98 results about "Pyrrole derivatives" patented technology

The invention relates to a pyrimidopyrrole derivative and application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a co-crystal of the compound, an intermediate and a preparation method of the compound, and application of the compound in BTK related diseases such as tumors or autoimmune system diseases. # imgabs0 #

The invention discloses a high-safety electrolyte and a lithium ion battery, and belongs to the technical field of lithium ion batteries. According to the high-safety electrolyte provided by the invention, a small amount of an anti-overcharge additive 2-phenyl-pyrrole derivative is added into the electrolyte, the compound is subjected to polymerization reaction when the voltage exceeds 4.1 V, and then a compact insulating polymer layer is generated on the surface of a positive electrode, so that a positive electrode active material is prevented from being in contact with the electrolyte, and the overcharge resistance of the positive electrode is improved. And a lithium ion migration path in the battery is cut off, so that the risk of overcharge thermal runaway of the battery is reduced. And after the 2-phenyl-pyrrole derivative is added into the electrolyte, certain water removal and acid inhibition effects are achieved, the 2-phenyl-pyrrole derivative does not participate in negative electrode film formation, and the cycle life and the power performance of the lithium ion battery are not influenced.

The present invention relates to a process for the preparation of diketones and pyrrole derivatives, optionally substituted in the 2 and / or 5 positions, from furans.

The invention relates to a tetraarylmethane compound with indole and pyrrole frameworks and a synthesis method thereof. The chemical structural formula of the compound is shown as a formula 3. The synthesis method comprises the following steps: adding 2-indolyl carbinol and a pyrrole derivative as reaction raw materials into an organic solvent, stirring and reacting at room temperature under the catalysis of Bronsted acid or Lewis acid in the presence of an additive # imgabs0 # molecular sieve, tracking the reaction by TLC until the reaction is complete, filtering, concentrating and purifying to obtain the 2-indolyl carbinol derivative. According to the tetraarylmethane compound with indole and pyrrole frameworks synthesized by the invention, a biological activity test shows that the derivative has relatively high sensitivity and very strong cytotoxic activity on human liver cancer cells HepG2. According to the method, reaction conditions are relatively conventional, the reaction process is mild, simple and convenient, the cost is low, the method is suitable for industrial large-scale production, and the application range of the method is widened; various substrates are used as reactants, products with various structures are obtained, and the yield is high. # imgabs1 #

The invention discloses a tetrahydropyrrole derivative and a synthesis method thereof. The synthetic method comprises the following steps: in the presence of a heterogeneous supported bimetallic catalyst and an organic solvent, mixing and reacting amines and dihydric alcohols to prepare the tetrahydropyrrole derivative. According to the method disclosed by the invention, not only is the use of an alkaline additive avoided and the use requirement of equipment reduced, but also the high yield and high purity of the finally prepared tetrahydropyrrole derivative are ensured.

The present invention relates generally to elastomeric compositions comprising at least one sp2-hybridized carbon allotrope and a 2, 5-disubstituted pyrrole derivative, preferably provided in the form of a preformed adduct, processes for their preparation and tires comprising such elastomeric compositions. The invention also relates to adducts between said pyrrole derivatives and sp2 hybrid carbon allotropes and to processes for their preparation.

The invention discloses an azacyclo-derived polyaryl methane anti-tumor compound and a synthesis method thereof. The chemical structural formula of the compound is shown as a formula 3. The synthesis method comprises the following steps: adding 2-pyrrole derivative indole and aromatic aldehyde as reaction raw materials into toluene, stirring and reacting for 6-10 hours at 25 DEG C under the catalysis of binaphthyl phosphoric acid, tracking the reaction by TLC until the reaction is complete, filtering, concentrating and purifying to obtain the 2-pyrrole derivative indole. According to the azacyclo-derived polyaryl methane compound synthesized by the invention, a biological activity test shows that the derivative has relatively high sensitivity and very strong cytotoxic activity on human breast cancer cells MCF-7. The method is conventional in reaction condition, mild and simple in reaction process, low in cost and suitable for industrial large-scale production, and the application range of the method is widened; according to the method, various substrates are used as reactants, and products with various structures are obtained. # imgabs0 #

The invention provides an anti-ultraviolet aging additive and application thereof. The additive is a pyrrole derivative which is connected to boron nitride and contains an amino group and an ester group at the same time, and an additional five-membered ring or six-membered ring can be formed in an intramolecular hydrogen bond form. A five-membered ring containing an amino group and an ester group is connected to boron nitride, so that a hydrogen bond can be formed in a molecule to construct another five-membered ring or six-membered ring, and the energy of ultraviolet light is absorbed by utilizing the damage of the five-membered ring or six-membered ring formed by the hydrogen bond; meanwhile, the boron nitride can lead out heat brought by sunlight as soon as possible, and the phenomenon of hydrogen bond breakage caused by heat accumulation is avoided. According to the scheme, the ultraviolet resistance of the ABS is improved, so that the ABS has more excellent ageing resistance.

The present disclosure relates to a novel salt of a 1-sulfonyl pyrrole derivative, and to a novel salt having excellent solubility in vivo, stability, bioavailability, and the like, a preparation method thereof, and a pharmaceutical composition comprising the same.

The present invention relates to a novel pyrrole derivative compound or a pharmaceutically acceptable salt thereof. In addition, the present invention relates to a pharmaceutical composition for potassium-competitive inhibition of gastric acid secretion and a pharmaceutical composition for preventing or treating diseases caused by gastric acid secretion disorder, the pharmaceutical composition containing the novel pyrrole derivative compound or a pharmaceutically acceptable salt thereof as an active component. The pyrrole derivative compound or the like according to the present invention is a potassium-competitive acid blocker (PCAB) and has an excellent H+ / K+ adenosine triphosphatase (ATPase) (proton pump) inhibition effect, and is thus widely used as a therapeutic agent for diseases caused by gastric acid secretion disorder.

The present invention relates to sp 2 The invention further relates to a tyre for vehicle wheels comprising at least one structural element comprising a crosslinked elastomeric material obtained by crosslinking such a crosslinkable elastomeric composition.

The invention discloses an axially chiral aryl pyrrole derivative, a preparation method thereof and application of the axially chiral aryl pyrrole derivative as a chiral catalyst, and relates to the technical field of organic matter synthesis. According to the invention, substituted primary amine and enyne are taken as raw materials and react in the presence or absence of an additive in the presence of a copper salt and a PyBOX ligand to obtain a novel axially chiral aryl pyrrole derivative, and a method for forming an aryl pyrrole rotation-hindered isomer through [1 + 4] cyclization of the primary amine and electron-deficient enyne under the catalysis of metal is developed. According to the present invention, the used catalyst is easily available, the preparation cost is low, the synthesis method is suitable for a variety of substrates, a variety of axially chiral aryl pyrrole compounds with novel structures can be constructed, and the obtained aryl pyrrole compound has characteristics of high yield and excellent enantioselectivity. The synthesis route of the aryl pyrrole compound is expanded, and a foundation is laid for further exploration and application of the compounds in asymmetric catalysis, drug development and other chemical fields.

The invention relates to the technical field of medicines, and discloses an atrasentan derivative as well as a preparation method and application thereof. The atrasentan derivative is a tetra-substituted pyrrole derivative designed by taking atrasentan as a pilot, and the synthesis difficulty and cost are remarkably reduced by reducing three chiral centers; the atrasentan derivative has relatively high safety to HK-2 cells, and the pathological state of fibrosis generated by TGF-beta induced HK-2 can be remarkably improved; the application has the potential of being applied to preparation of drugs for preventing and treating renal fibrosis related diseases, the synthesis bottleneck of atrasentan is broken through, and a brand new candidate drug is provided for renal fibrosis treatment.

The invention provides a composite electrolyte, a positive pole piece and an all-solid-state battery, the composite electrolyte comprises a sulfide electrolyte and a functional additive, the functional additive is selected from at least one of a benzofuran derivative, a thiophene derivative and a pyrrole derivative, based on the total mass of the composite electrolyte, the mass fraction of the functional additive is 0.1-5%, and the mass fraction of the sulfide electrolyte is 0.1-5%. When the battery is charged for the first time, the functional additive in the positive electrode is subjected to in-situ reaction under a specific potential, and a compact and stable interface layer with high ionic conductivity is generated on the surface of the positive electrode active material particles, so that the problem of interface side reaction can be solved, and the service life of the battery is prolonged. And the cycle performance and the first-circle discharge capacity of the battery are improved.

The invention discloses an organic phosphorescent material based on a dithipyrrole derivative modified by a carbazole derivative as well as a preparation method and application of the organic phosphorescent material, belongs to the technical field of luminescent materials, and overcomes the defects that the existing pure organic phosphorescent material is low in luminous efficiency, short in service life and high in environmental sensitivity through molecular structure design. Meanwhile, the problems of toxicity and biological incompatibility of heavy metal materials are avoided. By introducing carbazole and derivative groups thereof, the optical performance and application value of the material are remarkably improved, and the material has a wide application prospect in the fields of biological imaging and phototherapy. Therefore, the method has important innovative significance and practical value in the fields of organic photoelectric materials and biomedical materials.

