3 results about "Anticoagulant therapy" patented technology

The application discloses a kind of dabigatran bleeding risk prediction methods based on machine learning, it is related to computer-aided drug risk management technical field, the method is by obtaining patient baseline and follow-up data, multiple imputation method is handled missing value;With HAS-BLED score as the basis, candidate variables are screened from potential risk factors using LassoCV algorithm, and anemia, insulin use and antifungal agent use are determined as new prediction variables through clinical correlation analysis to construct a set of prediction variables;Finally, a random forest or gradient boosting algorithm is used to train the model to output the bleeding risk assessment results of the individual to be tested.The application combines machine learning algorithm, improves the prediction accuracy of dabigatran bleeding risk in Chinese non-valvular atrial fibrillation patients, solves the problem of insufficient prediction accuracy of traditional HAS-BLED score, and provides a more reliable basis for clinical individualized anticoagulant therapy decision.

A method and kit are provided for measuring and monitoring a combined effect of an anticoagulant drug on coagulation factors II and X in a patient taking the anticoagulant drug. The method includes adding one or more coagulation reagents with the factor VII to a test sample and determining blood clotability of the test sample by measuring an influence of factors II and X.

This invention discloses an arterial puncture hemostasis composite dressing and its preparation method. The dressing is prepared through electrospinning, impregnation, foaming, and lamination to obtain an outer protective layer, an adaptive pressure layer, and a skin-adhesive hemostasis layer arranged sequentially from top to bottom. The skin-adhesive hemostasis layer has a polysaccharide-based composite fiber structure, loaded with procoagulant, adhesive, and antifibrinolytic components, forming an adhesive gel layer upon contact with blood. The adaptive pressure layer is an elastic porous material layer containing liquid-absorbing and swelling particles that expand in volume after absorbing blood or body fluids, generating dynamic pressure. The outer protective layer is a transparent, breathable, and waterproof polyurethane membrane. The skin-adhesive hemostasis layer maintains liquid permeability, allowing some blood to be transferred to the adaptive pressure layer to trigger expansion. This invention achieves rapid and stable hemostasis through the synergistic effects of procoagulant, adhesive, and antifibrinolytic properties, as well as the adaptive pressure mechanism, making it particularly suitable for patients undergoing anticoagulation therapy.