Extracts and beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-, (3s,6s)-

Inactive Publication Date: 2012-11-08
PRICE RANDY RAY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0025]The present invention provides extracts and beverages, in which compound A having an improving effect on learning motivation and being highly safe without side effects can be contained at a high content with Bx values remaining low. The extracts of the present invention can be added to beverages and so on without impairing the taste inherent to foods and beverages. The extracts or beverages of the present invention, as well as foods and beverages comprising the same can be ingested continuously over a long period of time as foods and beverages useful for improvement of learning motivation.

Problems solved by technology

In a highly complex modern society, a reduction of willingness turns into a problem.

Method used

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  • Extracts and beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-, (3s,6s)-
  • Extracts and beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-, (3s,6s)-

Examples

Experimental program
Comparison scheme
Effect test

example 1

Improving Effect of Compound a on Learning Motivation (1)

[0063]Compound A was evaluated for its enhancing effect on learning motivation by the method known in the art, i.e., Morris Water Maze (MWM).

[0064]First, water which had been colored black with Indian ink was filled into a cylindrical tank of 90 cm diameter and 35 cm height to give a water depth of 20 cm, and the water temperature was set to 22±1° C. To this tank, C57BL / 6 mice (male, 9 weeks of age) were each transferred and allowed to experience open space swimming (OSS). Upon OSS, mice will cause changes in their behavior and enter a state corresponding to depression. After repeating OSS for 5 days, the mice were divided into 7 groups.

[0065]Next, in the above cylindrical tank of 90 cm diameter and 35 cm height, an escape platform of 10 cm diameter was placed at a water depth of 0.5 cm. The above 7 groups of mice were each orally administered with compound A (Bachem AG (Bubendorf, Switzerland)) or with a comparative drug, flu...

example 2

Improving Effect on Learning Motivation (2)

[0067]In the same manner as shown in Example 1, mice were administered with 20 mg / kg compound A and then subjected to the MWM test. As a control, a linear dipeptide (Phe-Phe) was administered at 20 mg / kg, followed by the MWM test.

[0068]The results obtained are shown in FIG. 2. As can be seen from FIG. 2, the linear dipeptide (Phe-Phe) was not confirmed to have a significant effect, whereas compound A showed a significant improving effect on learning motivation over the control group (OSS-Saline). Namely, it is indicated that the cyclic dipeptide structure is required for exerting an improving effect on learning motivation.

example 3

Study on Starting Materials

[0069]As protein-containing starting materials, beef meat, pork meat, fish, quail meat, corbicula clam and chicken meat (Black Chicken, Chicken) were used. Each animal material was mixed with one volume of water and introduced into a container, followed by heat treatment in an autoclave at 135° C. for 4 hours (as a pretreatment step) and further at 135° C. for 4 hours (as a heating step). The heat-treated liquid was collected and eluted with acetonitrile from a pretreatment column (OASIS MAX (Waters: 30 mg / 1 cc)), followed by high performance liquid chromatography (HPLC) to quantify the content of compound A. Conditions for HPLC are as shown below. The results obtained are shown in FIG. 3.

[0070](HPLC Conditions)

[0071]System: Agilent 1100 series

[0072]Column: Develosil C30-UG-5 (4.6×150 mm, 5 μm)

[0073]Mobile phase A: water, Mobile phase B: 100% acetonitrile solution

Gradient:Time (min)Solvent B0.0020%9.0020%23.0028%24.0070%31.0070%31.1020%40.0020%

[0074]Inject...

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Abstract

The present invention aims to provide extracts or beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S)—, which is a useful substance with an improving effect on learning motivation, in an easy-to-ingest form and at a high concentration. Extracts or beverages whose ratio between the content of 2,5-piperazinedione,3,6-bis(phenyl-methyl)-,(3S,6S)— (unit: μg / 100 g) and Brix(Bx) is 6 (μg / 100 g) / Bx or more can be ingested continuously over a long period of time as foods and beverages useful for improvement of learning motivation.

Description

TECHNICAL FIELD[0001]The present invention relates to foods and beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S)—, and more particularly relates to extracts and beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S)— at a high concentration, wherein the pH is 5 or more.BACKGROUND ART[0002]In a highly complex modern society, a reduction of willingness turns into a problem. For example, the term “motivation crisis” is used to describe the problem of reduced motivation in young people. Moreover, it is said that depression patients often show symptoms of hypobulia, and there is a demand for the development of drugs capable of improving hypobulia.[0003]In recent years, a “dipeptide” composed of two amino acids attached to each other has received attention as a functional substance. Dipeptides can be designed to have additional physical properties and / or new functions, which cannot be seen in single amino acids, and hence they are expected to be app...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61P25/00A23L13/30A23L17/20A23L27/10
CPCA23L1/30A23L1/313A23L2/52A23V2002/00C07K5/06078C07D241/08A23V2250/204A23L33/10A23L13/30A61P25/00A61P25/24A61K9/20A61K9/48A23L2/66A61K9/0095A61K38/12
Inventor MATSUBAYASHI, HIDEKIYAMAMOTO, KENJIWATANABE, HIROSHIHONG, LEE KIAN
Owner PRICE RANDY RAY
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