Procalcitonin for the prognosis of adverse events

a technology of procalcitonin and adverse events, applied in the field of clinical diagnostics, can solve the problem that the level of procalcitonin or fragments thereof is correlated with the risk of the subject suffering from an adverse even

Inactive Publication Date: 2012-06-14
BRAHMS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, the level of procalcitonin or fragments thereof is correlated to a risk of the subject to suffer from an adverse event.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

examples

Study Population and Design

[0054]The study population was obtained from the Prevention of Renal and Vascular Endstage Disease (PREVEND) study. The PREVEND study was designed to investigate prospectively the natural course of albuminuria and its relation to renal and cardiovascular disease in a large cohort drawn from the general population (age ranged between 28 and 75 years) of the city of Groningen, the Netherlands. Details of the study design, recruitment, and procedures have been published elsewhere (Hiliege et al., Circulation 2002, 106:1777-1782; Hillege et al., J Intern Med 2001, 249:519-526; Mahmoodi et al., JAMA 2009, 301:1790-1797). The PREVEND study was approved by the local medical ethics committee, University Medical Center Groningen, and conformed to the principles outlined in the Declaration of Helsinki. All participants gave written informed consent.

Measurements

[0055]The participants underwent two outpatient visits to assess demographic, anthropometric, and cardiovas...

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PUM

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Abstract

The present invention relates to an in vitro method for the prognosis of an adverse event in asymptomatic subjects comprising the determination of the level of Procalcitonin (PCT) or a fragment thereof or a precursor or fragment thereof having at least 12 amino acid residues in a sample of a bodily fluid from said subject and the correlation of the determined level to a potential risk of sustaining an adverse event.

Description

FIELD OF THE INVENTION[0001]The present invention is in the field of clinical diagnostics. Particularly the present invention relates to the determination of the level of Procalcitonin (PCT) in a sample derived from a bodily fluid of a subject.BACKGROUND OF THE INVENTION[0002]Procalcitonin (PCT) is known as a biomarker, that reflects the presence and severity of local and systemic bacterial infections, i.e. sepsis (Assicot et al., Lancet 1993; 341:515-8; Muller et al., Crit Care Med 2000; 28:977-83.; Harbarth et al., Am J Respir Crit Care Med 2001; 164:396-402; Becker et al., Crit Care Med 2008; 36:941-52; Becker et al., J Clin Endocrinol Metab 2004; 89:1512-25; Nobre et al., Am J Respir Crit Care Med 2008; 177:498-505; Christ-Crain et al., Lancet 2004; 363:600-7; Stolz et al., Chest 2007; 131:9-19; Christ-Crain et al., Am J Respir Crit Care Med 2006; 174:84-93; Briel et al., Arch Intern Med 2008; 168:2000-7; discussion 7-8).[0003]During bacterial infections, plasma PCT concentratio...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/53
CPCG01N33/6893G01N2333/585G01N2800/50G01N2800/2871G01N2800/324G01N2800/042
Inventor STRUCK, JOACHIMBAKKER, S.J.L.
Owner BRAHMS GMBH
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