Sample carrier having sample tube blocking member

Abstract

A sample carrier comprising a lower support wall, a base joined to or in fixed proximity to a bottom end of the lower support wall, and sample tube receiving areas in fixed proximity to the lower support wall for receiving and holding a plurality of sample tubes in substantially vertical orientations. The sample carrier further comprising a blocking wall joined to a top end of the support wall which extends laterally over portions of sample tubes held by the sample carrier, thereby limiting vertical movement of the sample tubes during automated sampling procedures. The contents of sample tubes held by the sample carrier can be accessed by a robotic pipetting device. Additionally, a drip shield comprising a cover plate, a pair of through-holes for accessing sample tubes held by a the sample carrier, and a depending runner for maintaining the sample carrier on a sample carousel.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 60 / 381,551, filed May 17, 2002, and U.S. Provisional Application No. 60 / 443,458, filed Jan. 29, 2003, each of which applications is hereby incorporated by reference herein.FIELD OF THE INVENTION[0002]The present invention relates to a sample carrier for holding and containing a plurality of sample tubes. The sample carrier of the present invention is especially suited for use with an automated sampling system and sample tubes having penetrable caps. The present invention further relates to a drip shield for protecting against cross-contamination between sample tubes and for substantially limiting vertical movement of sample carriers positioned on conveying means during an automated sample transfer.INCORPORATION BY REFERENCE[0003]All references referred to herein are hereby incorporated by reference in their entirety. The incorporation of these references, standing alo...

AI Technical Summary

Benefits of technology

[0010]The openings of the transverse wall are preferably positioned so that at least a portion of the sample tube caps are contained within the openings between top and bottom surfaces of the transverse wall when the sample tubes are fully inserted into the sample tube holding means. Ideally, when portions of the caps are contained within the openings, the longitudinal axis of each cap should be no more than about 0.125 inches (3.18 mm) from the longitudinal axis of the corresponding opening and more preferably no more than about 0.1 inches (2.54 mm) from the longitudinal axis of the opening. Centering the caps prior to piercing them with a robotic pipetting device can aid in limiting the force required to penetrate the caps and, accordingly, can provide for more accurate pipetting.

[0022]The cover plate of the drip shield includes one or more through-holes, where each through-hole is configured and arranged to provide non-interfering, vertical passage of an aligned pipette tip therethrough. The through-holes are sized to permit access to the contents of only one sample tube at a time, where the sample tubes being accessed are present in a sample carrier positioned beneath the cover plate. In a preferred embodiment, the diameter of each through-hole is the same as or smaller than the smallest diameter of any sample tube held by the sample carrier to minimize opportunities for contaminating the sample carrier and its contents. A top surface of the cover plate may be chamfered or, alternatively, include a rim about the periphery of each through-hole. A chamfered through-hole could aid in redirecting a misaligned pipette tip through the through-hole, whereas a rimmed through-hole would provide a further barrier to fluid contamination of sample tubes. Because the sample carrier used in the preferred automated sampling system includes two sets of sample tube receiving areas on opposite sides of the lower support wall, the drip shield includes at least two through-holes in the cover plate which are configured and arranged to provide access to sample tubes on opposite sides of the support wall.

[0023]Depending from a bottom surface of the cover plate is at least one runner, an inner runner, which is configured and arranged to limit vertical movement of a sample carrier positioned beneath the drip shield. In the preferred embodiment, the drip shield further includes two outer runners depending from the bottom surface of the cover plate which are spaced-apart from the inner runner so that inner side walls of the outer runners and both side walls of the inner runner extend over sample tubes held by the sample carrier. This arrangement of runners will block vertical movement of a sample tube withdrawn from the sample tube holding means should the sample tube blocking member fail in its function.

Problems solved by technology

What these sample carriers lack, however, is a mechanism for ensuring that sample tubes remain in the sample carriers during automated sampling procedures when the retention force of a cap is greater than the holding force of the sample carrier on an associated vessel component.

As a consequence, there is a risk that penetrable caps which exert too great a retention force against fluid transfer devices will be withdrawn, along with their associated vessel components, from sample carriers during automated sampling procedures.

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