Influenza virus reassortment

a technology of influenza viruses and reassortments, applied in the field of influenza a virus reassortment, can solve the problems of segmentation of influenza viruses comprising a/pr not always growing well enough to ensure efficient vaccine manufacturing, and achieve the effect of fast growth

Active Publication Date: 2016-08-23
SEQIRUS UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0008]The inventors have now surprisingly discovered that influenza viruses which comprise backbone segments from two or more influenza donor strains can grow faster in a culture host compared with reassortant influenza A viruses which contain all backbone segments from the same donor strain. In particular, the inventors have found that influenza viruses which comprise backbone segments derived from two high-yield donor strains can produce higher yield reassortants with target vaccine-relevant HA / NA genes than reassortants made with either of the two original donor strains.

Problems solved by technology

However, reassortant influenza viruses comprising A / PR / 8 / 34 backbone segments do not always grow sufficiently well to ensure efficient vaccine manufacture.

Method used

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  • Influenza virus reassortment
  • Influenza virus reassortment
  • Influenza virus reassortment

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Embodiment Construction

[0008]The inventors have now surprisingly discovered that influenza viruses which comprise backbone segments from two or more influenza donor strains can grow faster in a culture host compared with reassortant influenza A viruses which contain all backbone segments from the same donor strain. In particular, the inventors have found that influenza viruses which comprise backbone segments derived from two high-yield donor strains can produce higher yield reassortants with target vaccine-relevant HA / NA genes than reassortants made with either of the two original donor strains.

[0009]In principle, all segments of closely related influenza A viruses can be specifically reassorted to produce viable viruses, but only a small fraction of these viruses will be high-growth reassortants, due to inefficient activities of the resulting viral components. The inventors have provided backbone combinations that produce the high yield strains. Reassortant influenza A viruses comprising backbone segmen...

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Abstract

New influenza donor strains for the production of reassortant influenza A viruses are provided.

Description

[0001]This patent application is a continuation of International Application No. PCT / EP2013 / 054227, filed Mar. 2, 2013, which claims priority from U.S. provisional patent applications 61 / 605,922, filed Mar. 2, 2012 and 61 / 685,766 filed Mar. 23, 2012, the complete contents of which are incorporated herein by reference.SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE[0002]The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: a computer readable form (CRF) of the Sequence Listing (file name: PAT055008_ST25.txt, date recorded: May 22, 2013, size: 161 KB).TECHNICAL FIELD[0003]This invention is in the field of influenza A virus reassortment. Furthermore, it relates to manufacturing vaccines for protecting against influenza A viruses.BACKGROUND ART[0004]The most efficient protection against influenza infection is vaccination against circulating strains and it is important to produce influenza viruses for vaccine production as quick...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K39/145C12N7/00
CPCC12N7/00C12N2760/16121C12N2760/16134A61P31/16A61K39/145A61K2039/525A61K2039/5252C07K14/005C12N2760/16122C12N2760/16151C12N2760/16161
Inventor SUPHAPHIPHAT, PIRADAMASON, PETERKEINER, BJOERNDORMITZER, PHILIPTRUSHEIM, HEIDI
Owner SEQIRUS UK LTD
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