New combination of Cefpirome Sulfate and preparation method

A technology of cefpirome sulfate and its composition, which is applied in the field of new composition of cefpirome sulfate and its preparation, and can solve problems such as no benefit to the human body

Inactive Publication Date: 2007-12-26
NANJING CHENXIANG MEDICAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using a double-chamber bag, there will undoubtedly be a certain amount of carbon dioxide entering the human body. Although it is not certain how harmful the carbon dioxide entering the body is, it is definitely not beneficial to the human body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] For the preparation method of cefpirome sulfate sterile mixed powder for injection:

[0022] Under the environment of aseptic cleanness and air relative humidity not greater than 55%, mix cefpirome sulfate and L-arginine aseptic powder, grind them, and pass through a No. 6 sieve to obtain the mixed powder. The composition of the prescription is shown in Table 3

[0023] Table 3 Cefpirome Sulfate Feeding Amount and Feeding Ratio

[0024] Element

Embodiment 2

[0026] For the preparation method of cefpirome sulfate sterile mixed powder for injection:

[0027] Under the environment of aseptic cleanness and air relative humidity not more than 55%, mix cefpirome sulfate and L-lysine aseptic powder, grind them, and pass through a No. 6 sieve to obtain the mixed powder. The composition of the prescription is shown in Table 4

[0028] Table 4 Cefpirome Sulfate Feeding Amount and Feeding Ratio

[0029] Element

Embodiment 3

[0031] Preparation of Cefpirome Sulfate Sterile Powder for Injection

[0032] Take by weighing the cefpirome sulfate sterile mixed powder for injection (prescription composition sees Table 5) that obtains by embodiment 1 method, under the environment that aseptic cleaning and air relative humidity are not more than 55%, fill in the 10ml vial , wipe, full inspection, printing, packaging.

[0033] The prescription composition (1000 bottles) of cefpirome sulfate sterile powder for injection of table 5

[0034] Element

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PUM

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Abstract

A cefpirome sulfate as a newm edicine and its preparing process which features use of alkaline or neutral amino acid as cosolvent are disclosed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a new composition of cefpirome sulfate and a preparation method thereof. Background technique [0002] Cefpirome sulfate is the fourth-generation cephalosporin antibiotic. Compared with the first, second and third-generation cephalosporins, the fourth-generation cephalosporin has a wider antibacterial spectrum, is more stable to β-lactamase, has a higher blood concentration, Can pass through the blood-brain barrier. It has been clinically confirmed that it has a good curative effect on superficial secondary infections such as sepsis, trauma, and surgical trauma. Cefpirome has good bactericidal activity against bacterial meningitis pathogens and good penetration of the blood-brain barrier, so this product has achieved good curative effect in the treatment of meningitis infection. Although the half-life of cefpirome is short (about 2 hours), the concentration of the dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61P31/04
Inventor 邢为藩
Owner NANJING CHENXIANG MEDICAL RES
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