Influenza Hemagglutinin And Neuraminidase Variants

Abstract

Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to and benefit of U.S. Provisional Patent Application 60 / 659,832. This application also claims priority to U.S. patent application Ser. No. 10 / 870,690, filed on Jun. 16, 2004, which is a non-provisional application of U.S. Provisional Patent Application Ser. No. 60 / 479,078, the disclosures of which are incorporated herein in their entirety for all purposes.REFERENCE TO A SEQUENCE LISTING[0002]This application refers to a sequence listing, which is provided as an electronic document on each of two identical compact discs, labeled “Copy 1” and “Copy 2.” Each compact disk contains a 320,100 byte file entitled “FL2550US2_seqlist.txt,” created Mar. 6, 2006. This electronic sequence listing file is incorporated in its entirety herein.BACKGROUND OF THE INVENTION[0003]Vaccines against various and evolving strains of influenza are important from a community health standpoint, as well as commercially, since each yea...

AI Technical Summary

Benefits of technology

[0022]Methods of producing immunogenic responses in a subject through administration of an effective amount of any of the above viruses to a subject are also within the current invention. Additionally, methods of prophylactic or therapeutic treatment of a viral infection (e.g., viral influenza) in a subject through administration of one or more above described virus in an amount effective to produce an immunogenic response against the viral infection are also part of the current

Problems solved by technology

Infants, the elderly, those without adequate health care and immuno-compromised persons are at special risk of death from such infections.

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