The invention provides a compound shown in a general formula I or pharmaceutically acceptable salt, stereoisomer, tautomer, a composition containing the compound, a preparation method, an intermediate and application in the field of medicine. # imgabs0 #

A tetraarylmethane compound possessing both indole and pyrrole skeletons and its synthetic method are disclosed. The chemical structural formula of the compound is shown in Formula 3. The synthetic method involves adding 2-indole-methanol and a pyrrole derivative as reactants to an organic solvent. Under the catalysis of Brønsted acid or Lewis acid and in the presence of molecular sieve additives, the reaction is stirred at room temperature. The reaction is monitored by TLC until complete, followed by filtration, concentration, and purification to obtain the final product. The tetraarylmethane compound possessing both indole and pyrrole skeletons synthesized in this invention exhibits high sensitivity and strong cytotoxic activity against HepG2 human liver cancer cells through bioactivity testing. The reaction conditions of this invention are relatively conventional, the reaction process is mild, simple, and low-cost, suitable for large-scale industrial production, thus broadening the applicability of this method. A variety of substrates are used as reactants, resulting in structurally diverse products with high yields.

The invention discloses a nitrogen-embedded indanone C60 derivative with an addressable spinning energy level and a preparation method of the nitrogen-embedded indanone C60 derivative. A double-cavity structure with an ion source cavity and a reaction cavity connected in series is adopted for preparation, and the preparation method comprises the following steps: taking the indanone C60 derivative as a sublimation raw material, and bombarding the sublimated indanone C60 derivative by using a nitrogen-containing ion beam to realize ion implantation so as to directly form the nitrogen-embedded indanone C60 derivative. Through modification of indanone and introduction of zero field splitting, electron spin transition of embedded nitrogen atoms is degenerated, good spin energy level addressability is achieved, and zero field splitting parameters are respectively calibrated as D = 17.17 MHz and E = 0.39 MHz. The preparation method overcomes the double difficulties of difficult synthesis of the intrinsic nitrogen-embedded fullerene in the preparation of the nitrogen-embedded fullerene derivative and ineffective loss of the intrinsic nitrogen-embedded fullerene in the chemical modification process.

The present invention relates to a pyrrole derivative or a pharmaceutically or sitologically acceptable salt thereof, and composition for prevention, amelioration or treatment of gastrointestinal disorders comprising same as active ingredient. Through the results, it can be confirmed that the pharmacokinetic parameters, oral bioavailability and storage stability of the compound of the present invention are remarkably improved due to deuteration of the terminal methylamine moiety. The pyrrole derivative or the pharmaceutically or sitologically acceptable salt thereof the present invention exhibits excellent anticancer activity in addition to excellent proton pump inhibitory activity, and has improved pharmacokinetic parameters and chemical stability, and thus can be effectively used in the prevention, amelioration or treatment of gastrointestinal disorders, including gastric cancer.

This invention relates to the field of pharmaceutical technology, and discloses an atrasentan derivative, its preparation method, and its applications. The atrasentan derivative is a tetrasubstituted pyrrole derivative designed using atrasentan as a lead, significantly reducing the difficulty and cost of synthesis by decreasing three chiral centers. This atrasentan derivative exhibits high safety in HK-2 cells and can significantly improve the pathological state of fibrosis induced by TGF-β in HK-2 cells. It has the potential to be used in the preparation of drugs for the prevention and treatment of renal fibrosis-related diseases, breaking through the synthetic bottleneck of atrasentan and providing a novel candidate drug for the treatment of renal fibrosis.

The invention discloses a near-infrared two-region imaging material and a preparation method and application thereof, and belongs to the technical field of photoelectric functional materials. The near-infrared two-region imaging material is an aza-fluorine boron pyrrole derivative NJ1040; the preparation method comprises the following steps: dissolving 2-acetylthiophene in ethanol to obtain a mixed solution, adding a potassium hydroxide aqueous solution, stirring, adding 4-diethylaminobenzaldehyde, stirring, and extracting; drying the extracted organic phase, and performing rotary evaporation concentration and purification to obtain an intermediate I; mixing the intermediate I, diethylamine and nitromethane, reacting, extracting, drying the extracted organic phase, and performing rotary evaporation concentration and purification to obtain an intermediate II; mixing the intermediate II, ammonium acetate and ethanol for reaction, adding triethylamine and a boron trifluoride diethyl etherate complex for continuous reaction after rotary evaporation concentration, and extracting; and drying the extracted organic phase, carrying out rotary evaporation concentration, and purifying to obtain the product. NJ1040 nanoparticles are prepared by a nano coating technology, so that the problem of poor solubility of a contrast agent is solved.

