N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds and their use

a technology of alkylcarbonyl-amino lactone and alkylcarbonyl-amino acid ester, which is applied in the field of refreshing, soothing and cooling compounds, can solve the problems of limited utility of menthol in relieving sensory discomfort, no compound currently known to the art has the potency or duration of action, and no other compound can achieve the effect of increasing alertness, reducing sleepiness and fatigue, and increasing alertness

Inactive Publication Date: 2011-04-07
WEI EDWARD T
View PDF2 Cites 33 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019]In one embodiment, the treatment is the relief of (e.g., alleviation of) ocular irritation, itch, and/or pain (e.g., wherein the contacting delivers an amount of the compound that is therapeutically effective for alleviation of irritation, itch, and/or pa

Problems solved by technology

Menthol's utility in relief of sensory discomfort is, however, limited by its short duration of action and by its multimodal actions on sensory processes—including odor, harshness of taste, and irritation.
The unpleasant effects of menthol can be easily experienced, for example, when menthol-containing ointment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds and their use
  • N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds and their use
  • N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds and their use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024]A class of compounds that is suitable to be used as an active ingredient in (e.g., pharmaceutical) preparations for use on the skin of the eyelids and on the ocular surface has been found.

[0025]These compounds are suitable, for example, for use as agents to reduce discomfort such as itch, a sense of dryness and irritation, and pain.

[0026]These compounds have one or more of the following properties:[0027](i) a refreshing, soothing, and cooling action on the surface of the skin and, in pathological states, act as an anti-irritant, anti-pruritic, and / or anti-nociceptive agent[0028](ii) a minimal irritant action on the eye when the compound is applied to facial skin near and on the ocular surface;[0029](iii) a rapid onset of action of less than 5 minutes, preferably less than 1 minute;[0030](iv) a duration of action that exceeds 1 hour, for example, when applied onto the upper eyelids at a concentration of 0.2 to 2 mg / ml in a towelette; and[0031](v) a robust cool, soothing, and re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to view more

Abstract

The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of increasing alertness, and decreasing fatigue or sleepiness, and alleviating ocular discomforts of irritation, itch, and pain.

Description

RELATED APPLICATIONS[0001]This application is a continuation-in-part of U.S. patent application 20080227857, filed Mar. 23, 2006, inventor Wei, entitled “N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use”, incorporated by reference.[0002]This application is related to:[0003]U.S. Provisional Application No. 60 / 667,166 filed 29 Mar. 2005;[0004]U.S. Provisional Application No. 60 / 683,384 filed 20 May 2005;[0005]U.S. Provisional Application No. 60 / 702,505 filed 26 Jul. 2005;[0006]U.S. patent application Ser. No. 11 / 203,728 filed 13 Aug. 2005; and[0007]U.S. Provisional Application No. 60 / 772,374 filed 9 Feb. 2006;[0008]the contents of each of which are incorporated herein by reference in their entirety.TECHNICAL FIELD[0009]The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester and N-alkylcarbo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/215C07C233/63A61P29/00A61P17/04
CPCC07B2200/07C07D307/33C07C2101/14C07C233/63C07C2601/14A61P1/02A61P1/08A61P11/00A61P11/06A61P11/14A61P17/00A61P17/04A61P17/06A61P25/00A61P25/34A61P29/00A61P3/00A61P31/04C07C233/05C07C233/08C07D277/24C07C243/38C07C255/57C07D213/86C07D307/68C07D307/84C07D307/85C07D333/38
Inventor WEI, EDWARD T.
Owner WEI EDWARD T
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap