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Apparatus

a technology of apparatus and coating particles, applied in the field of apparatus, can solve the problems of affecting the quality of coating particles,

Pending Publication Date: 2022-09-29
NANEXA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method of coating particles with a dense shell that fully encloses the solid core of the particles. This coating is achieved without any pinholes, breaks, or gaps through which the core could be exposed. The coated particles have the advantage of being more convenient, efficacious, potent, and having fewer side effects than similar treatments using the same active ingredient. The patent also highlights the unique pharmacological properties of the coated particles.

Problems solved by technology

The core of the coated particle being left exposed is particularly problematic where the core comprises a drug and the coating provides a means for a controlled release of that drug.
Burst release may be hazardous in the case of drugs that have a narrow therapeutic window.
Moreover, if the aggregates are not separated into particles of a desired size then the resultant coated particles have an uneven size distribution.
In particular, there would be large coated aggregates present which is highly undesirable when the particles are being used in a pharmaceutical composition.
Larger, aggregated particles will not only block the needle through which the suspension is to be injected, but also will not form a stable suspension because the large aggregates will not be properly suspended (they will instead tend to sink to the bottom of the injection liquid).

Method used

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Examples

Experimental program
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first embodiment

[0140]A reactor according to the invention is shown in FIG. 1a and is designated generally by reference numeral 10.

[0141]The reactor 10 includes a reactor vessel 12 which has first and second reactor chambers 14a, 14b. In the embodiment shown, the first and second reactor chambers 14a, 14b are positioned as “upper” and “lower” chambers relative to the reactor 10. However, it is appreciated that the orientation of the first and second reactor chambers 14a, 14b may mean that they cannot be designated with such relative terms.

[0142]The reactor 10 is able to receive particles, e.g. via an inlet (not shown) into the first (i.e. upper) reactor chamber 14a. As previously stated in the application, the particles are preferably nanoparticles or, more preferably, microparticles. In the examples given below, the particles are typically in powder form.

[0143]The reactor 10 also includes a sieve 16 which is located inside the reactor vessel 12 between the first and second reactor chambers 14a, 14...

second embodiment

[0183]A reactor according to the invention is shown in FIG. 2 and is designated generally by reference numeral 50.

[0184]The reactor 50 of the second embodiment of the invention is similar to the reactor 10 of the first embodiment of the invention, and like features share the same reference numerals.

[0185]The reactor 50 of the second embodiment differs from the reactor 10 of the first embodiment in that the forcing means 52 is integrated with the reactor vessel 12 such that the vessel 12 and sieve 16 act as a sonic sifter. In particular, the top of the first (upper) reactor chamber 14a and the bottom of the second (lower) reactor chamber 14b is fabricated from a polymeric material, preferably an elastomer, to form a polymer membrane 54. Moreover, the sieve 16 is also fabricated from a polymeric material, preferably an elastomer. Sound waves or ultrasonic sound waves are applied to the reactor vessel 12 via a generator (not shown) such that the whole vessel 12 acts as a sonic sifter w...

third embodiment

[0187]A reactor according to the invention is shown in FIGS. 3a and 3b and is designated generally by reference numeral 60.

[0188]The reactor 60 of the third embodiment of the invention is similar to the reactor 10 of the first embodiment of the invention, and like features share the same reference numerals.

[0189]The reactor 60 of the third embodiment differs from the reactor 10 of the first embodiment in that each of the first and second reactor chambers 14a, 14b has a sieving surface 62 which is made from a sieve mesh. The sieving surface 62 is located towards the bottom end of each first and second reactor chamber 14a, 14b.

[0190]Moreover, each of the first and second reactor chambers 14a, 14b has a shutter surface 64 both at the top and bottom surfaces of the chambers 14a, 14b, so that when the reactor chambers 14a, 14b are switched places with one another (as described in more detail below), there is always a shutter surface 64 of each chamber 14a, 14b located between the chambe...

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Abstract

A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS[0001]This patent application is a continuation of U.S. application Ser. No. 16 / 912,599, filed on Jun. 25, 2020, the entire contents of which, including the specification, drawings, claims and abstract, are hereby incorporated by reference in their entirety, for any and all purposes. U.S. application Ser. No. 16 / 912,599 claims the benefit of United Kingdom Priority application 1909314.5, filed Jun. 28, 2019, and United Kingdom Priority application 1917727.8, filed Dec. 4, 2019. United Kingdom Priority applications 1909314.5 and 1917727.8, the entire contents of which, including the specification, drawings, claims and abstract of each, are incorporated herein by reference in their entirety, for any and all purposes.BACKGROUND[0002]This invention relates to a reactor for forming fully coated particles having a solid core, a method of forming such fully coated particles and to a plurality of fully coated particles. The invention also relate...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C23C16/455A61J3/00B01J2/00B01J13/04B05B7/00C23C16/54C23C16/44B22F1/052B22F1/054B22F1/18
CPCC23C16/45544A61J3/005B01J2/006B01J13/04B05B7/0037C23C16/54C23C16/4412A61K9/501A61J3/00A61K9/5089B01J13/02C23C16/4417C23C16/442C23C16/45551C23C16/45555C23C16/458A61K9/143A61K9/5073A61K47/26B22F9/04B22F2009/043B22F2009/044C23C16/02C23C16/40C23C16/45502B22F1/054B22F1/052B22F1/18
Inventor JOHANSSON, ANDERSROOTH, MÅRTENHELLRUP, JOEL
Owner NANEXA