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Plasma autoantibody biomarkers for basal like breast cancer

a breast cancer and autoantibody technology, applied in the field of breast cancer biomarkers, can solve the problems of low proliferation rate, low detection efficiency, and limited detection range of basal-like subtype cancers by current screening mammography

Inactive Publication Date: 2017-12-21
ARIZONA STATE UNIVERSITY +1
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text identifies 28 potential biomarkers for early detection of breast cancer. These biomarkers were selected from a study of 10,000 tumor antigens and have been validated in a blinded study. These biomarkers are useful for developing diagnostic tests and personalized therapies for breast cancer.

Problems solved by technology

Current screening mammography also has limitations in detecting the basal-like subtype cancers.
Early detection of BLBC by screening mammography is compromised partly by its high proliferation rate and lack of suspicious features of regular breast malignancy, such as microcalcifications, irregular spiculated masses or pleomorphic microcalcifications.
Moreover, BLBC is often present in women less than 50 years old, who are not recommended for routine mammogram by US Preventative Service Task Force mammogram guidelines.

Method used

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  • Plasma autoantibody biomarkers for basal like breast cancer
  • Plasma autoantibody biomarkers for basal like breast cancer

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Embodiment Construction

[0011]Notably, the sensitivity of a subtype-specific biomarker can never be higher than the prevalence of that subtype in the population where it is tested. The ability to find biomarkers for cancer detection with high sensitivities has likely been impaired by this effect. This is especially true for disease subtypes that are less common in the overall population. Basal like breast cancer is a breast cancer subtype with aggressive disease progression and poor prognosis. It overlaps significantly with triple negative breast cancer (TNBC), a clinical pathological subtype characterized by negative tissue staining of estrogen receptor (ER), progesterone receptor (PR), and the absence of human epidermal growth factor receptor 2 (HER2) amplification.

[0012]TNBC is associated with African American ethnicity, younger age, advanced stage at diagnosis and poorer outcomes. However, TNBC itself has been found to be molecularly heterogeneous in two recent studies. Among patients with TNBC, a core...

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Abstract

Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

Description

CROSS REFERENCE[0001]This application claims priority to U.S. provisional patent application 62 / 089,631 filed on Dec. 9, 2014, which is incorporated by reference herein in its entirety.STATEMENT OF GOVERNMENT RIGHTS[0002]This invention was made with government support under U01 CA117374 awarded by the National Institutes of Health. The government has certain rights in the invention.TECHNICAL FIELD[0003]The disclosure herein related to biomarkers for cancer and more particularly to autoantibody biomarkers for breast cancer.BACKGROUND[0004]Despite significant improvement in early detection by routine mammography, breast cancer remains a global challenge. Current screening mammography only detects 70% of breast cancers. Breast tumors associated with high breast density and highly proliferative cancers are frequently not detected by screening. Therefore, there is an urgent need for biomarkers that can detect potentially invasive breast cancer in their early stages.[0005]Like other cance...

Claims

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Application Information

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IPC IPC(8): G01N33/574C12Q1/68C07K16/30C12N15/11
CPCG01N33/57415C07K16/3015C12Q1/6886C12Q2600/112C12Q2600/158C12Q2600/118C12N15/11G01N33/564
Inventor LABAER, JOSHUAWANG, JIEQIU, JIWALLSTROM, GARRICKANDERSON, KARENPARK, JINFIGUEROA, JONINE
Owner ARIZONA STATE UNIVERSITY
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