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39 results about "OREXIN A RECEPTOR" patented technology

Small-molecule agonists for type-2 orexin receptor

Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Antianxiety drugs and a method of screening the same

InactiveUS20070160538A1Alleviate and eliminate anxietyNervous disorderPeptide/protein ingredientsAnti-Anxiety EffectOREXIN A RECEPTOR
An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.
Owner:EISIA R&D MANAGEMENT CO LTD

Small-molecule agonists for type-2 orexin receptor

Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Solid Dispersion Comprising An Orexin Receptor Antagonist

A solid dispersion comprising suvorexant or a salt thereof in amorphous form and at least one pharmaceutically acceptable matrix compound, wherein the matrix compound is (i) a polymer and wherein the solid dispersion contains the suvorexant or salt thereof in an 5 amount of at least 50 weight-% based on the combined weight of the suvorexant or salt thereof and the at least one matrix compound, or (ii) a silicon-based inorganic adsorbent.
Owner:SANDOZ AG

Octahydropyrrolo[3,4-c]pyrrole derivatives and use thereof

The invention relates to octahydropyrrolo[3,4-c]pyrrole derivatives and a use thereof. The above compounds and a medicinal composition containing the compounds are used for suppressing an orexin receptor. The invention also relates to a method for preparing the compounds and the medicinal composition, and the use of the compounds and the medicinal composition in the treatment or prevention of orexin receptor related diseases.
Owner:SUNSHINE LAKE PHARM CO LTD

Octahydropyrrolo[3,4-c]pyrrole derivative and application thereof

The invention relates to an octahydropyrrolo[3,4-c]pyrrole derivative and application thereof. The compound and a pharmaceutical composition containing the compound are used for antagonizing orexin receptors. The invention also relates to a method for preparing the compound and the pharmaceutical composition, and application of the compound and the pharmaceutical composition in treating or preventing diseases related to orexin receptors.
Owner:SUNSHINE LAKE PHARM CO LTD

Octahydropyrrolo[3,4-c]pyrrole derivative and application method and application thereof

The invention relates to an octahydropyrrolo[3,4-c]pyrrole derivative and an application method and application thereof. The compound and a pharmaceutical composition containing the compound are usedfor antagonizing orexin receptors. The invention also relates to a method for preparing the compound and the pharmaceutical composition and their application in treatment or prevention of diseases related to the orexin receptors.
Owner:SUNSHINE LAKE PHARM CO LTD

Crystal form of orexin receptor antagonist compound, and preparation method and application thereof

Disclosed are a preparation method of an orexin receptor antagonist compound 5-3, Crystalline forms I-IV of an orexin receptor antagonist compound 5-3 are provided. Also provided are processes of the preparing the orexin receptor antagonist compound 5-3 and its crystalline forms, as well as methods of using the crystalline forms I-IV for treating an orexin-related disease.
Owner:SHANGHAI HAIYAN PHARMA TECH +1

Substituted aryl heteroaryl compound and application thereof

The invention relates to a substituted aryl heteroaryl compound and application thereof, and further relates to a pharmaceutical composition containing the substituted aryl heteroaryl compound and application thereof. The compound or the pharmaceutical composition can be used for an antagonistic orexin receptor. The invention further relates to a method for preparing the compound and the pharmaceutical composition, and application of the compound and the pharmaceutical composition to preparation of drugs for treating or preventing nervous and psychogenic disorders and diseases of central nervous systems of mammals, especially human beings.
Owner:SUNSHINE LAKE PHARM CO LTD

Crystal form of octahydropyrrolo[3,4-c]pyrrole derivative

The invention relates to a crystal form of an octahydropyrrolo[3,4-c]pyrrole derivative. The invention also relates to a pharmaceutical composition containing the crystal form, and an application of the crystal form or the pharmaceutical composition in preparation of medicines for preventing, treating or relieving diseases related to orexin receptors.
Owner:SUNSHINE LAKE PHARM CO LTD

Octahydropyrrolo[3,4-c]pyrrole derivatives and methods and uses thereof

The invention relates to an ctahydropyrrole[3, 4-c]pyrrole derivative and a using method and application thereof. A compound and a drug composition containing the same are used for resisting orexin receptors. The invention further relates to methods of preparing the compound and the drug composition and application of the compound and the drug composition in treating or preventing diseases related to the orexin receptors.
Owner:SUNSHINE LAKE PHARM CO LTD

Piperidine derivatives as orexin receptor antagonists

The invention discloses a series of piperidine derivatives as orexin receptor antagonists and their compositions, and relates to their use in the preparation and treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, drowsiness, anxiety, compulsion, panic, Drug use in nicotine dependence or disordered eating disorders.
Owner:SHANGHAI HAIYAN PHARMA TECH +2

Proline sulfonamide derivatives as orexin receptor antagonists

The present invention relates to (S)-proline sulfonamide compounds of formula (I), wherein R1 and R2 are as described in the description, or pharmaceutically acceptable salts thereof, for use in the prevention or treatment of diseases or disorders related to the orexin system. The present invention also relates to the use of (S)-proline sulfonamide compounds of formula (II) as pharmaceuticals, to pharmaceutical compositions comprising compounds of formula (II), and especially their use in the prevention or treatment of diseases or disorders related to the orexin system.
Owner:IDORSIA PHARM LTD

Crystal forms of octahydropyrrolo[3,4-c]pyrrole derivatives

The present invention relates to crystal forms of octahydropyrrolo[3,4-c]pyrrole derivatives. The present invention also relates to a pharmaceutical composition comprising the crystalline form, and the use of the crystalline form or the pharmaceutical composition in the manufacture of a medicament for preventing, treating or alleviating orexin receptor-related diseases.
Owner:SUNSHINE LAKE PHARM CO LTD

Human monoclonal antibodies against orexin receptor type 1

The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +3
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