the leading technology for oral dentition restoration. Compared with the traditional removable and fixed denture restoration technology, the artificial dental implant technology has an essential difference and obvious progress in the restoration concept. All countries have invested huge manpower and material resources in the research and development of new implants. The surface active treatm...

AI Technical Summary

Problems solved by technology

However, the recognized research results believe that the problem of coating peeling still exists [9], and the application of this type of implant will tend to be eliminated in general; 2. Further improve traditional techniques such as sandblasting and acid etching to modify the microscopic physical appearance of the implant surface and chemical components, forming a rough porous surface with good biocompatibility, and increasing the bonding area between the implant and bone tissue. This method has received good clinical results, to a certain extent, speeding up bone healing and improving The strength of osseointegration is studied. The representative research results are the Sand-blasted large-grit acid-etched (SLA) implants developed by the International Institute for Dental Implantology (ITI)[10,11]. Implant-like implants are more common in clinical medicine at home and abroad, but there is still a physical and mechanical combination between such implants and bone tissue.

In addition, in recent years, many scholars have used electrochemical oxidation technology to modify the surface of implants, so that the surface of pure titanium can be oxidized and converted into bioceramic materials, thereby greatly improving biocompatibility [12, 13, 14], This kind of research also belongs to the surface biological modification of non-coating. The representative research results are the TiUnite series of implant products [4, 15, 16] from Nobel Biocare, the world's largest dental implant research and development and production organization. Due to the good biocompatibility of the surface, the product shortens the osseointegration time to a certain extent and promotes the development of immediate repair technology [16], but it still cannot fully meet the clinical requirements for shortening the osseointegration time as much as possible. , and cannot meet the above-mentioned requirements of having the life characteristics of artificial organs

In addition, CN101138652A Chinese patent application discloses a method for preparing a composite material with a highly bioactive surface porous implant, which uses micro-arc oxidation treatment equipment to perform micro-arc oxidation treatment on titanium or titanium alloys in an electrolyte containing calcium and phosphorus , the thickness of the obtained ceramic oxide film on the surface of the implant is about 20 μm; CN101054708A patent application discloses a method for preparing hydroxyapatite bioceramic film by plasma micro-arc oxidation method, which uses different electrolytes and different processes parameters can be used to obtain hydroxyapatite bioceramic membranes with a thickness of 10-45 μm. The common disadvantages of these two methods are that the content of hydroxyapatite in the formed oxide layer is low, and it is a single-level three-dimensional structure, which is not conducive to biological activity. Cell attachment and osteogenesis; in addition, the method of simulating body fluids to adsorb biomacromolecules is time-consuming, inefficient, and easy to fall off

[0003] To sum up, the current research on artificial dental implants has not completely got rid of the form of bone healing in which bone tissue is unilaterally involved, and has not considered the long-term self-healing ability of dental implants, especially their surfaces, from the perspective of artificial organs.

Although some implant products have been continuously improved on the surface treatment technology to have a better bioactive surface layer, which can significantly improve the early bonding strength and shorten the osseointegration time[4,5], but for the increasing clinical requirements, such as immediate implantation There is still a considerable gap in the goal of immediate loading, and the maintenance of dynamic balance of osseointegration in the later stage is mainly unilaterally participated by the body tissue, lacking the initiative of the implant, and the initially formed osseointegration interface lacks the ability of dynamic reconstruction and self-repair, which is easy to Affected by pathophysiological factors (such as periodontitis, osteoporosis, and local bone resorption) and biomechanical factors (such as early loading fretting damage and implant design), some or all of the osseointegration is lost[6]