Colon cancer targets and uses thereof
a colon cancer and target technology, applied in the field of molecular markers and therapeutic agents, can solve the problems of 37% of colorectal cancer diagnosis colon cancer remains difficult to diagnose and treat effectively,
Inactive Publication Date: 2013-03-14
CELERA CORPORATION
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
The present invention provides a method for diagnosing or detecting colon disease by measuring the level of certain proteins or peptides in a test sample from a subject. These proteins or peptides are differentially expressed in colon cancer and can be used as markers for diagnosis. The invention also provides methods for detecting these proteins or peptides in a biological sample, such as tissue or blood, and using them to diagnose or monitor the disease. The invention further provides a method for screening agents that modulate the activity of the proteins or peptides. Overall, the invention provides new tools for diagnosing and treating colon disease.
Problems solved by technology
The five-year survival rate for patients with colorectal cancer detected in an early localized stage is 92%; unfortunately, only 37% of colorectal cancer is diagnosed at this stage.
Recurrence following surgery (the most common form of therapy) is a major problem and is often the ultimate cause of death.
In spite of considerable research into therapies for the disease, colon cancer remains difficult to diagnose and treat.
Method used
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1. Colon Tissues and Cells
Colon Cell Line
TABLE-US-00002 [0371] TABLE 2 Cell line ATCC Catalog # SW1116 CCL-233 HT29 HTB-38 LS174T CL-188 LS 180 CL-187 SW480 CCL-228 CaCo-2 HTB-37 LS411N CRL-2159 RKO CRL-2577 Colo320DM CCL-220 HCT 15 CCL-225 HCT-116 CCL-247 LS1034 CRL-2158 LS513 CRL-2134 SNU-C2B CCL-250 SW1463 CCL-234 SW403 CCL-230 SW48 CCL-231 SW948 CCL-237 SW837 CCL-235 DLD-1 CCL-221 NCI-H548 CCL-249
Colon Cancer Cell Line Culture
[0372] Cell lines were grown in a culturing medium that is supplemented as necessary with growth factors and serum (as described in Table 2). Cultures were established from frozen stocks in which the cells were suspended in a freezing medium (cell culture medium with 10% DMSO [v / v]) and flash frozen in liquid nitrogen. Frozen stocks prepared in this way were stored in the liquid nitrogen vapour. Cell cultures were established by rapidly thawing frozen stocks at 37.degree. C. Thawed stock cultures were slowly transferred to a culture vessel containing a larg...
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Abstract
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001] This application is a divisional application of U.S. non-provisional application Ser. No. 13 / 108,674, filed May 16, 2011, which is a divisional application of U.S. non-provisional application of Ser. No. 12 / 077,323, filed Mar. 17, 2008 (issued as U.S. Pat. No. 7,960,100 on Jun. 14, 2011), which is a divisional application of U.S. non-provisional application Ser. No. 11 / 085,606, filed Mar. 22, 2005 (which is now abandoned), which claims priority to U.S. provisional application Ser. No. 60 / 566,425, filed Apr. 30, 2004, and U.S. provisional application Ser. No. 60 / 576,812, filed Jun. 4, 2004, the contents of each of which are hereby incorporated by reference into this application.FIELD OF THE INVENTION[0002] This invention relates to the fields of molecular biology and oncology. Specifically, the invention provides a molecular marker and a therapeutic agent for use in the diagnosis and treatment of colon diseases.BACKGROUND OF THE INVENTION...
Claims
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Login to View More IPC IPC(8): A61K39/395C12N15/12C12N15/52C12N15/113C12N5/12C12N1/19C12N1/21C12N5/10C12N5/071C12N5/09G01N33/566G01N33/574C40B30/04G01N33/53C12Q1/68C07K14/435C07K16/18A61K38/17A61P35/00A01K67/00C12N9/00
CPCC07K16/18G01N33/57419A61K38/00A61P35/00A61K39/00C07K14/47C07K16/3046C07K2317/734C12N15/113C12N2310/14C12Q1/6886C12Q2600/118C12Q2600/158
Inventor DOMON, BRUNOLI, AIQUNHE, TAOMCCAFFERY, IAN
Owner CELERA CORPORATION