Biosorbable endoprosthesis

Inactive Publication Date: 2014-10-30
MAGNUS FLOW
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]Although bioerodible stents are useful, they are not very effective at

Problems solved by technology

Biosorbable endoprostheses are not ve

Method used

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example

[0058]Magnetic particles suitable for use in the invention are constructed as follows, and loaded into PLGA to form nanoparticles. The resulting nanoparticles are sprayed onto a biosorbable stent (constructed from a magnesium alloy comprising 96 to 97.9% w / w of magnesium, 1.6 to 2% w / w of manganese and 0.5 to 2% w / w of a rare earth metal), to form a biosorbable magnetisable stent according to the invention. The designed biosorbability time-frame is achieved by adjusting the thickness of the stent accordingly.

[0059]Synthesis of magnetite: Iron acetylacetonate (Fe(acac)3) (0.396 g, 1.56 mmol), oleic acid (1.47 mL, 4.64 mmol), oleylamine (1.02 mL, 3.09 mmol), 1,2-hexadecanediol (2.005 g, 7.76 mmol) and benzyl ether (10 mL) were added to a single-neck round bottom flask equipped with a magnetic stir bar and a condenser and deoxygenated for an hour. The reaction was gradually heated at 3° C. / min to 200° C. and held at that temperature for 3 hours and then allowed to cool room temperatur...

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PUM

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Abstract

A biosorbable magnetisable endoprosthesis, may be useful in the therapy of restenosis. A method for the treatment of prevention of restenosis or a disease of thecoronary artery, comprises fitting a patent with an endoprosthesis according to the invention, which has either been magnetized prior to placement in the body or which is magnetized in situ, and administering to the patient magnetized cells capable of repairing an artery.

Description

FIELD OF THE INVENTION[0001]This invention relates to endoprostheses, in particular to coronary stents and to their use in the prevention and treatment of disease of the coronary arteries after angioplasty.BACKGROUND OF THE INVENTION[0002]Cardiovascular disease is the largest cause of death in the UK. This condition is characterised by a disease process called atherosclerosis, which is a thickening and hardening of the coronary arteries supplying blood to the heart. This often leads to chest pain (partial obstruction of blood flow) or a heart attack (a complete obstruction of blood flow, which is fatal in 50% of cases). Obstructive narrowing due to atherosclerosis can be relieved by ‘ballooning’ open the narrowing and inserting a stainless steel scaffold (coronary artery stent, which may also be used to stent other ‘tubes’ in the body) to prevent the narrowing from returning. This procedure, termed percutaneous angioplasty and stent insertion, is performed under local anaesthetic, a...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/02A61L31/00
CPCA61L31/148A61L31/022A61L31/005A61L31/088A61L31/18A61P7/02
Inventor MARTIN, JOHN FRANCISMATHUR, ANTHONY
Owner MAGNUS FLOW
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