The present invention relates to adducts between sp2 hybridized carbon allotropes and pyrrole derivatives comprising at least one sulphur atom, and crosslinkable elastomer compositions comprising such adducts. The present invention further relates to tyres for vehicle wheels comprising at least one structural element comprising a crosslinked elastomer material obtained by crosslinking of such crosslinkable elastomer compositions.

The invention provides a disubstituted tetrahydropyrrole derivative as well as a preparation method and application thereof. Specifically, provided are a compound represented by formula I, a stereoisomer, an ester or a pharmaceutically acceptable salt thereof, and a use thereof in preparation of drugs for preventing or treating epinephrine beta3 receptor related diseases.

The invention discloses a photopolymerization composition of a series of aza-boron-fluorine dipyrrole derivatives, and belongs to the technical field of photocuring materials. In the composition, the aza-boron-fluorine dipyrrole derivative is used as a photosensitizer, has high molar extinction coefficient, excellent light stability and wide spectral response characteristic, and can realize efficient intersystem crossing and long triplet service life. After being compounded with tris (3-chloro-4-methylphenyl) hexyl tetrabutylammonium borate (NB), the acrylate monomer polymerization can be rapidly initiated under 365 nm ultraviolet light, the curing time is within 20 seconds, and the highest double bond conversion rate can reach 75%. Wherein the brominated aza-BODIPY derivative (ADP-Br) can also be efficiently polymerized under the irradiation of 620 nm red light, and the conversion rate of double bonds can be up to 50%. The photopolymerization system disclosed by the invention is high in initiation efficiency, high in curing speed and wide in application scene, and can be applied to the fields of photocureable coatings, adhesives, photoetching materials, 3D printing and the like.

The invention provides a pyrrole derivative, belongs to the technical field of organic electroluminescence, and also relates to an application of the compound in an organic electroluminescence device. The pyrrole derivative is characterized in that the compound has a structure as shown in a formula (1): # imgabs0 #, and an organic electroluminescent device containing the pyrrole derivative can effectively improve the balance of holes and electrons in a luminescent layer and improve the current efficiency of the device.

The invention discloses a diketopiperazine tetrahydropyrrole derivative as well as a preparation method and application thereof, and belongs to the technical field of medicines. The technical problem to be solved is to provide the diketopiperazine tetrahydropyrrole derivative with a new structure and the preparation method thereof. The key points of the technical scheme are as follows: the diketopiperazine tetrahydropyrrole derivative is a compound as shown in the following formula I, an isomer, a prodrug, a stable isotope derivative, a pharmaceutically acceptable salt or a mixture of the compounds, the isomer, the prodrug, the stable isotope derivative and the pharmaceutically acceptable salt, wherein L1 and L2 are independently selected from substituted or unsubstituted alkylene; x1 and X2 are respectively and independently selected from N, O or S; and L3 is independently selected from substituted or unsubstituted heterocyclic alkyl. Formula I

The invention provides an application of a sulfonyl pyrrole derivative in preparation of a medicine for treating sepsis. The medicine can effectively block the formation of sepsis thrombosis by inhibiting the activity of FXIIa.

One embodiment of the present invention provides a semiconductor photoresist composition with excellent resolution characteristics and pattern adhesion by reducing the influence of variables during pattern formation and improving CD (critical dimension) stability. [Solution] The present invention relates to a semiconductor photoresist composition comprising an organometallic compound; a pyrrole-based compound including pyrrole, a pyrrole derivative, or a combination thereof; and a solvent, and a pattern formation method utilizing the same.

A pyridopyrrole derivative and the use thereof in medicine. In particular, the present invention relates to a compound as represented by general formula (I0) or general formula (I0-1), or a stereoisomer, racemate, deuterated substance, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, and an intermediate thereof, a preparation method therefor, and the use thereof in the preparation of a drug for treating diseases associated with the FGFR2 activity or expression level.

This invention discloses a method using arylmethyl ketones and 2-aryl- N This invention relates to a method for synthesizing dihydropyrrole derivatives using toluenesulfonylaziridine as a starting material, belonging to the field of organic synthetic chemistry. The method uses tris(dibenzylacetone)dipalladium (Pd2(dba)3) as a catalyst, and 2-iodobenzoic acid (IBX) and potassium persulfate (K2S2O8) as co-oxidants. N,N Using dimethylformamide (DMF) as both solvent and carbon source, the reaction is carried out in an oil bath at 100℃–120℃ for 15–24 h, followed by post-treatment to obtain dihydropyrrole derivatives. This invention utilizes readily available raw materials, is simple to operate, employs mild reaction conditions, exhibits broad functional group compatibility, provides high product selectivity, and is environmentally friendly. Yields can reach 51%–90%, making it suitable for large-scale preparation of structurally diverse dihydropyrrole derivatives. It has significant application value in drug development, natural product synthesis, and materials chemistry.