Artificial kidney having function of metabolizing profein and method of constituting same

A technology of metabolic function and artificial kidney, applied in drug combination, prosthesis, tissue regeneration, etc., can solve problems such as insurmountable shortcomings

Inactive Publication Date: 2007-09-05
KANEKA CORP +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these are extracorporeal devices and thus cannot overcome the disadvantages of intermittent blood therapy

Method used

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  • Artificial kidney having function of metabolizing profein and method of constituting same
  • Artificial kidney having function of metabolizing profein and method of constituting same
  • Artificial kidney having function of metabolizing profein and method of constituting same

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Embodiment Construction

[0020] The in vivo artificial kidney having the function of metabolizing protein of the present invention comprises, as a component, a sponge sheet having a hydrogel containing injected pro-angiogenic growth factors and cells expressing megalin on the surface.

[0021] As the pro-angiogenic growth factor used in the present invention, there can also be basic fibroblast growth factor (bFGF), acidic fibroblast growth factor (aFGF), epidermal growth factor (EGF), transforming growth factor-alpha (TGF -α), vascular epithelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), and hepatocyte growth factor (HGF).

[0022] In the present invention, the above-mentioned pro-angiogenic growth factors may comprise one or more combinations. In addition, another biologically active factor may also be incorporated.

[0023] For stronger growth activity, bFGF and PDGF-BB are preferred. Furthermore, bFGF, being a widely recognized pro-angiogenic growth factor, is most prefer...

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Abstract

The present invention provides an intra-corporeal artificial kidney having a function of metabolizing protein and a method of constructing the same. The present invention provides an intra-corporeal artificial kidney having a function of metabolizing protein which comprises, as constituent elements, a sponge sheet with an angiogenesis promoting growth factor-containing hydrogel injected therein as well as cells with megalin, which is an endocytosis receptor playing a central role in the protein metabolizing function of proximal tubular cells, as expressed on the surface of the cells, and a method of constructing an intra-corporeal artificial kidney having the function of metabolizing protein which comprises using a sponge sheet with an angiogenesis promoting growth factor-containing hydrogel injected therein as well as cells with megalin expressed on the surface.

Description

technical field [0001] The present invention relates to an in vivo artificial kidney with protein metabolism function, which comprises a sponge sheet as a component, which is injected into a hydrogel containing growth factors promoting angiogenesis, and cells expressing megalin on the surface, and its construction method. Background technique [0002] In Japan, hemodialysis is the main treatment for end-stage renal insufficiency due to the lack of donors for kidney transplantation. Hemodialysis, however, does not fully compensate for the original renal function, as various induced complications impair quality of life (QOL) and important patient outcomes. [0003] Hemodialysis is deficient in that it cannot compensate for the metabolic function of tubular filtered proteins possessed by proximal tubular cells. Therefore, the low-molecular-weight protein originally metabolized by these cells accumulates in the patient's body, becomes uremic toxin protein, and causes various di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02A61L27/38A61K45/00A61P1/16A61L27/52C12N5/08
CPCA61L2430/26A61L27/3813A61L27/3839A61F2/02A61L27/52A61P1/16A61M1/14
Inventor 田畑泰彦斋藤亮彦下条文武古吉重雄山下宪司
Owner KANEKA CORP
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