Method of differentially diagnosing different types of dementia

a technology differential diagnosis, applied in the field of differential diagnosis of different types of dementia, can solve the problems of only being able to precisely differentiate alzheimer's disease, affecting the treatment effect, so as to achieve precise differentiation of alzheimer's disease and frontotemporal dementia, and patients suffering from lewy-body dementia are susceptible to neuroleptic agents

Inactive Publication Date: 2010-09-02
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0032]As for the manufacture of the afore-mentioned diagnostic composition or the method of data acquisition, the method of diagnosis may be performed using the above-described compounds. Compounds which have been mentioned above as being particularly suitable for use in the diagnostic compositions or for performing the method of data acquisition approach will also be considered to be useful for the method of diagnosis aspect of the invention.

Problems solved by technology

Dementia is a highly prevalent problem causing considerable disability and even mortality.
However, at present, precise differentiation of Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia is only possible by post-mortem analysis of brain tissue.
Patients suffering from Lewy-body Dementia are susceptible to neuroleptic agents.

Method used

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  • Method of differentially diagnosing different types of dementia
  • Method of differentially diagnosing different types of dementia

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Embodiment Construction

[0033]The inventor has surprisingly discovered that SPECT tracers can be used for differentially diagnosing degenerative dementias such as Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia in a single SPECT run. The invention is based on the finding that SPECT tracer distribution as measurable by perfusion analysis shortly after administration of the tracer and the SPECT tracer's localization as measurable after a longer period can be used to differentially diagnose the aforementioned degenerative dementia.

[0034]Before some of the embodiments of the present invention are described in more detail, th following definitions are introduced.

[0035]As used in the specification and in the claims, the singular forms of “a” and “an” also include the respective plurals unless the context clearly dictates otherwise.

[0036]The terms “about” and “approximately” in the context of the present invention generally denote a level or interval accuracy that a person skilled in the art ...

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Abstract

The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially diagnosing Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia.

Description

SUBJECT OF THE INVENTION[0001]The present invention relates to the field of diagnosing different types of dementia.BACKGROUND OF THE INVENTION[0002]Dementia is a highly prevalent problem causing considerable disability and even mortality. Among the most common forms of dementia are the three degenerative forms Alzheimer's disease (AD), dementia with Lewy bodies (also known as Lewy-Body Dementia (DLB)), and Frontotemporal Dementia (FTD). Various lines of research, including clinical, pathological, and genetic analysis indicate that the degenerative forms of dementia have different underlying etiologies and pathogenetic mechanisms.[0003]Given the presumably different mechanisms underlying the aforementioned types of dementia, future therapies will probably differ for each major form of degenerative dementia. The ability to differentially diagnose between[0004]Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia will be a major advantage not only for the individual pati...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K51/00A61K49/00A61K51/04C07F13/00C07D451/02
CPCA61K51/0448A61K51/0455
Inventor THIELE, FRANK OLAF
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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