Benzimidazole Proline Derivatives

A benzimidazole and phenyl technology, applied in the field of benzimidazole proline derivatives, can solve problems such as no effective therapy yet
CN104334544BActive Publication Date: 2016-10-19IDORSIA PHARM LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
IDORSIA PHARM LTD
Publication Date
2016-10-19

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Abstract

The present invention relates to the compound of formula (I), wherein Ar1, R1, R2, R3, R4a, R4b and (R5)n are as described in the description; its preparation, its pharmaceutically acceptable salt and its use as medicine Uses, pharmaceutical compositions containing one or more compounds of formula (I), and especially with respect to their use as orexin receptor antagonists.
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Description

technical field

[0001] The present invention relates to novel benzimidazole proline derivatives of formula (I) and their use as medicines. The present invention also relates to methods for the preparation of these compounds, pharmaceutical compositions containing one or more compounds of formula (I) and their use as orexin receptor antagonists, especially as orexin-1 receptor antagonists. appearance. Background technique

[0002] Orexin (orexin A or OX-A and orexin B or OX-B) is a neuropeptide discovered by two research groups in 1998, orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T et al., Cell, 1998, 92, 573-585). Orexin is produced in discrete neurons of the lateral hypothalamus and binds to G-protein-coupled receptors (OX 1 and OX 2 receptor) binding. Orexin-1 receptor (OX 1 ) is selective for OX-A, and the orexin-2 receptor (OX 2 ) can bind OX-A as well as OX-B. Orexin receptor antagonists are a novel class of neurological ...

Claims

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