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Methods for management of anticoagulation therapy

a technology for managing and anticoagulation therapy, applied in the field of management methods for anticoagulation therapy, can solve the problems of treatment failure or complications, difficult management of anticoagulants,

Inactive Publication Date: 2009-08-27
SWEDISH HEALTH SERVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]In another embodiment of such methods, the anticoagulant is warfarin. In another embodiment of such methods, the preselected list of doses corresponds to at least one mnemonic. In another embodiment of such methods, the previous time period and the next time period are one week. In another embodiment of such methods, the method further comprises inputting another anticoagulant pill size other than the current anticoagulant pill size before providing the new allocated dose....

Problems solved by technology

Because of a very complex pharmacology, anticoagulants may be difficult medications to manage.
Studies have shown that many patients are not optimally treated and these patients spend much of their time with suboptimal treatment, resulting in treatment failures or complications.

Method used

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  • Methods for management of anticoagulation therapy

Examples

Experimental program
Comparison scheme
Effect test

example 1

Program for Management of Anticoagulation Therapy

[0109]A program (100) for management of anticoagulation therapy was developed (FIG. 1). The program required input of four data points: INR value (for a current blood sample) (101); dose (of warfarin from the previous week) (102); INR target for treatment (either 2.0 to 3.0 or 2.5 to 3.5) (103); and pill size (104) (FIG. 2). Data points 101-104 were input into calculators 200 to produce a new dose regimen (400). More specifically, the program (100) accepted data points 101-103 into new dose calculator (200) to calculate a new dose (201). The new dose (201) along with pill size (104) was then sent to the Allocation Generator (300) to produce new dose regimen (400).

[0110]A new dose was generated by the new dose calculator (200) (FIG. 3). The new dose calculator sorted the INR reading (101) into an appropriate category 1.0-1.3, 1.4-1.6, 1.7-1.9, 2.0-3.0, 3.1-3.5, 3.6-4.0, 4.1-4.5, and >4.5. Based on the category of INR, and the INR targe...

example 2

Interface for Program for Anticoagulant Therapy

[0114]An interface for a program for anticoagulant therapy as described in Example 1 was created (FIG. 5). The interface was called up on a computer as a web page by entering in a URL. The program was embedded in the web page. Data was entered by typing into the boxes on the interface. In the first row, daily doses for the previous week were entered. In the second row, the current INR and INR goal were entered. In the fourth row, the pill size was entered. The colors of the boxes for pill sizes correspond to the colors of the respective warfarin pills.

[0115]The calculations were performed by pressing the buttons on the interface. The “current dose” button calculated the weekly cumulative dose and average daily dose. The “new dose” button calculated the new recommended dose, and the difference between the old dose and new recommended dose. The new warfarin dose was displayed after pressing the “new dose” calculation button, and provided ...

example 3

Clinical Management of Warfarin Dosing

[0117]A. S. is a 78-year-old white woman with atrial fibrillation. A. S. started on warfarin and after stabilization of her dose, her Protime / INR was checked once a month. On the first day, her INR was 1.6. Her warfarin dose was 4 mg on Mondays, Wednesdays, and Fridays and 2 mg on the remaining days of the week. Her INR, dose for the previous week, INR target, and pill size were inputted into the program described in Example 1. The program calculated A. S.'s new dose, which was 4 mg to be taken 6 days a week and 2 mg on Saturday. A. S.'s INR was taken 2 weeks later and was 2.8, within the target range.

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Abstract

Presented herein are methods for determining dosages of anticoagulants for a patient. Also presented herein are apparatuses for determining dosages of anticoagulants for a patient. Further presented herein are electronic medical records systems comprising a program for determining dosages of anticoagulants for a patient. Further presented herein are clinical decision support programs for determining dosages of anticoagulants for a patient. Further presented herein are virtual anticoagulation clinics for determining dosages of anticoagulants for a patient. Further presented herein are point of care anticoagulation devices for determining dosages of anticoagulants for a patient.

Description

CROSS-REFERENCE[0001]This application claims benefit of priority under 35 U.S.C. § 119(e) from provisional patent application 61 / 030,873, filed Feb. 22, 2008, which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION[0002]Anticoagulants are commonly used to treat thrombotic conditions, disorders of the coagulation that result in abnormal clot formation. Because of a very complex pharmacology, anticoagulants may be difficult medications to manage. Many factors affect the anticoagulant effect, for example, genetic factors, age, sex, diet, drug interactions, and illness, as well as patient compliance with recommended dosing schedules. The use of anticoagulants is widespread. Management has usually been through traditional physician visits, anticoagulation clinics, and rarely through self-management programs. In the case of traditional physician visits, there is a wide variation in the management approach, often dependent on individual experience or local pra...

Claims

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Application Information

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IPC IPC(8): G06Q50/00G16H10/60G16H20/10
CPCG06Q50/24G06Q50/22G16H10/60G16H20/10
Inventor WOO, WILLIAM
Owner SWEDISH HEALTH SERVICES
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